Suxamethonium pains and early electrolyte changes

Collier, Clive

doi:10.1111/j.1365-2044.1978.tb12464.x

Cited by 47 publications

(15 citation statements)

References 25 publications

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“…This is in keeping with the previously pubIished reports (Keneally & Bush 1974;Henning & Bush 1982;Dierdorf et a2.1984). The small decreases in total calcium levels following suxamethonium administration confirm the findings of other workers (Bourke & Rosenberg 1978;Collier 1978). In the present study these were similar in strabismus and tonsillectomy patients and were related to suxamethonium administration, but in contrast to CK and potassium changes, were similar with halothane and thiopentone administration.…”

Section: Discussionsupporting

confidence: 93%

Changes in serum potassium, calcium and creatine kinase following suxamethonium administration in children with and without strabismus

McLoughlin

Mirakhur

Elliott

et al. 1991

Pediatric Anesthesia

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The immediate changes in serum potassium and calcium and 2 4 h changes in creatine kinase (CK) following suxamethonium administration were compared in children undergoing strabismus repair or tonsillectomy following induction of anaesthesia with thiopentone or halothane. A separate group of children were anaesthetized with isoflurane and did not receive suxamethonium.There was a sigruficant increase (P < 0.05) in serum potassium of 0.26 and 0.56 mmol.l-' following halothane-suxamethonium induction and a sigruficant decrease ( P < 0.05) of 0.35 and 0.13 mmol.1-' after thiopentone-suxamethonium induction in the strabismus and tonsillectomy groups respectively. There was an increase in the 24 h CK values of 624 and 694 u.1-I (P < 0.05) in patients receiving halothane-swamethonium induction and of 43 (NS) and 247 u.1-I (P < 0.05) in patients receiving thiopentone-suxamethonium induction in the strabismus and tonsillectomy groups respectively. Suxamethonium administration was associated with a small but sometimes sigruficant ( P < 0.05) decrease in total serum calcium concentrations (0.036 to 0.049 mmol-1-'). Changes in all indices were minimal in children anaesthetized with isoflurane. It is concluded that the administration of halothane and suxamethonium is the main cause for the changes in serum potassium and CK and not the presence of strabismus.

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Section: Discussionsupporting

confidence: 93%

Changes in serum potassium, calcium and creatine kinase following suxamethonium administration in children with and without strabismus

McLoughlin

Mirakhur

Elliott

et al. 1991

Pediatric Anesthesia

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“…*' A decrease in serum calcium one minute after suxamethoniurn administration has been noted and Collier postulated that influx of calcium into the muscle caused vigorous and damaging contractions. 22 We suggest that there may be parallels between this calcium influx after suxamethonium, with that observed in experimentally-induced muscle damage. Jackson and J o n q Z 3 using electrically stimulated isolated muscle preparations, showed that calcium uptake into the muscle occurred and that this is bound to calmodulin causing activation of phospholipase A2 (Fig.…”

Section: Discussinnmentioning

confidence: 52%

Suxamethonium induced myalgia and the effect of pre‐operative administration of oral aspirin

McLoughlin¹,

Nesbitt²,

Howe³

1988

Anaesthesia

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SummaryEighty:four j t , unpremedicated patients who presented .for routine surgery and received a standard anaesthetic technique were alloccited randomly to three equal groups. Group I received tubocurarine 0.05 rnglkg before induction of anaesthesia. Group 2 received soluble aspirin 600 mg orally one hour before surgery, while Group 3 received no pretreatment. Aspirin prophylaxis prothrced a signijkant reduction in the incidence of subsequent suxamethonium-induced myalgia and the improvement was similar to that achieved with tubocurarine pretreatment. Pre-operative oral administration of aspirin effectively reduces muscle pain., and avoids many of the complications associated with pretreatment with non-depolarising agents.

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“…Collier observed a transient fall in serum calcium levels at 1 min, following succinylcholine administration in patients who had postoperative myalgia and postulated that influx of calcium in to muscle cells caused an increase in muscle damage and pains. [21] Magnesium affects the neuromuscular junction and competes with calcium at prejunctional site. These both ions antagonize each other—high magnesium concentrations inhibit release of acetylcholine, while high calcium concentration increases the release of acetylcholine from the presynaptic nerve terminals.…”

Section: Discussionmentioning

confidence: 99%

Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia

Kumar

Talwar

Goyal

et al. 2012

J Anaesthesiol Clin Pharmacol

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Background:Magnesium sulfate and propofol have been found to be effective against succinylcholine-induced fasciculations and myalgia, respectively, in separate studies. A prospective randomized double blind controlled study was designed to assess the effect of a combination of magnesium sulfate with propofol for induction of anesthesia on succinylcholine-induced fasciculations and myalgia.Materials and Methods:Randomly selected 60 adult patients scheduled for elective surgery under general anesthesia were allocated to one of the two equal groups by draw of lots. The patients of MG Group were pretreated with magnesium sulfate 40 mg/kg body weight in 10 ml volume, while patients of NS group were given isotonic saline 0.9% in the same volume (10 ml) intravenously slowly over a period of 10 min. Anesthesia was induced with fentanyl 1.5 mcg/kg and propofol 2 mg/kg, followed by administration of succinylcholine 2 mg/kg intravenously. Muscle fasciculations were observed and graded as nil, mild, moderate, or severe. Postoperative myalgia was assessed after 24 h of surgery and graded as nil, mild, moderate, or severe. Observations were made in double blind manner.Results:Demographic data of both groups were comparable (P > 0.05). Muscle fasciculations occurred in 50% patients of MG group versus in 100% patients of NS group with a significant difference (P < 0.001). After 24 h of surgery, no patient of MG group and 30% patients of NS group had myalgia with a significant difference (P < 0.002).Conclusion:Magnesium sulfate 40 mg/kg intravenously may be used with propofol for induction of anesthesia to control succinylcholine-induced fasciculations and myalgia.

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Suxamethonium pains and early electrolyte changes

Cited by 47 publications

References 25 publications

Changes in serum potassium, calcium and creatine kinase following suxamethonium administration in children with and without strabismus

Changes in serum potassium, calcium and creatine kinase following suxamethonium administration in children with and without strabismus

Suxamethonium induced myalgia and the effect of pre‐operative administration of oral aspirin

Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia

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