Swarm Intelligence in Cell Entry Exclusion Phenomena in Viruses and Plasmids: How to Exploit Intelligent Gene Vector Self-Scattering in Therapeutic Gene Delivery

Tolmachov, Oleg

doi:10.1007/978-3-030-29022-1_10

Global Virology III: Virology in the 21st Century 2019

DOI: 10.1007/978-3-030-29022-1_10

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Swarm Intelligence in Cell Entry Exclusion Phenomena in Viruses and Plasmids: How to Exploit Intelligent Gene Vector Self-Scattering in Therapeutic Gene Delivery

Oleg Tolmachov

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2023

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Cellular and Natural Viral Engineering in Cognition-Based Evolution

Miller

Reber

Marshall³

et al. 2023

Communicative & Integrative Biology

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Neo-Darwinism conceptualizes evolution as the continuous succession of predominately random genetic variations disciplined by natural selection. In that frame, the primary interaction between cells and the virome is relegated to host-parasite dynamics governed by selective influences. Cognition-Based Evolution regards biological and evolutionary development as a reciprocating cognition-based informational interactome for the protection of self-referential cells. To sustain cellular homeorhesis, cognitive cells collaborate to assess the validity of ambiguous biological information. That collective interaction involves coordinate measurement, communication, and active deployment of resources as Natural Cellular Engineering. These coordinated activities drive multicellularity, biological development, and evolutionary change. The virome participates as the vital intercessory among the cellular domains to ensure their shared permanent perpetuation. The interactions between the virome and the cellular domains represent active virocellular cross-communications for the continual exchange of resources. Modular genetic transfers between viruses and cells carry bioactive potentials. Those exchanges are deployed as nonrandom flexible tools among the domains in their continuous confrontation with environmental stresses. This alternative framework fundamentally shifts our perspective on viral-cellular interactions, strengthening established principles of viral symbiogenesis. Pathogenesis can now be properly appraised as one expression of a range of outcomes between cells and viruses within a larger conceptual framework of Natural Viral Engineering as a co-engineering participant with cells. It is proposed that Natural Viral Engineering should be viewed as a co-existent facet of Natural Cellular Engineering within Cognition-Based Evolution.

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Cellular and Natural Viral Engineering in Cognition-Based Evolution

Miller

Reber

Marshall³

et al. 2023

Communicative & Integrative Biology

View full text Add to dashboard Cite

show abstract

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Swarm Intelligence in Cell Entry Exclusion Phenomena in Viruses and Plasmids: How to Exploit Intelligent Gene Vector Self-Scattering in Therapeutic Gene Delivery

Cited by 1 publication

References 36 publications

Cellular and Natural Viral Engineering in Cognition-Based Evolution

Cellular and Natural Viral Engineering in Cognition-Based Evolution

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