2022
DOI: 10.1177/2050313x221117884
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Sweet syndrome following Moderna COVID-19 vaccine: A case report

Abstract: With the COVID-19 pandemic, vaccines have been administered all around the world probably more than ever. Even though they are considered safe, with such a huge quantity of doses used, many adverse effects including cutaneous ones were reported. We report here the case of a male adult with a history of monoclonal gammopathy of undetermined significance who presented with an extensive cutaneous eruption of indurated erythematous papules and plaques 2 days after receiving his first dose of Moderna COVID-19 vacci… Show more

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Cited by 4 publications
(5 citation statements)
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“…Additionally, there has been one case of a recurrence of Sweet syndrome after receiving the Moderna mRNA vaccine. 9 Our case is unique in that, to the best of our knowledge, this is the first instance of Sweet syndrome recurrence in response to a patient receiving a booster SARS-CoV-2 Pfizer-BioNTech mRNA vaccine. The patient had previously been administered two doses of the same vaccine formulation without any signs of reemergence.…”
Section: Discussionmentioning
confidence: 80%
“…Additionally, there has been one case of a recurrence of Sweet syndrome after receiving the Moderna mRNA vaccine. 9 Our case is unique in that, to the best of our knowledge, this is the first instance of Sweet syndrome recurrence in response to a patient receiving a booster SARS-CoV-2 Pfizer-BioNTech mRNA vaccine. The patient had previously been administered two doses of the same vaccine formulation without any signs of reemergence.…”
Section: Discussionmentioning
confidence: 80%
“…This patient experienced an identical skin reaction within 24 hours of a second dose of the Moderna mRNA-1273 vaccine, despite being on low dose oral corticosteroids at the time. No reaction was observed following a third vaccination, while still on steroids 6…”
Section: Discussionmentioning
confidence: 90%
“…Cases of vaccine-induced Sweet syndrome have been reported after influenza4 and pneumococcal5 vaccination. There are reports of Sweet syndrome following the Moderna mRNA-1273, Pfizer/BioNTech BNT162b2 and Janssen Ad26.COV2.S vaccines 6–8. There are only four other reported cases of confirmed Sweet syndrome after the ChAdOx1-S vaccine9–12 with an average time to onset of symptoms of 8 days.…”
Section: Discussionmentioning
confidence: 99%
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“… High-dose local corticosteroid treatment. 10 days Recovery Frederic Pelchat et al 42 60 M Multiple, tender, indurated erythematous papules and plaques over his face, trunk, upper, and lower limbs.Mild malaise and fatigue Neutrophilia at 8310 × 10 9 /L, elevated ESR at 15 mm/h. Superficial and middermal histiocytoid cells infiltration with a few accompanying T lymphocytes Systemic steroid therapy Unknown Recovery Maria Efenesia Baffa et al 43 52 M Scattered plaques which show overwhelming vesicles and pustules, or target-like appearance due to a central hemorrhagic crust Unknown A dense and diffuse mixed inflammatory infiltration with a predominance of neutrophils, with subtle perivascular nuclear dust, dilatated capillaries, and prominent edema of the upper dermis Methylprednisolone intravenously 3 weeks Recovery Imran Majid et al 44 65 F Dark red, symmetrical, unclear boundary, rising surface temperature, tender-touched plaques leukocytosis (14,000/mm 3 , 82% of total leukocyte count),ESR(60 mm in 1 h), highly positive CRP.…”
Section: Resultsmentioning
confidence: 99%