Sweet's syndrome in a patient with squamous cell carcinoma in terminal of an agnogenic myeloid bone marrow metaplasia

Abstract

hig .;. ii_ I., • \lf>. P(x)rly formed tubules and clusters of pleomorphic tumor cells are seen. cytic infiltration and Paget cells were not apparent (Fig. 2). The patient underwent left radical mastectomy and axillary curettage. Postoperative histologic examination showed the features of nuclear ducta] carcinoma in the mammary tissue and infiltration into the pectoral muscle and skin. Metastases and reactive changes have been seen in the regional lymph nodes as well. The stage of the tumor was evaluated as IIIB: T4N3M,,. The patient was referred for radiation therapy after the operation.Male breast cancer is a rare tumor accounting for only 1% of all breast cancers [I]. In situ ductal carcinoma is 0-7% of male breast cancer [2]. The few clinical studies on male breast cancer suggest that the tumor behaves like female breast cancer. Epidemiological studies of breast cancer in men have provided insights into the pathogenesis and etiology of breast cancer in both sexes. According to previous reports breast cancers of ductal origin occur relatively more frequently in men than in women [3]. In men. an increase in risk of breast cancer has been associated with testicular pathology and dysfunction; and decrease in risk has been related to high fertility, a history of prostate cancer and exogenous androgens. Beyond these observations it can be suggested that risk may be enhanced by low levels and decreased by high levels of androgens. Obesity, rapid weight gain, gallstones and all other conditions known to cause hyperestrogenism in men may enhance also the risk of breast cancer [3].In our patient we could not find any condition that might be a cause of hyperestrogenism. The hormone profiles were within the norm and he did not have a history of breast cancer in his relatives.Nahide Onsun ^-', Ulviye Atilganoglu ", Yasemin B. Rural ",