This study aims to identify the contextual relationships between the impact factors on Sustainability 4.0, through the principles of I4.0 in the textile industry, using interpretive structural modeling (ISM), a qualitative technique that makes it possible to understand the relationship between different factors, classifying them hierarchically based on their interdependencies. The hierarchy of the 16 (sixteen) factors proposed at different levels helps to identify critical areas to focus efforts and investments, providing data to guide strategic business planning. From the result of the Level Partition Chart, four levels were observed for the ISM diagram. The Corporate Social Responsibility factor (FIS7) was considered a dependent variable of all others. The identification of FIS4, FIS10 and FIS14 as factors with high dependence suggests key areas for strategic interventions. Thus, this study provides a solid theoretical basis and practical recommendations that help textile companies adopt sustainable and technologically advanced strategies, promoting an effective transition to Sustainability 4.0.