Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

Zhou, Chunming; Huang, Song; Liu, Jiang‐Qi; Qiu, Shuqi; Xie, Fang; Hou-pan, Song; Li, Yisheng; Hou, Shaozhen; Lai, Xiaoping

doi:10.1016/j.jep.2012.09.057

Cited by 47 publications

(38 citation statements)

References 53 publications

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“…Thus, high calorie diet-induced obese rats tend to be an exceptional animal model to study molecular mechanisms for the development of obesity and insulin resistance. Cai-Jie et al in their studies showed that feeding of HCD for a period of 12 weeks presented hyperglycemia, increased levels of plasma glucose, insulin and insulin resistance [21]. It is evident that longstanding exposure of animals to fed state leads to insulin resistance syndrome as was characterized by the amplified body weight, mild hyperglycemia and/or glucose intolerance, hypertriglyceridaemia.…”

Section: Discussionmentioning

confidence: 99%

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Padmaja¹,

Naidu²,

Kumar³

et al. 2014

ABB

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Obesity is well recognized as a global public health concern and the quest continues to explore natural product-based novel therapeutics. Bauhinia purpurea finds its place in traditional medicine as an effective anti-ulcer, antiplatelet, wound healing and hypolipidemic agent. The present study investigated the effects of ethanolic extract of Bauhinia purpurea (EEB) on the changes in body weight, lean mass, fat free mass, fat percent, tissue and plasma lipid profiles, plasma glucose, insulin and insulin resistance as well as on the activity of amylase, lipase, leptin and adiponectin levels in high caloric diet (HCD) induced obese rats. After induction of obesity with HCD, rats were administered orally with EEB (100, 200 and 300 mg•kg −1 BW) or orlistat (5 mg•kg −1 BW) once daily for 42 days. HCD substantially increased the body weight, fat free mass, fat percent, glucose, insulin resistance, tissue and plasma lipid profiles (Except HDL), leptin and the activities of amylase and lipase. EEB at a dose of 300 mg•kg −1 BW exerted its therapeutic effects similar to orlistat in decreasing body weight, insulin resistance, levels of glucose, leptin, plasma and tissue lipids, lipase and amylase but increasing HDL and adiponectin in HCD fed obese rats, which could be due to bioactive factors present in EEB, as revealed by LC-MS analysis. These findings suggest that EEB administration suppresses high-caloric-diet-induced obesity and it can be developed as a potential candidate for the treatment of obesity and associated complications.

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Section: Discussionmentioning

confidence: 99%

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Padmaja¹,

Naidu²,

Kumar³

et al. 2014

ABB

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“…Several other treatments were reported to reduce ER stress-induced leptin resistance: a sweet tea leaf extract demonstrated to have an antihyperlipidemic activity, reducing oxidative stress [181]; IL-6 and IL-10 combined with exercise are able to inhibit IKKβ/NFκB pathway [182]; and the low molecular weight, fucoidan, an activator of AMPK, that is used for metabolic disorders and obesity [183]. Very recently, it has been reported that the non-steroidal anti-inflammatory drug, flurbiprofen, reduces ER stress and attenuates leptin resistance, inducing weight loss in obese mice [184].…”

Section: Reduction Of Er Stressmentioning

confidence: 99%

“…Improvement of insulin signaling and glucose homeostasis. Increase in STAT3 phosphorylation [177][178][179][181][182][183][184].…”

Section: Reduction Of Er Stressmentioning

confidence: 99%

Drug targeting of leptin resistance

2015

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“…117 (77) 15 (10) 20 (13) 109 (72) 19 (13) 24 (16) 98 (64) 20 (13) 34 (22) 64 (42) 39 (26) 49 ( 124 (19) 124 (19) 418 (64) 111 (17) 120 (18) 417 (64) 103 (16) 129 (20) 213 (33) 168 (26) 268 ( 138 (16) 157 (18) 551 (64) 150 (17) 163 (19) 310 (36) 227 (26) 327 (38) All records are presented as 'actual number (percentage of the related subgroup)'. 68 (82) means 68 cases, which accounts for 82% of its subgroup.…”

Section: Resultsmentioning

confidence: 99%

“…To Chinese, the three most widely consumed tea are black tea (or the British tea) (fully fermented), oolong tea (semi-fermented) and green tea (non-fermented). 12 The tea extracts have been identified to have pharmacological effects highly associated with reducing blood pressure, 13,14 obesity, 15,16 hyperglycemia 17 and so on. There are clinical studies indicating that tea consumption could lower blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Correlation between tea consumption and prevalence of hypertension among Singaporean Chinese residents aged ⩾40 years

Yang

Zhu

et al. 2015

J Hum Hypertens

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By a cross-sectional epidemiology study, we attempted to correlate the consumption of tea and/or health supplements, living habits and socio-demographic factors to the prevalence of hypertension among Singaporean Chinese residents. Singaporean Chinese residents aged ⩾40 years were randomly selected and interviewed face-to-face by clinical research assistants. Hypertension was defined as measured systolic blood pressure at least 140 mm Hg and/or diastolic blood pressure at least 90 mmHg or self-reported history/treatment for hypertension. The prevalence of hypertension among the whole investigated population (N=1184, 58.27% females) was 49.73% and the prevalence increased to 66.47% in the sub-population aged ⩾60 years. High risk of hypertension was associated with age ⩾60 years (odds ratio (OR): 4.15-4.19, P<0.01), obesity (body mass index >25 kg m(-2), OR: 2.10-2.11, P<0.01), family history of hypertension (OR: 2.69-2.76, P<0.01), diabetes history (OR: 2.29-2.33, P<0.01), hyperlipidemia history (OR: 1.79-1.80, P<0.01), male (OR: 1.56-1.59, P<0.01) and coffee intake (OR: 1.44-1.46, P<0.05). In contrast, drinking green tea at least 150 ml per week was associated with lower hypertension risk (OR: 0.63, 95% confidence interval (CI): 0.43-0.91, P<0.05). Drinking combination of green tea and British tea was associated with higher reduction in the risk of hypertension (OR: 0.58, 95% CI: 0.39-0.85, P<0.05). This cross-sectional study suggests that consumption of tea, especially green tea and British tea, was associated with lowering the risk of hypertension. On the other hand, consumption of coffee could be a risk factor of hypertension. These findings may provide useful information for health promotion to reduce risk of hypertension and warrant further study to confirm and elucidate such association.

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Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

Cited by 47 publications

References 53 publications

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Drug targeting of leptin resistance

Correlation between tea consumption and prevalence of hypertension among Singaporean Chinese residents aged ⩾40 years

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Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

Cited by 47 publications

References 53 publications

Antiobesity Activity of &lt;i&gt;Bauhinia purpurea&lt;/i&gt; Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antiobesity Activity of &lt;i&gt;Bauhinia purpurea&lt;/i&gt; Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Drug targeting of leptin resistance

Correlation between tea consumption and prevalence of hypertension among Singaporean Chinese residents aged ⩾40 years

Contact Info

Product

Resources

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Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats

Antiobesity Activity of <i>Bauhinia purpurea</i> Extract: Effect on Hormones and Lipid Profile in High Calorie Diet Induced Obese Rats