Swimming does not alter nociception threshold in obese rats submitted to median nerve compression

Coradini, Josinéia Gresele; Kunz, Regina Inês; Kakihata, Camila Mayumi Martin; Errero, Tatiane Kamada; Bonfleur, Maria Lúcia; Ribeiro, Lucinéia de Fátima Chasko; Brancalhão, Rose Meire Costa; Bertolini, Gladson Ricardo Flor

doi:10.1080/01616412.2015.1114742

Cited by 5 publications

(14 citation statements)

References 28 publications

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“…Actually, obese prediabetic mice showed higher levels of GDNF and NGF in nerves and spinal cord [695]. In contrast, swimming does not alter nociception threshold in obese rats submitted to median nerve compression [696]. Regarding human studies, it has been suggested that increased physical exercise has no mitigating effects on low back pain in obese subjects [49], but further studies on the beneficial effects of physical exercise are needed to obtain robust conclusions on pain modulation on obese subjects.…”

Section: Pathological Pain: Relationship With Sedentary Behavior and ...mentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).

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Section: Pathological Pain: Relationship With Sedentary Behavior and ...mentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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“…The studies included rats (26 studies) [ 21 – 29 , 32 – 38 , 40 – 42 , 45 – 47 , 51 , 52 , 56 , 58 ], mice (13 studies) [ 20 , 30 , 31 , 39 , 44 , 48 – 50 , 53 – 55 , 57 , 59 ] or rabbits (1 study) [ 43 ]. Sprague Dawley rats (18 studies) [ 21 , 24 – 29 , 32 , 35 – 38 , 40 , 42 , 47 , 51 , 52 , 56 ], C57BL/6J mice (8 studies) [ 20 , 30 , 31 , 39 , 48 , 53 , 57 , 59 ] and Wistar rats (7 studies) [ 22 , 23 , 33 , 34 , 41 , 45 , 58 ] were the most frequently used animal strains. Thirty studies exclusively used male animals [ 20 , 23 , 25 , 28 – 31 , 33 – 39 , 41 – 50 , 52 , 54 – 56 , 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

The effects of aerobic exercise on neuroimmune responses in animals with traumatic peripheral nerve injury: a systematic review with meta-analyses

Sleijser-Koehorst

Koop

Coppieters

et al. 2023

J Neuroinflammation

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Background Increasing pre-clinical evidence suggests that aerobic exercise positively modulates neuroimmune responses following traumatic nerve injury. However, meta-analyses on neuroimmune outcomes are currently still lacking. This study aimed to synthesize the pre-clinical literature on the effects of aerobic exercise on neuroimmune responses following peripheral nerve injury. Methods MEDLINE (via Pubmed), EMBASE and Web of Science were searched. Controlled experimental studies on the effect of aerobic exercise on neuroimmune responses in animals with a traumatically induced peripheral neuropathy were considered. Study selection, risk of bias assessment and data extraction were performed independently by two reviewers. Results were analyzed using random effects models and reported as standardized mean differences. Outcome measures were reported per anatomical location and per class of neuro-immune substance. Results The literature search resulted in 14,590 records. Forty studies were included, reporting 139 comparisons of neuroimmune responses at various anatomical locations. All studies had an unclear risk of bias. Compared to non-exercised animals, meta-analyses showed the following main differences in exercised animals: (1) in the affected nerve, tumor necrosis factor-α (TNF-α) levels were lower (p = 0.003), while insulin-like growth factor-1 (IGF-1) (p < 0.001) and Growth Associated Protein 43 (GAP43) (p = 0.01) levels were higher; (2) At the dorsal root ganglia, brain-derived neurotrophic factor (BDNF)/BDNF mRNA levels (p = 0.004) and nerve growth factor (NGF)/NGF mRNA (p < 0.05) levels were lower; (3) in the spinal cord, BDNF levels (p = 0.006) were lower; at the dorsal horn, microglia (p < 0.001) and astrocyte (p = 0.005) marker levels were lower; at the ventral horn, astrocyte marker levels (p < 0.001) were higher, and several outcomes related to synaptic stripping were favorably altered; (4) brainstem 5-HT2A receptor levels were higher (p = 0.001); (5) in muscles, BDNF levels (p < 0.001) were higher and TNF-α levels lower (p < 0.05); (6) no significant differences were found for systemic neuroimmune responses in blood or serum. Conclusion This review revealed widespread positive modulatory effects of aerobic exercise on neuroimmune responses following traumatic peripheral nerve injury. These changes are in line with a beneficial influence on pro-inflammatory processes and increased anti-inflammatory responses. Given the small sample sizes and the unclear risk of bias of the studies, results should be interpreted with caution.

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“…Other biomarkers, such as neurotrophins and neurotransmitters are also modulated by exercise. Of note, studies which did not demonstrate an effect on biomarkers used exercise duration of less than 40 minutes, 29 , 31 perhaps insufficient time to generate changes. In contrast, studies showing an effect on biomarkers included sessions with a duration between 60 and 90 minutes.…”

Section: Discussionmentioning

confidence: 99%

“… 29 , 30 Only 1 article found no post-treatment differences in BDFN concentrations. 31 One paper found an increase of GAP-43 in the peripheral nerve. 31 …”

Section: Qualitative Analysismentioning

confidence: 99%

Effect of Physiotherapeutic Interventions on Biomarkers of Neuropathic Pain: A Systematic Review of Preclinical Literature

Matesanz-García

Schmid

Cáceres-Pajuelo³

et al. 2022

The Journal of Pain

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Swimming does not alter nociception threshold in obese rats submitted to median nerve compression

Abstract: In conclusion, swimming, a conservative treatment for peripheral nerve lesions, was not able to improve the nociception threshold in obese rats.

Cited by 5 publications

References 28 publications

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

The effects of aerobic exercise on neuroimmune responses in animals with traumatic peripheral nerve injury: a systematic review with meta-analyses

Effect of Physiotherapeutic Interventions on Biomarkers of Neuropathic Pain: A Systematic Review of Preclinical Literature

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