Sweet's Syndrome and Acute Myeloid Leukæmia

“…40 Sweet's syndrome associated with AML is present at diagnosis in most cases and is often the presenting sign of AML. [43][44][45][46] The clinical features of AML-associated Sweet's syndrome differ from those of the idiopathic syndrome. Men and women are equally affected and the median age is 45 years.…”

Section: Sweet's Syndromementioning

confidence: 99%

Uncommon patterns of presentation of leukemia

Vidal

Bloomfield

1999

Hematol. Oncol.

View full text Add to dashboard Cite

“…11-14 SS may also occur as a paraneoplastic condition in other hematological conditions such as myelodysplastic syndrome (MDS), B and T cell non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL), multiple myeloma (MM), myeloproliferative neoplasms (MPN), or in the setting of visceral malignancies such as genitourinary, breast or colorectal cancer. In MA-SS the cutaneous manifestations of SS can occur before, during or after the diagnosis of the malignancy and thus its onset may herald the diagnosis of malignancy in individuals with no prior malignancy or may indicate a recurrence in patients with a prior history of cancer.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Sweet Syndrome in Patients With Acute Myeloid Leukemia

Kazmi

Pemmaraju

Patel

et al. 2015

Clinical Lymphoma Myeloma and Leukemia

View full text Add to dashboard Cite

Introduction Sweet's syndrome (SS) is associated with hematologic malignancies including acute myeloid leukemia (AML). Methods Patients with AML treated at our institution were reviewed to identify those with SS. Patient characteristics, laboratory values, and cytogenetic and molecular abnormalities were retrospectively reviewed. Results We identified 21 out of 2,178 (1%) AML patients that demonstrated clinical signs and symptoms, and histological features consistent with SS. Eleven patients (52%) were classified as AML with myelodysplasia-related features while three patients had therapy-related AML. Three patients had received treatment with granulocyte colony stimulation factor, one patient liposomal all-trans retinoic acid and two patients received hypomethylating agents prior to development of SS. Cytogenetic analysis revealed diploid karyotype in seven patients (33%), -5/del(5q) in eight patients {38%; three patients had -5/del(5q) as sole abnormality and five patients had -5/del(5q) as part of complex cytogenetics}, and complex cytogenetics in five patients (24%). Gene mutations in fms-related tyrosine kinase-3 (FLT3) gene were identified in seven of 18 evaluable patients (39%), including FLT3 –internal tandem duplication in four patients and FLT3 -D835 tyrosine kinase domain mutation in three patients. Conclusions SS occurs in 1% of AML patients; -5/del(5q) karyotype, FLT3 mutations, and AML with myelodysplasia-related features were more frequent among patients with SS.

show abstract

Sweet's Syndrome and Acute Myeloid Leukæmia

Cited by 42 publications

References 7 publications

Acute febrile neutrophilic dermatosis (Sweet-s syndrome) and myeloproliferative disorders

Acute febrile neutrophilic dermatosis (Sweet-s syndrome) and myeloproliferative disorders

Uncommon patterns of presentation of leukemia

Characteristics of Sweet Syndrome in Patients With Acute Myeloid Leukemia

Contact Info

Product

Resources

About