Swept-Source Optical Coherence Tomography Angiography of Paediatric Macular Diseases

Stanga, Paulo E; Papayannis, Alessandro; Tsamis, Emmanouil; Chwiejczak, Katarzyna; Stringa, Francesco; Jalil, Assad; Cole, Tim; Biswas, Susmito

doi:10.1159/000442809

Cited by 35 publications

(27 citation statements)

References 17 publications

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“…Stanga et al 34 have described the same petaloid pattern inside of the deep vascular plexus and perifoveal microvascular changes on OCT-A. They also reported areas of hypo-and hyper-reflectivity at the level of choriocapillaris that were not associated with any other vascular disorder but might be attributed to alterations in OCT-A signal due to RPE irregularities.…”

Section: Discussionmentioning

confidence: 79%

Swept-source and optical coherence tomography angiography in patients with X-linked retinoschisis

Padrón-Pérez

Català‐Mora

Díaz

et al. 2018

Eye

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PurposeTo explore the structural features of juvenile X-linked retinoschisis (XLRS) using swept-source-optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A).DesignRetrospective, observational cross-sectional study.Patients and methodsNine patients (18 eyes) diagnosed with juvenile XLRS were included. SS-OCT and OCT-A were used to evaluate the characteristics of the inner/outer retina and the choroid.ResultsSS-OCT showed that the inner nuclear layer (INL) was the most commonly affected area (16/18 eyes; 89%). No significant differences in central macular thickness (CMT) or subfield choroidal thickness (SFCT) were evidenced between eyes (CMT: 364 μm in the right eye vs 320 μm in the left eye; SFCT: 305 vs 307 μm; P=0.895). Best-corrected visual acuity (BCVA) did not correlate with CMT (rs= -0.19; P=0.445) or SFCT (rs=0.06; P=0.795). BCVA was significantly correlated with the following defects: outer plexiform layer (OPL; rs=0.50; P=0.036); external limiting membrane (ELM; rs=0.65; P=0.003); ellipsoid portion of inner segment (EPIS; rs=0.67; P=0.002); and the cone outer segment tips (COST; rs=0.69; P=0.001). Schisis at the INL revealed a spoke-like pattern in the foveal region and a reticular pattern in the parafoveal region on en-face imaging. In cases in which the schisis affected the OPL, multiple polygonal hyporeflective cavities were observed in the foveal region.ConclusionsThe hyporeflective spaces on SS-OCT were primarily located at the INL and OPL. BCVA did not correlate with CMT or SFCT; however, ELM, EPIS, and COST defects were significantly correlated with worse BCVA. There was a positive correlation between age and SFCT.

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Section: Discussionmentioning

confidence: 79%

Swept-source and optical coherence tomography angiography in patients with X-linked retinoschisis

Padrón-Pérez

Català‐Mora

Díaz

et al. 2018

Eye

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“…Our study does not confirm the findings. To the best of our knowledge, only Stanga et al described OCT angiography in typically pediatric diseases, such as X-linked retinoschisis, Best disease, and Coats' disease [15]. As far as we know, the present study is the first which investigates usefulness of both OCT and OCTA in monitoring Coats' disease in children.…”

Section: Discussionmentioning

confidence: 88%

“…This new technique is useful in the diagnosis of different retinal vascular diseases, such as diabetic retinopathy, retinal vein occlusion, or age-related macular degeneration [12–14]. OCTA seems to be a promising method also in the diagnostics of pediatric patients, for whom fluorescein angiography, as an invasive method, is particularly stressful [15]. The aim of the present study was to evaluate if OCTA can offer additional information about vascular disorders related to Coats' disease and to assess this method in diagnostics and monitoring children affected by Coats' disease.…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Monitoring Coats’ Disease

Hautz

Gołębiewska

Kocyła-Karczmarewicz

2017

Journal of Ophthalmology

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Purpose. The aim of this study was to evaluate the usefulness of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in monitoring pediatric patients with Coats' disease. Material and Methods. This retrospective study included 9 Caucasian patients receiving treatment for Coats' disease at the Children's Memorial Health Institute Ophthalmology Department between December 2014 and May 2016. The course of the disease was monitored with OCTA in combination with OCT and fluorescein angiography (FA). Results. OCT B-scans obtained in all patients correlated with FA findings. Reliable OCTA images were obtained in 8 patients. In one patient, numerous artifacts due to poor visual acuity and retinal detachment confounded the interpretation of findings. Conclusions. OCTA and OCT, in combination with FA, are useful in Coats' disease diagnostics and treatment monitoring. As noninvasive methods, OCT and OCTA may be performed more often than FA, which enable precise monitoring of the disease and making decisions as to its further treatment.

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“…OCT-A has been used in the study of other pediatric retinal pathologies including X-linked retinoschisis (XLRS) [78,98,99], an X-linked recessive disorder that occurs almost exclusively in young males and that entails an early-onset bilateral visual loss due to foveal schisis. In these studies, a reduced macular deep vessel density was seen.…”

Section: Applications Of Oct-a In Other Pediatric Retinopathiesmentioning

confidence: 99%

OCT Angiography: A Technique for the Assessment of Retinal and Optic Nerve Diseases in the Pediatric Population

et al. 2018

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Optical coherence tomography angiography (OCT-A) is a novel, rapidly evolving, non-invasive imaging technique that allows images of the retinal vasculature to be obtained in a few seconds. Blood vessels of different retinal vascular plexuses and the foveal avascular zone (FAZ) can be examined without the administration of any contrast or dye. Due to these characteristics, OCT-A could be an excellent complementary test to study retinal vascularization in children. Until now, most of the studies with OCT-A have been conducted in adults and only a few have been carried out in children. In this review, we describe the principles and advantages of OCT-A over traditional imaging methods and provide a summary of the OCT-A findings in retinopathy of prematurity and other retinal and optic disc pathologies in children. In view of the promising results from studies, the advantages of a relatively rapid and non-invasive method to assess the retinal vasculature makes OCT-A a tool of which applications in the field of pediatric ophthalmology will be expanded in the near future for patient diagnosis and follow-up in every day clinical practice.

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Swept-Source Optical Coherence Tomography Angiography of Paediatric Macular Diseases

Cited by 35 publications

References 17 publications

Swept-source and optical coherence tomography angiography in patients with X-linked retinoschisis

Swept-source and optical coherence tomography angiography in patients with X-linked retinoschisis

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Monitoring Coats’ Disease

OCT Angiography: A Technique for the Assessment of Retinal and Optic Nerve Diseases in the Pediatric Population

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