Sustained uterine contractions: a cause of hypointense myometrial bulging.

Togashi, Kaori; Kawakami, Satoshi; Kimura, I; Asato, Reinin; Takakura, Kenji; Mori, Takahide; Konishi, Junji

doi:10.1148/radiology.187.3.8497617

Cited by 56 publications

(51 citation statements)

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“…Sustained uterine contractions were defined as areas of distinct low-signal intensity that bulged into the endometrial cavity and were sustained throughout a cine mode display of 60 serial images [17,18]. Image analysis of a sustained contraction for both groups was independently visually performed by two board-certified radiologists (A.K., K.T.).…”

Section: Image Analysis Of Uterine Peristalsismentioning

confidence: 99%

Cine MR imaging of uterine peristalsis in patients with endometriosis

Kido

Togashi

Nishino³

et al. 2006

Eur Radiol

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Endometriosis is one of the most important causes of infertility; however the precise mechanism by which it affects female fertility is unclear. The objective of this study was to study the functional aspects of the uterus by evaluating uterine contractility in patients with endometrial cysts of the ovary. The study population was recruited from two institutes and consisted of 26 women (periovulatory (10), luteal (13), and menstrual phase (3); age range: 19-51 years) with untreated endometriosis; the control group consisted of 12 healthy women (age range: 22-41 years). Cine MR imaging obtained by a 1.5T magnet was visually evaluated at 12x faster than real speed, focusing on the presence of uterine peristalsis, the direction and frequency of peristalsis, and the presence of sustained uterine contractions. Uterine peristalsis was identifiable in 3/10, 3/13, and 3/3 of the endometriosis patients in each menstrual cycle, respectively, and in 11/12, 3/12, and 5/12 of their control subjects. Peristaltic detection rate and frequency were significantly less for the endometriosis group than for the controls in the periovulatory phase only (p<0.05). Sustained contractions were recognized in 19/36 control subjects and in 13/26 endometriosis patients, but the difference was not significant. Uterine peristalsis appears to be suppressed during the periovulatory phase in patients with endometriosis, which may have an adverse effect on sperm transport.

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Section: Image Analysis Of Uterine Peristalsismentioning

confidence: 99%

Cine MR imaging of uterine peristalsis in patients with endometriosis

Kido

Togashi

Nishino³

et al. 2006

Eur Radiol

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“…Neither diffuse nor focal thickness change more than 1 pixel (= 1.17 mm) in the inner myometrium layer, of which thickness ranged from 2 to 3 pixels in this digital measurement, was also observed throughout all menstrual cycle phases. It has been reported that the decrease in blood volume and water content in the myometrium lowers its signal intensity in T2WI (Togashi et al 1993;Kataoka et al 2005). Thus, it seems reasonable to say that the decrease in blood volume and water content was not responsible for the ssES-induced reduction of the myometrium thickness in either outer or inner myometrium layers.…”

Section: Morphological Changes Of the Uterus Induced By Sses In T2wimentioning

confidence: 99%

Magnetic Resonance Imaging of Morphological and Functional Changes of the Uterus Induced by Sacral Surface Electrical Stimulation

Ogura

Murakami

Ozawa

et al. 2006

Tohoku J. Exp. Med.

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The purpose of this study is to examine the morphological and kinematical changes of the uterus induced by electrical stimulation applied to the skin just above the second and fourth posterior sacral foramens (sacral surface electrical stimulation [ssES]) in 26 healthy subjects. Out of them, eight subjects who had severe pain subjectively during every menstruation received ssES just in menstruation. Morphological and functional changes of the uterus were examined by using T2-weighted magnetic resonance (MR) imaging and T1-weighted MR cinematography, respectively. Cyclic electrical stimulation for 15 min with 5 sec ON and 5 sec OFF was applied just before MR scanning. A decrease in thickness of the muscular layer of the uterus was observed in every subject after ssES for 15 min and was significant as compared with the thickness before ssES. Periodic uterine movement during menstruation was observed in the subjects with severe menstrual pain in MR cine and the power spectrum analysis of the movement showed a marked decrease in peak power and frequency after ssES treatment. We conclude that ssES causes a reduction of static muscle tension of the uterus in all menstrual cycle periods and suppression of uterine peristalsis during menstruation in the subjects with severe menstrual pain. Possible neural mechanisms for these static and dynamic effects of ssES on the uterus at spinal level are discussed.sacral surface electrical stimulation; uterus; MRI; neuromodulation © 2006 Tohoku University Medical PressThe contractile component of the uterine wall is the myometrium which is composed of smooth muscles. The myometrium regulates tension of the uterine wall and peristaltic movements of the uterus under control of the autonomic nervous system. The pelvic organs are controlled by the hypogastric nerves (sympathetic) and pelvic nerves (parasympathetic) which are, in general,

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“…Some of the unwanted but frequently observed results of myometrial dysfunction are contractions that are not timed leading to abortions or preterm delivery, or stronger than necessary contractions causing foetal distress, hypoxia and even death of the foetus (Aguilar & Mitchell 2010;Wray 2007). The nonpregnant myometrium exhibits contractions at different phases of the menstrual cycle; these include rhythmic, 'wavelike' contractions, oftentimes referred to as uterine peristalsis or spontaneous contractions, and the 'focal and sporadic bulging of the myometrium' (Togashi 2007;Togashi et al 1993), leading to sustained contractions. These contractions are important in endometrial sloughing (Wray & Noble 2008) and assist in sperm passage (Pehlivanoğlu, Bayrak & Doğan 2013).…”

Section: Discussionmentioning

confidence: 99%

<i>Dryopteris filix-mas</i> (Dryopteridaceae) leaves inhibit mouse uterine activity

Bafor

Omokaro

Uwumarongie³

et al. 2017

JOMPED

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Background: The plant Dryopteris filix-mas has been used traditionally for its uterine-stimulant effects.Aim: The current study is therefore aimed at investigating and determining the effect of the leaves of D. filix-mas on uterine contractility in vitro.Setting: Fresh leaves of D. filix-mas were collected from a river bank in the south-western part of Nigeria.Methods: The leaves of D. filix-mas were cleaned, dried and extracted in methanol. The extract (0.07 µg/mL–21.0 µg/mL) was tested on the isolated mouse uteri in order to determine activity on spontaneous-induced uterine contractions. Subsequently the extract (0.005 mg/mL and 0.05 mg/mL) was tested on oxytocin-induced contraction (0.00017 ng/mL–4.98 ng/mL) in calcium-containing media, submaximal oxytocin-induced contraction (0.116 ng/mL) in calcium-free media and in the presence of high KCl-induced uterine contractions (80 mM). The extract was also subjected to mass spectrometric determination of secondary metabolites.Results: The plant extract inhibited spontaneous-induced contractions with IC50 amplitude = 658.41 ng/mL ± 0.11 ng/mL and IC50 frequency = 175.32 ng/mL ± 0.53 ng/mL. The plant extract inhibited oxytocin-induced and high KCl-induced uterine contractions (p < 0.01 at 0.5 mg/mL). The plant extract had no effect on oxytocin-induced contractions under calcium-free conditions. Secondary metabolites belonging to classes of fatty acids, alkaloids, saponin glycosides, amino acids, limonoids, terpenes and porphyrins were identified.Conclusion: The current study reports an inhibitory effect of the plant on uterine contractility in this study, suggesting possible application as a tocolytic or as a contraceptive, as most contraceptive plants have shown uterine-relaxing effect.

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Sustained uterine contractions: a cause of hypointense myometrial bulging.

Cited by 56 publications

References 0 publications

Cine MR imaging of uterine peristalsis in patients with endometriosis

Cine MR imaging of uterine peristalsis in patients with endometriosis

Magnetic Resonance Imaging of Morphological and Functional Changes of the Uterus Induced by Sacral Surface Electrical Stimulation

<i>Dryopteris filix-mas</i> (Dryopteridaceae) leaves inhibit mouse uterine activity

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