Swelling and Mechanical Properties of Modified HEMA-based Superporous Hydrogels

Omidian, Hossein; Park, Kinam; Kandalam, Umadevi; Rocca, Jose G.

doi:10.1177/0883911510375175

Cited by 50 publications

(36 citation statements)

References 34 publications

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“…These porous scaffolds can be easily processed from CS with no external crosslinking agent, taking advantage of the polysaccharide properties. Depending on the pore sizes, porous hydrogels are classified as nanoporous (pores size below 10 nm), microporous (pore sizes in the range 10 nm–10 µm) and macroporous or superporous (pores size above 10 µm) …”

Section: Hydrogels Prepared Directly From Native Csmentioning

confidence: 99%

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Racine

Texier

Auzély‐Velty

2017

Polymer International

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Chitosan (CS) has received much attention as a functional biopolymer for designing various hydrogels for biomedical applications. This review provides an overview of the different types of CS-based hydrogels, the approaches that can be used to fabricate hydrogel matrices with specific features and their applications in controlled drug delivery and tissue engineering. Emphasis is laid on the recent design concepts of hybrid hydrogels based on mixtures of CS and natural or synthetic polymers, interpenetrating polymer networks as well as composite hydrogels prepared by embedding nanoparticles into CS matrices.

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Section: Hydrogels Prepared Directly From Native Csmentioning

confidence: 99%

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Racine

Texier

Auzély‐Velty

2017

Polymer International

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“…Furthermore, the release of a drug through a network gel based on P(HEMA) is strongly affected by the water swelling capacity [27], and responsivity to the external conditions is of special importance for controlled release systems. HEMA is considered a nonionic monomer and, to get pH responsive behavior, it generally has been copolymerized with ionic monomers [32, 33], or P(HEMA) gels has been hydrolyzed with alkaline at high temperatures [34]. In literature, Ferreira et al [27] prepared P(HEMA) hydrogels by using tripropyleneglycol diacrylate crosslinker with wide range concentrations and stated that swelling capacity increased at alkaline pH values.…”

Section: Introductionmentioning

confidence: 99%

Poly(2‐hydroxyethyl methacrylate) nanocomposites: From a nonionic gel to pH sensitivity

Cavusoglu

Kaşgöz

2011

Polymer Composites

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2‐Hydroxyethyl methacrylate (HEMA)‐clay nanocomposites were prepared via in situ free radical polymerization using montmorillonite (MMT) as a crosslinker. The structure and surface morphology of the nanocomposites were characterized by Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction, and scanning electron microscopy. It was found that exfoliated or highly expanded intercalated nanocomposite structure was obtained. The swelling degree was determined in distilled water and various pH buffered solutions. The highest swelling capacity in distilled water was observed for the nanocomposite sample prepared with the MMT amount of 10 % (w). It was seen that the diffusion mechanism was Fickian type in distilled water and also in various pH‐buffered solutions. It is interesting that the swelling degree of nanocomposites in alkaline pH values increased by the increasing of MMT in the polymer structure. This result supports the possibility of future applications of the novel nanocomposite in systems for the controlled released of drugs. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers

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“…Swelling coefficients for PFMA and PGMA hydrogels decrease with increasing crosslinking density, as expected. Moreover, swelling coefficient decreases significantly in the buffered medium, compared with deionized water, probably due to ionic strength, as reported for poly(2‐hydroxyethyl methacrylate) hydrogels . The knowledge of the swelling behavior of hydrogels in electrolyte solution is of great importance because hydrogels are mainly used in biomedical applications.…”

Section: Resultsmentioning

confidence: 85%

Macroporous hydrogels based on carbohydrates monomethacrylates and dimethacrylates: singular properties from carbohydrate‐based crosslinkers

Perin

Fonseca

Felisberti

2019

J of Chemical Tech & Biotech

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BACKGROUND Readily available feedstock and biocompatibility make carbohydrate‐based hydrogels promising materials for biomedical applications. However, carbohydrate‐based crosslinkers are rather underexplored when compared with crosslinkers derived from fossil resources. In this study, novel fully bio‐based hydrogels derived from enzymatically produced d‐fructose and d‐glucose methacrylate monomers were synthesized with different amounts of d‐fructose dimethacrylate crosslinker. RESULTS The use of a carbohydrate‐based crosslinker endows hydrogels with high swelling coefficients, up to 2400%, and superior mechanical resistance (compressive modulus up to 9.5 kPa with a maximum stress up to 50 kPa) compared with conventional crosslinkers based on fossil resources. Hydrogels shape and crosslinking density influences hydrogel morphology, swelling behavior and mechanical resistance. Moreover, hydrogels presented cell viability, biodegradability and hydrolysis‐resistance over a wide range of pH. CONCLUSION The use of a highly hydrophilic crosslinker based on carbohydrate for hydrogels synthesis enables the use of high crosslinker concentration, which improves mechanical properties, however with minor loss of the water swelling capacity, compared with conventional fossil‐based crosslinkers. This is an important advantage over conventional crosslinkers based on fossil resources. Moreover, slab hydrogels hold higher stress under compression–decompression cycles, and present higher resistance to hydrolysis in basic medium due to the thicker pore walls than cylindrical ones. © 2019 Society of Chemical Industry

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Swelling and Mechanical Properties of Modified HEMA-based Superporous Hydrogels

Cited by 50 publications

References 34 publications

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Chitosan‐based hydrogels: recent design concepts to tailor properties and functions

Poly(2‐hydroxyethyl methacrylate) nanocomposites: From a nonionic gel to pH sensitivity

Macroporous hydrogels based on carbohydrates monomethacrylates and dimethacrylates: singular properties from carbohydrate‐based crosslinkers

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