Sustained Release of Antimicrobial Drugs from Polyvinylalcohol and Gum Arabica Blend Matrix

Abstract

Synthetic polymers are widely used in biomedical applications. Polymer blends have recently paved their way in this field. An attempt to prepare blend of synthetic polymer polyvinylalcohol and natural macromolecule gum arabica is made in this paper. Characterization of these blends by NMR, DSC and viscoelastic studies reveal preparation of a blend composition with synergistic properties. The blend composition with synergistic properties was used to release various antimicrobial drugs. The duration and release of the drug depends on the amount of drug loaded in the matrix and solubility of the drug in the matrix and release medium. The advantage of this system is that the release kinetics of the drug from the system can be tailored by adjusting plasticizer, homopolymer and crosslinker composition depending on the drug to be released.

Drug delivery systems: An updated review

“…In albino rats, the various factors affecting systemic absorption of nasally applied gentamycin sulphate using in situ nasal perfusion technique was studied. [ 37 ] Tween 80 which is a surfactant increases permeation by altering membrane structure and permeability. In this study Tween 80 upto 1% w/v concentrations, increased permeability.…”

Characterization, Thermal, and Mechanical Behaviours of Gamma Irradiated Gum Arabic/Poly Vinyl Alcohol Polymer Blends

“…The polymer solutions were then mixed with different ratios ranging from 10=90 to 30=70 wt. % (GA=PVA), which is the range of compatibility of the components of the blend as reported in the literature [14] and cross-linking agent was added to the blend solution. The complete miscible solution was then casted onto glass dishes to obtain transparent films with definite thickness that were dried in a vacuum oven at 50 C. The prepared films were exposed to gamma irradiation at the required doses (20, 30, and 50 kGy) at a dose rate of 4 kGy h À1 at the cobalt À60, gamma source under atmospheric conditions.…”

“…Also, it has good film forming and high hydrophilic properties. Many research works have dealt with polymer blends of PVA such as PVA=poly(carboxymethyl cellulose) [8] , PVA=lactose blend [9] , PVA=starch blend and PVA=GA blend for release of antimicrobial drugs [10] .…”

Intramolecular and intermolecular crosslinked poly(vinyl alcohol)–borate complexes for the sustained release of fertilizers and enzymes

“…Poly(vinyl alcohol) (PVA) is well known to be a polymer that can crosslink with boron as the linking agent, with its biocompatibility and biodegradable properties,19 which are useful in various applications. For example, Orienti et al20 synthesized hydrogels using PVA for sustained drug‐delivery release while it was mixed with Arabic gum to yield a similar system to release antimicrobial drugs 21…”