Swallowed Fluticasone Improves Histologic but Not Symptomatic Response of Adults With Eosinophilic Esophagitis

Intrabolus Pressure Has Better Correlation Than Eosinophilia with Dysphagia Severity in Fibrostenotic Eosinophilic Esophagitis: A Pilot Study

“…This is supported by our observation in three of our patients whose mucosal eosinophilia remained unchanged while their dysphagia markedly improved following dilatation. Other studies, such as Alexander et al, found a similar discordance between esophageal eosinophilia and dysphagia severity [18]. These results question the significance of histologic response alone in EoE, particularly in those patients with fibrostentotic disease.…”

Delay in Diagnosis of Eosinophilic Esophagitis Increases Risk for Stricture Formation in a Time-Dependent Manner

“…While there is consensus among the members of scientific community and regulatory agencies that symptoms should be assessed by patients themselves [24,25], the extent of correlation between patient-reported outcomes and endoscopic and histologic findings has not yet been determined and needs to undergo further evaluation. [26][27][28][29] We addressed the potential issue of a referral bias by comparing the results of time-dependent stricture development in the group of 200 patients diagnosed by the senior author (AS) with the group of 460 externally diagnosed EoE patients. Although the assessment of endoscopic features at the time of EoE diagnosis was not standardized in this external cohort, we found, similarly to the results in the "core" cohort of 200 patients, that the prevalence of strictures at the time of EoE diagnosis significantly increased with ongoing duration of untreated disease.…”

Diagnosis and treatment of eosinophilic esophagitis in clinical practice

“…Second, a discrepancy exists between symptomatic and histologic remission. Some patients do not present symptom relief even after endoscopic and histological improvement has been achieved [59,110,111]. This discrepancy is likely attributed to the limited response of the sub-epithelial fibrosis and remodeling to the currently available medication.…”