Swim training restores glucagon-like peptide-1 insulinotropic action in pancreatic islets from monosodium glutamate-obese rats

Svidnicki, Paulo Vinícius; Leite, Nayara C.; Venturelli, Amanda Caroline; Camargo, Rafael Ludemann; Vicari, Marcelo Ricardo; Almeida, Mara Cristina de; Artoni, Roberto Ferreira; Nogaroto, Viviane; Grassiolli, Sabrina

doi:10.1111/apha.12128

Cited by 20 publications

(11 citation statements)

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“…For example, in everyone with type 2 diabetes, fasting plasma ghrelin levels are typically reduced and decrease less in reactions to a meal [ 1 – 3 ]. Fasting and postprandial PP and PYY levels are lower in obese individuals [ 4 , 5 ], and individuals with type 2 diabetes have been displayed to have diminished postprandial fullness [ 3 ]. These undesirable modifications in appetite and satiety control are not permanent, as a short-time session of aerobic exercise has been shown to enhance postprandial fullness in everyone with type 2 diabetes, with no changing acylated ghrelin levels [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight

Afrasyabi

Marandi

Kargarfard

2019

J Diabetes Metab Disord

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Background and purpose The connection between exercise and appetite has ramifications for acute energy balance and weight-management. Research would suggest that exercise training can transiently suppress appetite, particularly in overweight and T2D, healthy-weight individuals. However, the effect of such a transient appetite suppression on subsequent food intake may be restricted. The aim of this thesis was to investigate appetite responses to HIIT in obesity with T2D and to assess the effect of other exercise characteristics, as well as exercise intensity, in mediating these responses especially appetite hormones. Materials and methods Eighty individuals with type 2 diabetes (forty normal and forty obesity weight) performed HIIT trials, all in arandomly divided, in 8 groups (10 in each group) which included, obesity non-diabetic control, obesity diabetic control, normal weight diabetic control, obesity non-diabetic training, obesity diabetic training, normal weight, non-diabetic training, and normal weight diabetic training. Twelve-weeks HIIT sessions (each session of an interval training includes 60 s of high intensity training (85–95% of reserve heart rate)) + running for 60 s at low intensity (55–60% of reserve heart rate) were applied. Blood samples were taken at the beginning and after the fourth, eighth and twelfth week of the training. Data were analyzed using repeated variance analysis and Pearson correlation coefficient. Results The results showed that training reduced ghrelin plasma levels in obese diabetic subjects ( P < 0.05). Training has reduced PYY plasma in healthy subjects (non-diabetic) with normal weight (P < 0.05). Training reduced plasma levels of PYY in diabetic patients with normal weight and increased it in obese diabetic and healthy subjects ( P < 0.05). Training has increased GLP-1 plasma in obese diabetic and diabetic with normal weight groups ( P < 0.05). Training reduced TNF-α in normal (non-diabetic) subjects with normal weight and diabetic and non-diabetic obese subjects. Conclusion Collectively, the studies reported here suggest that appetite hormones differ between lean and obesity participants. The finding also suggested HIIT is more likely to elicit appetite hormones responses in obesity than in lean individuals with type 2 diabetes. Therefore, with caution, it is recommended that the high intensity interval training can be beneficial for these patients.

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Section: Introductionmentioning

confidence: 99%

The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight

Afrasyabi

Marandi

Kargarfard

2019

J Diabetes Metab Disord

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“…, Svidnicki et al . ). Furthermore, physical inactivity has a negative effect on vascular function (Nyberg et al .…”

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confidence: 97%

Leucocyte telomere length as marker for cardiovascular ageing

Zietzer

Hillmeister

2014

Acta Physiologica

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“…Interestingly, present studies on epigenetics accumulate evidence that physical activity influences DNA methylation and histone modifications resulting in a direct impact on genes involved in metabolism, muscle growth and inflammation (Svidnicki et al . , Sebert et al . , Yuan et al .…”

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confidence: 99%

“…In adipose tissue, the induction of genes involved in oxidative phosphorylation appears to be one mechanism for the beneficial effect of exercise (R€ onn et al 2014). Interestingly, present studies on epigenetics accumulate evidence that physical activity influences DNA methylation and histone modifications resulting in a direct impact on genes involved in metabolism, muscle growth and inflammation (Svidnicki et al 2013, Sebert et al 2014, Yuan et al 2014. Physical activity further provokes reduced blood pressure and beneficially altered autonomic tone as found in hypertensive individuals (Edwards et al 2011).…”

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confidence: 99%

High expectations: from treatment to prevention

Ludwig

Högner

2015

Acta Physiologica

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Swim training restores glucagon-like peptide-1 insulinotropic action in pancreatic islets from monosodium glutamate-obese rats

Abstract: Exercise avoids insulin hypersecretion restoring GLP-1's insulinotropic action in pancreatic islets from MSG-obese rats.

Cited by 20 publications

References 47 publications

The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight

The effects of high intensity interval training on appetite management in individuals with type 2 diabetes: influenced by participants weight

Leucocyte telomere length as marker for cardiovascular ageing

High expectations: from treatment to prevention

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