SWITCH 1/DYAD is a novel WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis

Abstract

Mitosis and meiosis both rely on cohesin, which embraces the sister chromatids and plays a crucial role for the faithful distribution of chromosomes to daughter cells. Prior to the cleavage by Separase at anaphase onset, cohesin is largely removed from chromosomes by the nonproteolytic action of WINGS APART-LIKE (WAPL), a mechanism referred to as the prophase pathway. To prevent the premature loss of sister chromatid cohesion, WAPL is inhibited in early mitosis by Sororin. However, Sororin homologs have only been found to function as WAPL inhibitors during mitosis in vertebrates and Drosophila. Here we show that SWITCH 1/DYAD defines a novel WAPL antagonist that acts in meiosis ofArabidopsis. Crucially, SWI1 becomes dispensable for sister chromatid cohesion in the absence of WAPL. Despite the lack of any sequence similarities, we found that SWI1 is regulated and functions in a similar

Association mapping reveals genomic regions associated with bienniality and resistance to biotic stresses in arabica coffee

“…The first gene encodes a DYAD family protein, which plays a role in chromosome pairing (Li et al 2005). In this sense, recent study demonstrate that the SWITCH 1/DYAD gene acts during meiosis in Arabidopsis thaliana (Yang et al 2019). The second candidate gene (LOC113766162), Pru ar 1, belongs to the PR-10 protein family.…”