Sutureless avascular meniscal repair with a photoactive naphthalimide compound: A preliminary animal study

Pollo, Fabian E.; Jackson, Robert W.; Kane, Robert R.; Chang, Hui Min; Zhang, Jianxing; Dieterichs, Chad; Riedel, Stefan

doi:10.1016/j.arthro.2004.07.002

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Nevertheless, thermal damage is still possible if the irradiance of laser is high as demonstrated in previous studies. 2,41 In the skin bonding study, maximal temperature at the skin surface increased rapidly to >608C at a higher irradiance (1.68 W/cm 2 ) but maintained <408C at lower irradiances (1 W/cm 2 ). This high irradiance was found to be correlated to the presence of cell necrosis and collagen denaturation in the photochemically bonded skin samples.…”

Section: Potential Toxicities and Remediesmentioning

confidence: 98%

“…Over the last decade, the feasibility and safety of using PTB in repairing multiple tissue systems in skin, 2,38 cornea, 39,40 meniscus, 41,42 tendon, 3 blood vessel, 43 and nerve 44,45 have been demonstrated. PTB shares the same mechanism with PDT because of the similarity in tissue-light interactions and the same photosensitizer systems used such as xanthenes 2,3,[38][39][40][43][44][45] and naphthalimides, 41,42,46 and similar light sources using visible lasers. Unlike PDT, extracellular matrix such as collagen, rather than cells, is the main target molecule for bonding in PTB, based on early studies demonstrating the photochemical crosslinking effect of collagen type I fibrils or other proteins.…”

Section: Photochemical Tissue Bonding In Biosurgerymentioning

confidence: 99%

“…Unlike PDT, extracellular matrix such as collagen, rather than cells, is the main target molecule for bonding in PTB, based on early studies demonstrating the photochemical crosslinking effect of collagen type I fibrils or other proteins. 47,48 Although cells at tissue edges or surfaces are not the main targets for PTB, cell damage has been reported in the bonded tissues, including meniscus 41 and skin. 2 Such cell damage has been suggested to associate with the thermal toxicity of laser irradiation at high irradiances (1.68 and 1.8 W/cm 2 ) 2,41 and the inherent photosensitizer toxicity.…”

Section: Photochemical Tissue Bonding In Biosurgerymentioning

confidence: 99%

“…2 Such cell damage has been suggested to associate with the thermal toxicity of laser irradiation at high irradiances (1.68 and 1.8 W/cm 2 ) 2,41 and the inherent photosensitizer toxicity. 41 Similar to PDT, light and photosensitizer doses are important parameters determining the effectiveness of PTB. It is generally agreed that photosensitizer dosage 2,3,39,40,42 and laser fluence rate ( J/cm 2 ) 2,3,42 significantly affect the outcomes of PTB in terms of mechanical properties of tendon and menisci, 3,42 adherence properties of skin grafts, 2 and intraocular pressure of cornea.…”

Section: Photochemical Tissue Bonding In Biosurgerymentioning

confidence: 99%

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Biomedical Applications of Photochemistry

Chan

2010

Tissue Engineering Part B: Reviews

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Photochemistry is the study of photochemical reactions between light and molecules. Recently, there have been increasing interests in using photochemical reactions in the fields of biomaterials and tissue engineering. This work revisits the components and mechanisms of photochemistry and reviews biomedical applications of photochemistry in various disciplines, including oncology, molecular biology, and biosurgery, with particular emphasis on tissue engineering. Finally, potential toxicities and research opportunities in this field are discussed.

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Section: Potential Toxicities and Remediesmentioning

confidence: 98%

Section: Photochemical Tissue Bonding In Biosurgerymentioning

confidence: 99%

Section: Photochemical Tissue Bonding In Biosurgerymentioning

confidence: 99%

Section: Photochemical Tissue Bonding In Biosurgerymentioning

confidence: 99%

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Biomedical Applications of Photochemistry

Chan

2010

Tissue Engineering Part B: Reviews

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The knee meniscus: Structure–function, pathophysiology, current repair techniques, and prospects for regeneration

2011

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Extensive scientific investigations in recent decades have established the anatomical, biomechanical, and functional importance that the meniscus holds within the knee joint. As a vital part of the joint, it acts to prevent the deterioration and degeneration of articular cartilage, and the onset and development of osteoarthritis. For this reason, research into meniscus repair has been the recipient of particular interest from the orthopedic and bioengineering communities. Current repair techniques are only effective in treating lesions located in the peripheral vascularized region of the meniscus. Healing lesions found in the inner avascular region, which functions under a highly demanding mechanical environment, is considered to be a significant challenge. An adequate treatment approach has yet to be established, though many attempts have been undertaken. The current primary method for treatment is partial meniscectomy, which commonly results in the progressive development of osteoarthritis. This drawback has shifted research interest towards the fields of biomaterials and bioengineering, where it is hoped that meniscal deterioration can be tackled with the help of tissue engineering. So far, different approaches and strategies have contributed to the in vitro generation of meniscus constructs, which are capable of restoring meniscal lesions to some extent, both functionally as well as anatomically. The selection of the appropriate cell source (autologous, allogeneic, or xenogeneic cells, or stem cells) is undoubtedly regarded as key to successful meniscal tissue engineering. Furthermore, a large variation of scaffolds for tissue engineering have been proposed and produced in experimental and clinical studies, although a few problems with these (e.g., byproducts of degradation, stress shielding) have shifted research interest towards new strategies (e.g., scaffoldless approaches, self-assembly). A large number of different chemical (e.g., TGF-β1, C-ABC) and mechanical stimuli (e.g., direct compression, hydrostatic pressure) have also been investigated, both in terms of encouraging functional tissue formation, as well as in differentiating stem cells. Even though the problems accompanying meniscus tissue engineering research are considerable, we are undoubtedly in the dawn of a new era, whereby recent advances in biology, engineering, and medicine are leading to the successful treatment of meniscal lesions.

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