Swelling behaviour and elastic properties of gelatin gels

Yang, Xian; Zheng, Pei Jie; Cui, Zhenduo; Zhao, Na; Wang, Yu Fen; Yao, Kang

doi:10.1002/(sici)1097-0126(199712)44:4<448::aid-pi845>3.0.co;2-m

Cited by 51 publications

(36 citation statements)

References 2 publications

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“…The process implies the breaking of collagen's triple-helix structure into random coils. Gelatin exhibits excellent biocompatibility, plasticity and adhesiveness [2], and it is a good film and particle-forming material [3]. Moreover, it forms a thermoreversible gel with a melting point close to body temperature, which is particularly significant in edible and pharmaceutical applications [4].…”

Section: Introductionmentioning

confidence: 68%

Chemico-physical characterization of gelatin films modified with oxidized alginate

et al. 2010

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Section: Introductionmentioning

confidence: 68%

Chemico-physical characterization of gelatin films modified with oxidized alginate

et al. 2010

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“…Above pI, the network is negatively charged forming an anionic gel as shown in equation (1) and (2). The swelling degree is unsymmetric with respect to the isoelectric point, hydrogels containing net positive charges swell to a greater extent than those carrying net negative [13][14]. From Figure 1., we can clearly see that the swelling behavior of gelatin / CNC hydrogel below pI, which is at pH 3 that show the highest swelling ratio.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of chemical cross-linked gelatin hydrogel reinforced with cellulose nanocrystals (CNC)

Yin

Ahmad

Amin

2014

AIP Conference Proceedings

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“…The greater relative ionic strength of phosphate buffer (as a dissolution medium) reportedly prolongs the swelling behaviour and disintegration time (in-vitro rupture time) of HGCs considerably, which could be related to the degree of ionization of the solution; this phenomenon has been attributed to the formation of ion pairs between network charges and counterions 30 . The authors studied the swelling behaviour of gelatin using solutions with different NaCl concentrations.…”

Section: Effects Of Dissolution Medium and γ-Radiation Dose On Hgc Inmentioning

confidence: 99%

Adaptation of Hard Gelatin Capsules for Aqueous Solution Delivery Using Gamma Radiation

Omar

Abdel-Rashid

Assaly³

et al. 2018

Journal of Advanced Pharmacy Research

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Objective: Directly incorporating aqueous solutions into hard gelatin capsules (HGCs) without dispersing them in an oily medium is considered a challenge for most researchers and manufacturers. The aim of the study is to evaluate the effect of gamma radiation (ɣ-radiation) on the adaptation of HGCs for aqueous solution delivery. Methods: Empty HGC shells were exposed to four of ɣ-radiation doses (1, 3, 5, 10 kGy). Then, the physicochemical properties of irradiated capsules were evaluation and compared with those of non-irradiated capsules. Fourier-transform infrared spectroscopy (FT-IR), capsule hardness, and water incorporation tests were performed. In-vitro disintegration/dissolution behavior determined as (rupture time) in different dissolution media was evaluated. Results: The results showed direct proportionality between the ɣ-radiation dose and HGC crosslinking degree up to 3 kGy, while at doses >3 kGy, degradation rather than crosslinking occurred. The results were clearly demonstrated by FTIR as peptide linkages between gelatin molecules. All the ɣ-irradiated HGCs submitted to hardness test were completely deformed without rupture with increasing capsule deformation work (J) for γ-radiation doses up to 3 kGy; the deformation work declined at doses >3 kGy. The water incorporation study revealed that capsules exposed to 3 kGy could hold up to 100 ml of methylene blue solution without deformation or leakage for 45 minutes compared with non-irradiated HGCs, which showed a significantly lower tolerance of only 2 minutes (p<0.001). The crosslinking of HGCs had a minor significant effect on in-vitro rupture time, especially at gastric pH. Conclusion: The irradiation technique may be used not only for sterilizing HGCs but also for adapting HGCs for aqueous solutions delivery, as it showed a significant positive effect, which was optimal at a dose of 3 kGy. However, these results are not sufficient for scaled-up manufacturing; thus, further investigations are strongly recommended.

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Swelling behaviour and elastic properties of gelatin gels

Cited by 51 publications

References 2 publications

Chemico-physical characterization of gelatin films modified with oxidized alginate

Chemico-physical characterization of gelatin films modified with oxidized alginate

Synthesis of chemical cross-linked gelatin hydrogel reinforced with cellulose nanocrystals (CNC)

Adaptation of Hard Gelatin Capsules for Aqueous Solution Delivery Using Gamma Radiation

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