Suture Cells in a Mechanical Stretching Niche: Critical Contributors to Trans-sutural Distraction Osteogenesis

Liang, Wei; Zhao, Enzhe; Guan, Li; Bi, Hongsen; Zhao, Zhihui

doi:10.1007/s00223-021-00927-z

Cited by 4 publications

(2 citation statements)

References 101 publications

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“…The structure of the palatal suture in the posterior region of rats is similar to that of humans, with secondary cartilage along the palatine bone edges and a thin layer of fibers in the core, with suture-derived stem cells (SuSCs) in the center [ 3 , 32 ]. SuSCs are a unique functional population that possess an intrinsic ability to differentiate into osteoblasts, chondrocytes, and fibroblasts[ 33 ]. The mechanical stretching force of suture expansion causes macrophages infiltrate into the midpalatal suture within 24 h [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Extracellular vesicles derived from M1 macrophages enhance rat midpalatal suture expansion by promoting initial bone turnover and inflammation

Liu,

Zhong,

Zheng

et al. 2023

Prog Orthod.

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Background Midpalatal suture (MPS) expansion can be affected by many factors, and researchers have attempted to regulate the initial inflammatory stage of expansion to optimize clinical outcomes and their underlying mechanisms. This study aimed to investigate the potential effects and mechanisms of M1 macrophage small extracellular vesicles during rat MPS expansion. Materials and methods RAW264.7 cells were induced to M1 or M2 polarization and, small extracellular vesicles were isolated from the polarized macrophages. Male Sprague–Dawley rats (6–7 weeks) were administered 70 ± 5 g expansion force devices for 7 days. Rats with expanders without force served as controls. M1/M2 small extracellular vesicles were injected into the MPS region (50 µg/day) in the M1 and M2 small extracellular vesicle-assisted groups, while 0.9% saline was injected into the expansion-only group. Suture width, bone mass, and morphological changes in the region of interest (ROI) were examined. Results The M1 small extracellular vesicle-assisted group showed a significantly increased MPS suture width in vivo (P < 0.001), and less bone mass was observed in the ROI (P < 0.05). Histological examination showed that the M1 small extracellular vesicle-assisted group exhibited a wider palatal area and obvious fibrous tissue rearrangement. The expression of RANKL and the number of osteoclasts were increased (P < 0.01) in the bony edges, and the p65 protein expression was significantly higher (P < 0.001). Conclusions M1 macrophage-derived small extracellular vesicles have a positive effect in MPS expansion and increase p65 protein content and RANKL expression, thus promoting bone turnover. This study may contribute to the clinical application of small extracellular vesicles in the expansion of the palatal suture.

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Section: Discussionmentioning

confidence: 99%

Extracellular vesicles derived from M1 macrophages enhance rat midpalatal suture expansion by promoting initial bone turnover and inflammation

Liu,

Zhong,

Zheng

et al. 2023

Prog Orthod.

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show abstract

“…Recently, researchers have focused on the molecular mechanism of DOME in the treatment of cleft lip and palate, suggesting that fibroblasts in the zygomatic maxillary suture transform into a vascular endothelium-like state in response to mechanical stimulation, promoting angiogenesis under tension, while secreting signal molecules to interact with other cell types and promote osteogenesis ( 46 , 47 ). Further research is needed, however, on the mechanistic immune status of craniofacial sutures and the interactions between immune cells and other cell types ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of research on craniomaxillofacial distraction osteogenesis from 2000 to 2021

Liu

Yang²,

Zhou³

et al. 2022

Front. Surg.

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ObjectiveThis study collected and summarized publications related to craniomaxillofacial distraction osteogenesis(DO) from 2000 to 2021, investigated trends in related research, and compared publications from different countries, institutions and journals. The aim is showcasing hotspots and frontiers in the field and providing a reference for future research.BackgroundCraniomaxillofacial DO serves to treat different types of craniomaxillofacial dysplasia and bone defects and deformities. DO can significantly reduce surgical trauma, complications, and recurrence rate compared to conventional surgery. However, there is a lack of bibliometric analyses regarding Craniomaxillofacial DO.MethodsCiteSpace and VOSviewer were used to analyze and visualize 3,141 articles and reviews searching through the Web of Science Core Collection(WOSCC) to obtain publications on craniomaxillofacial DO from 1 January 2000 to 31 December 2021.ResultsIn the last 21 years, there has been a significant increase in the number of publications. The United States, the People's Republic of China, and Italy produce the vast majority of publications. University of Milan and University of Bologna are the most influential in this field. McCarthy JG is the most influential author. Obstructive sleep apnea, TMJ ankylosis and cleft lip and palate are potential research direction in this field.ConclusionFuture research should focus on the precise indications and optimal timing of craniomaxillofacial DO and the evaluation of the long-term outcomes of various modified procedures. This study provides a relatively objective reference for related researchers, medical practitioners, and global health systems.

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RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesis

Ye,

Wang,

Zhao

et al. 2024

Cellular Signalling

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Suture Cells in a Mechanical Stretching Niche: Critical Contributors to Trans-sutural Distraction Osteogenesis

Cited by 4 publications

References 101 publications

Extracellular vesicles derived from M1 macrophages enhance rat midpalatal suture expansion by promoting initial bone turnover and inflammation

Extracellular vesicles derived from M1 macrophages enhance rat midpalatal suture expansion by promoting initial bone turnover and inflammation

A bibliometric analysis of research on craniomaxillofacial distraction osteogenesis from 2000 to 2021

RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesis

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