Sweat test for cystic fibrosis: Wearable sweat sensor vs. standard laboratory test

Choi, Dong-Hoon; Thaxton, A.; Jeong, In Cheol; Kim, Kain; Sosnay, Patrick R.; Cutting, Garry R.; Searson, Peter C.

doi:10.1016/j.jcf.2018.03.005

Cited by 67 publications

(66 citation statements)

References 12 publications

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“…Some of the most commonly measured analytes in sweat are electrolytes, such as sodium [15,17,25], potassium [3,26] and chloride [27,28]. Although sodium has been shown to be a useful marker for electrolyte imbalance [15], there is no evidence of any correlation between blood and sweat sodium [13].…”

Section: Sweat As a Biofluidmentioning

confidence: 99%

Wearable flexible sweat sensors for healthcare monitoring: a review

Chung

Fortunato

Radacsi

2019

J. R. Soc. Interface.

275

208

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The state-of-the-art in wearable flexible sensors (WFSs) for sweat analyte detection was investigated. Recent advances show the development of integrated, mechanically flexible and multiplexed sensor systems with on-site circuitry for signal processing and wireless data transmission. When compared with single-analyte sensors, such devices provide an opportunity to more accurately analyse analytes that are dependent on other parameters (such as sweat rate and pH) by improving calibration from in situ real-time analysis, while maintaining a lightweight and wearable design. Important health conditions can be monitored and on-demand regulating drugs can be delivered using integrated wearable systems but require correlation verification between sweat and blood measurements using in vivo validation tests before any clinical application can be considered. Improvements are necessary for device sensitivity, accuracy and repeatability to provide more reliable and personalized continuous measurements. With rapid recent development, it can be concluded that non-invasive WFSs for sweat analysis have only skimmed the surface of their health monitoring potential and further significant advancement is sure to be made in the medical field.

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Section: Sweat As a Biofluidmentioning

confidence: 99%

Wearable flexible sweat sensors for healthcare monitoring: a review

Chung

Fortunato

Radacsi

2019

J. R. Soc. Interface.

275

208

View full text Add to dashboard Cite

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“…Underlying cases for such serious maladies can be summarized as the lack of available analysis methods and subsequent treatment strategies due to the limited access of centralized and equipped health-care facilities [65]. Many researchers, such as physicists, chemists, biologists, and medical doctors, have used nanosensors as applications in several fields, including doping analysis [66], diagnosis [67], food safety [68], and laboratory medicine [69]. Among them, clinical applications have been researched as an impressive field of application.…”

Section: Significance Of Virus Detectionmentioning

confidence: 99%

Virus detection using nanosensors

Saylan

Deni̇zli̇

2020

Nanosensors for Smart Cities

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“…With the development of advancing technology and significant use in studies of CFTR modulators, other modalities are being investigated. One novel device, a wearable sensor connected via Bluetooth to mobile app, was tested in both patients with CF and nonaffected controls, revealing excellent correlation with conventional methodology, however, a much smaller volume was estimated to be needed (0.6 μL vs 15 μL) and results can be delivered in as little as 15 minutes . Alternatively, use of a ratio of C‐sweat (CFTR dependent sweating) and M‐sweat (CFTR independent sweating) was tested in both patients with CF and nonaffected controls, with C/M ratios revealing an almost linear relationship to CFTR function and genotype, demonstrating a C/M ratio of 0.0055 can discriminate between CF and non‐CF/carriers with 100% sensitivity and specificity …”

Section: Cftr Modulatorsmentioning

confidence: 99%