Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites

Susceptibility of Gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology

“…We recently described the methods for the synthesis of NO-np. 10 Briefly, a composite hydrogel/glass particle was generated from tetramethylorthosilicate (TMOS), polyethylene glycol (PEG), chitosan, glucose and sodium nitrite in 0.5 M sodium phosphate buffer (pH 7). NO was produced by reduction of the nitrite within the matrix.…”

“…-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology recently developed an inexpensive, stable and rapidly deployable NO-releasing platform using silane hydrogel-based nanotechnology. 10 The sustained release rate and total concentration of NO can be modulated by altering the methods for nanoparticle production, for example, by changing the molecular weight of polyethylene glycol or the concentration of nitrite encapsulated. Moreover, our platform benefits from the presence of chitosan, which has been shown to have a potent antimicrobial activity against bacteria.…”

Nitric oxide releasing-dendrimers: an overview

“…A reasonable volume of the current research have been focused on attaching NO releasing compounds to different platforms (Eroy-Reveles, Mascharak, 2010;Tfouni et al, 2010;Seabra, Durán, 2010;Riccio, Schoenfisch, 2012;Jen et al, 2012), as nanoparticles (Friedman et al, 2008;Seabra, Durán, 2010), silica gel (Zanichelli, Sernaglia, Franco, 2006;Doro, Rodrigues-Filho, Tfouni, 2007), xerogels and dendrimers (Stasko, Schoenfisch, 2006;Stasko, Fischer, Schoenfisch, 2008;Benini, McGarvey, Franco, 2008;Lu et al, 2011). These strategies aimed to improve NO-donors stability (Lu et al, 2011), promote a high payload of nitric oxide on a single platform (Stasko, Schoenfisch, 2006;Stasko, Fischer, Schoenfisch, 2008) and achieve specific targets (Taite, West, 2006).…”

Nanoparticles as a Novel Delivery Vehicle for Therapeutics Targeting Erectile Dysfunction

“…Recently, hybrid hydrogel/glass nanoparticles were developed that could potentially facilitate transcutaneous transport of biologically active substances ranging from nitric oxide (NO) to small peptides and possibly to larger macromolecular entities and assemblies [3]. It is well established that these types of nanoparticles provide excellent matrices for encapsulating a wide variety of organic and inorganic compounds, including many biologically relevant materials, such as proteins [4][5][6], NO [3], and pharmaceuticals [7].…”

“…It is well established that these types of nanoparticles provide excellent matrices for encapsulating a wide variety of organic and inorganic compounds, including many biologically relevant materials, such as proteins [4][5][6], NO [3], and pharmaceuticals [7]. The resulting material can be converted into powders comprised of nanoparticles with average diameters in the range of tens of nanometers (for comparison, viruses are 10-300 nm or eukaryotic cells 2-100 μm in diameter).…”