sVCAM-1, sICAM-1, TNF-α and IL-6 levels in bipolar disorder type I: Acute, longitudinal and therapeutic implications

Pantović-Stefanović, Maja; Petronijević, Nataša; Dunjić-Kostić, Bojana; Velimirović, M.; Nikolić, Tatjana; Jurišić, Vladimir; Lačković, Milena; Damjanović, Aleksandar; Totić-Poznanović, Sanja; Jovanović, Aleksandar; Ivković, Maja

doi:10.1080/15622975.2016.1259498

Cited by 28 publications

(25 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is of particular interest in psychiatric disorders for two reasons: It has a key function for the blood-brain barrier, which plays an important role in the biology of psychiatric disorders, and it is a marker for in ammation [38]. High soluble ICAM (sICAM) levels were found during both the depressed and the manic states and also during the euthymic phase in bipolar disorder [39].…”

Section: Discussionmentioning

confidence: 99%

A Functional SNP rs895819 on Pre-miR-27a is Associated with Bipolar Disorder by Targeting ICAM-1.

Yang¹,

Lu²,

Mei³

et al. 2021

Preprint

View full text Add to dashboard Cite

Aberrant expression or genomic mutations of microRNA have been reported to be associated with a variety of human diseases. This study is aimed to analyze the association between genetic variations of miRNA and schizophrenia or bipolar disorder. We performed case-control studies for ten SNPs in a total sample of 1584 Chinese subjects. All these ten SNPs are on or near mature microRNAs which are expressed in the brain. To illustrate the function of miR-27a, we constructed a miR-27a knockout (KO) astrocytoma cell line U-251MG. By comparing the differentially expressed genes in wild-type and KO U-251MG, we determined several candidate target genes of miR-27a and then verified ICAM-1 as a target gene of miR-27a. We identified the association between the T/C polymorphism at rs895819 and bipolar disorder. Ectopic expression of miR-27a in NPCs showed that the T to C mutation at rs895819 reduced the suppressive effects of miR-27a on the expression of its target genes. Further studies revealed that the T/C polymorphism on miR-27a led to differential expression of mature and precursor miR-27a without affecting the expression of primary miR-27a. Our study highlighted the importance of miR-27a and its polymorphism at rs895819 in bipolar disorder.

show abstract

Section: Discussionmentioning

confidence: 99%

A Functional SNP rs895819 on Pre-miR-27a is Associated with Bipolar Disorder by Targeting ICAM-1.

Yang¹,

Lu²,

Mei³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…One study found a weak positive correlation between sICAM-1 levels and the scores on the Yale Mania Rating Scale in patients in a manic state (Turan et al, 2014). In their study in patients with bipolar disorder (n = 83), another group of researchers described higher blood levels of sICAM-1 (and higher IL-6, but lower tumor necrosis factor-α and lower sVCAM) in both acute and remission phases of the disorder than in age-, sex-, and body-mass–matched healthy controls (n = 73) (Pantovic-Stefanovic et al, 2016). Similarly, another study found significantly higher blood levels of sICAM-1 in euthymic bipolar patients than in healthy controls (Reininghaus et al, 2016).…”

Section: Icam-1 In Psychiatric Disordersmentioning

confidence: 99%

The Role of Intercellular Adhesion Molecule-1 in the Pathogenesis of Psychiatric Disorders

2019

View full text Add to dashboard Cite

Intercellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein that is overexpressed in many pathological states. Although, like many other immune molecules, ICAM-1 plays only a limited role in the abundant concert of the immune response, it may be more important than we realize. In the central nervous system (CNS), ICAM-1 is expressed in microglial cells and astrocytes and in endothelial cells in the white and gray matter of the human forebrain. It is of particular interest in psychiatric disorders for two reasons: It has a key function for the blood–brain barrier, which plays an important role in the biology of psychiatric disorders, and it is a marker for inflammation. Although the blood level of soluble ICAM-1 (sICAM-1) might be lower in acute unmedicated schizophrenia, it has been reported to be increased in many other psychiatric conditions, such as major depression, bipolar disorder, and dementia. In bipolar disorder, high sICAM levels were found during both the depressed and the manic states and also during the euthymic phase (the free interval), possibly indicating that sICAM is a trait marker. High sICAM-1 blood levels have also been found in depression comorbid to a somatic disease state. Interestingly, sICAM-1 levels also increase during aging. Some studies investigated sICAM-1 levels in the cerebrospinal fluid of psychiatric disorders and ICAM-1 expression in postmortem CNS tissue of psychiatric patients and found that the overall duration and duration of the chronic phase of the psychiatric disorder seem to play a role in both. Moreover, confounders, such as antipsychotic and antidepressive medication, have to be considered. sICAM-1 levels seem to be associated with hypopermeability or hyperpermeability of the blood-brain barrier and thus to influence the communication between the CNS immune system, represented by glia cells, and the peripheral immune system. The balance between the influx and efflux of immune molecules into and out of the CNS may be one of the pinpoints in psychiatric disorders, in particular in the chronic phase, e.g., in schizophrenia. This aspect, however, needs further intense research, in particular to enable researchers to develop therapeutic principles based on an immune/inflammatory approach.

show abstract

“…The cytokine network is activated to produce a large number of cytokines closely related to the development of inflammation in sepsis patients [4,5]. Among the inflammatory mediators involved, tumor necrosis factor alpha (TNF-α) is the closest mediator of the cytokine cascade.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Effect of an Anti-TNF-α/HSA/IL-6R Triple-Specific Fusion Protein Under Experimental Septic Conditions

et al. 2022

View full text Add to dashboard Cite

Sepsis caused by a dysregulated host response to infection is a life-threatening disease that can lead to organ dysfunction. Due to its unclear and complex mechanism, effective medicine for the treatment of sepsis is urgently required. The extensive release of cytokines and other mediators like TNF-α and interleukin-6 (IL-6) play critical roles in the development of sepsis. The present study aims to evaluate the potential protective effects of an anti-TNF-α/HSA/IL-6R triple-specific fusion protein (TAL-6) under septic experimental conditions. The anti-TNF-α/ HSA/IL-6R triple-specific fusion protein (TAL-6), which links three published single domain antibodies, was designed and constructed in our lab. High purity fusion proteins were obtained with high binding affinity for TNF-α (94.75 pM), human serum albumin (1.83 nM) and IL-6R (2.29 nM). TAL-6 protected mouse fibroblast fibrosarcoma cells (L929) from apoptosis induced by TNF-α, establishing that the expressed fusion proteins can selectively interact with TNF-α in vitro. In vivo, the survival rate of cecal ligation and puncture (CLP) was notably increased in the group with TAL-6 treatment and significantly higher compared with the single-targeted IL-6R and TNF-α fusion protein at the same dose. After treatment with TAL-6, the serum levels of TNF-α, IL-1β, and IL-6 were significantly decreased, and sepsis-induced pathological injuries in the kidney were remarkably attenuated. TAL-6 is therefore a potential candidate for the development of new drugs against sepsis in human.

show abstract

sVCAM-1, sICAM-1, TNF-α and IL-6 levels in bipolar disorder type I: Acute, longitudinal and therapeutic implications

Abstract: BD is related to both acute and long-term alterations of immune mediators, including adhesion molecules. The potential immunomodulatory role of pharmacotherapeutic treatment is also to be considered in BD.

Cited by 28 publications

References 52 publications

A Functional SNP rs895819 on Pre-miR-27a is Associated with Bipolar Disorder by Targeting ICAM-1.

A Functional SNP rs895819 on Pre-miR-27a is Associated with Bipolar Disorder by Targeting ICAM-1.

The Role of Intercellular Adhesion Molecule-1 in the Pathogenesis of Psychiatric Disorders

The Therapeutic Effect of an Anti-TNF-α/HSA/IL-6R Triple-Specific Fusion Protein Under Experimental Septic Conditions

Contact Info

Product

Resources

About