Sweet light o' mine: Photothermal and photodynamic inactivation of tenacious pathogens using conjugated polymers

Ponzio, Rodrigo Andrés; Ibarra, Luis Exequiel; Achilli, Estefanía Edith; Odella, Emmanuel; Chesta, Carlos A.; Martínez, Sol R.; Palacios, Rodrigo E.

doi:10.1016/j.jphotobiol.2022.112510

Cited by 17 publications

(7 citation statements)

References 198 publications

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“…Different polymeric nanomaterials, metal oxides, and porous nanomaterials show such effects. 51 Owing to their structure, morphology, and surface features, NMs can be classified into various types such as 1D-nanofibers, nanoribbons, nanorods, 2D-nanosheets and nano-petals, and 0D-quantum dots and nanoclusters. 52 Furthermore, some 3D nanomaterials like nanoflowers, nanoparticles, and nano-assemblies have gained attention due to their excellent structure-property correlation and superior functionality.…”

Section: Multimodal Photothermal Therapies Against Superbugsmentioning

confidence: 99%

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Roy

Guo

2023

J. Mater. Chem. B

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Section: Multimodal Photothermal Therapies Against Superbugsmentioning

confidence: 99%

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Roy

Guo

2023

J. Mater. Chem. B

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“…The review also looks at the existing methods and strategies for producing singlet oxygen in PDT as described by other authors. 12 The review concludes with an overview of the work of other authors on the design and development of fluorescent probes, conjugated polymers and their nanoparticles, and fluorescent conjugated polymers used in PDT for singlet oxygen generation.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

Singh,

Sen Gupta,

Bose

2024

Nanoscale

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“…In recent years, the use of conjugated polymer nanoparticles (CPNs) has experienced substantial growth in various technological and biomedical fields. Specifically, CPNs have proven to be effective and versatile theragnostic tools in advanced clinical applications, most notably in imaging-based diagnostics and therapies against pathogenic microbial infections − and cancer. − In particular, CPNs are active materials for the effective application of various therapeutic modalities, such as photodynamic, , photothermal, and sonodynamic therapies . This versatility makes them promising tools for advancing the frontiers of personalized medicine and improving clinical outcomes.…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Adsorption Mechanism of Rhodamine B onto Conjugated Polymeric Nanoparticles Using Isothermal Calorimetry and Monte Carlo Simulations

Ponzio,

Odella,

Prost

et al. 2024

J. Phys. Chem. C

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We present herein a comprehensive study on the thermodynamics of rhodamine B (RhB) adsorption onto poly(9,9dioctylfluorene-alt-benzothiadiazole) (F8BT) nanoparticles (NPs) dispersed in water using the isothermal calorimetric titration (ITC) technique. ITC experiments were carried out over a wide temperature range (5−65 °C), and the resulting thermograms were subjected to a detailed thermodynamic analysis using different adsorption models. For this purpose, we developed a versatile computational code based on the Monte Carlo method. We found that the thermograms obtained at the different temperatures cannot be interpreted using the Langmuir, bi-Langmuir, or Brunauer, Emmet, Teller (BET) models. However, excellent thermogram fits were attained by applying the Langmuir model coupled with the formation of a RhB dimer on the surface of F8BT NPs. Using this model, the best fit to the experimental data at 25 °C yielded the following parameters for direct RhB adsorption on the F8BT NPs surface: equilibrium constant (K l ) of ∼2 × 10 7 M −1 , enthalpy change (ΔH l ) of ∼1 kJ mol −1 , and entropy change (ΔS l ) of ∼140 J K −1 mol −1 . These results indicate that dye adsorption is predominantly an entropy-controlled process. The fit also provided parameters associated with the formation of a second dye adsorption layer, i.e., the formation of the RhB dimer on the F8BT NPs surface, revealing values of ∼1.7 × 10 5 M −1 , ca. −20 kJ mol −1 , and ∼30 J K −1 mol −1 for K m , ΔH m , and ΔS m , respectively. The latter two parameters are similar to those previously reported for RhB dimer formation in water (ΔH d = −12 kJ mol −1 and ΔS d = 22 J K −1 mol −1 ) supporting the chosen Langmuir-dimer model. The analysis of the thermograms also suggests that the NPs surface available for RhB adsorption is small, as compared to the total surface, and that it decreases with decreasing temperature. The latter observation is intriguing, especially since the F8BT NPs hydrodynamic diameter shows only a small decrease with decreasing temperature. To explain these results, we propose that the surface of the NPs harbors highly hydrated polar groups that reduce the accessibility of the dye for adsorption.

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Sweet light o' mine: Photothermal and photodynamic inactivation of tenacious pathogens using conjugated polymers

Cited by 17 publications

References 198 publications

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

Unraveling the Adsorption Mechanism of Rhodamine B onto Conjugated Polymeric Nanoparticles Using Isothermal Calorimetry and Monte Carlo Simulations

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