Switchable Wettability of Thermo‐Responsive Biocompatible Nanofibrous Films Created by Electrospinning

Gu, Shuai; Wang, Zhimei; Li, Jianbo; Ren, Jie

doi:10.1002/mame.200900215

Cited by 70 publications

(53 citation statements)

References 48 publications

(113 reference statements)

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“…[26][27] Previous reports showed that PNIPAAm and poly(L-lactide) (PLLA) mixture with tunable surface morphologies can be increased by spinning from N-N-dimethylformamide (DMF). [28] Ethyl cellulose (EC) is a kind of polysaccharides with a good film-forming ability, hydrophobicity and biocompatibility. Therefore, it is widely used in nanofibers preparation, either blended or coaxial electrospun, for application in drug-release fields.…”

Section: Introductionmentioning

confidence: 99%

Core-Sheath Nanofibers as Drug Delivery System for Thermoresponsive Controlled Release

Pan

Bligh

et al. 2017

Journal of Pharmaceutical Sciences

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(LMZ); a.bligh@westminster.ac.uk (SWAB). AbstractThermoresponsive, polymer-based core-sheath nanofibres are of great interest as advanced materials because they are capable of responding to external stimuli and delivering drugs as part of release strategy. Core-sheath nanofibers were constructed by using thermoresponsive poly-(N-isopropylacrylamide) (PNIPAAm) (as core) and hydrophobic ethylcellulose (EC) (as sheath) by coaxial electrospinning. Analogous medicated nanofibers were prepared by loading with a model drug ketoprofen (KET).The fibers were cylindrical without phase separation and have visible core-sheath structure as shown by scanning and transmission electron microscopy. X-ray diffraction patterns demonstrated the drug with the amorphous physical form was present in the fiber matrix. Fourier transform infrared spectroscopy analysis was conducted, finding that there were significant intermolecular interactions between KET and the polymers. Water contact angle measurements proved that the hydrophilic hydrophobic transformation of core-sheath fibers had taken place when the temperature reached the lower critical solution temperature. In vitro drug-release study of nanofibers with KET displayed that the coaxial nanofibers were able to synergistically combine the characteristics of the two polymers producing a temperature-sensitive drug delivery system with sustained release properties. In addition, they were established to be non-toxic and suitable for cell growth. These findings show that the core-sheath nanofiber is a potential candidate for controlled drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Core-Sheath Nanofibers as Drug Delivery System for Thermoresponsive Controlled Release

Pan

Bligh

et al. 2017

Journal of Pharmaceutical Sciences

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“…The outflowing of polymer solutions with specific viscosity, conductivity, and surface tension through a thin capillary in the presence of an externally applied electric field results in the production of micro-or nanoparticles or fibers of various sizes and shapes. 19,20 Multicompartmental characteristics of the anisotropic architectures make them suitable for a number of intriguing applications, including switchable display devices, 21 a colloidal stabilizer at an interface of two immiscible solutions, 22 selfpropelled motors, 23 optical sensors, 24 and spontaneous assembly for complex structures. 25 In addition, multicompartmental nanofibers with core-shell [26][27][28][29] and side-by-side 30,31 structures have been explored for drug delivery systems and tissue engineering scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems

Jalani

Jung

Lee

et al. 2014

IJN

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Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli.

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“…[62,63] For more complex patterned surfaces or hierarchical structured surfaces, laser treatment and electrospinning methods are usually applied. [64][65][66] Chemical methods can provide more complex structures with precise control in nanoscale. Hydrothermal methods can produce single crystals with precisely shape-controlled nanostructures, while anodization can produce large-area modifications of nanoholes, nanotubes, nanowires, etc.…”

Section: Introduction Of the Fabrication Methods To Generate Slpl Intmentioning

confidence: 99%

Superlyophilic Interfaces and Their Applications

et al. 2017

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Superlyophilic interfaces denote interfaces displaying strong affinity to diverse liquids, including superhydrophilic, superoleophilic, and superamphiphilic interfaces. When coming in contact with these interfaces, water or oil droplets tend to spread completely with contact angles close to 0°, presenting versatile applications including self‐cleaning, antifogging, controllable liquid transport, liquid separation, and so forth. Inspired by nature, scientists have developed various kinds of artificial superlyophilic (SLPL) interfaces in the past decades. In terms of dimensional characteristics, the artificial SLPL interfaces can be divided into four categories: i) 0D particles, whose dispersibility or catalytic performance can be notably enhanced by superlyophilicity; ii) 1D micro‐/nanofibers or nanotubes/channels, which can efficiently transfer liquids with SLPL interfaces; iii) 2D flat SLPL interfaces, on which different functional molecules can be deposited uniformly, forming ultrathin and smooth films; and iv) 3D structures, which can be obtained by either constructing 0D, 1D, or 2D SLPL materials separately or directly fabricating random SLPL frameworks, and can always be used as functional coatings or bulk materials. Here, natural and artificial SLPL interfaces are briefly introduced, followed by a short discussion of the limit between lyophilicity and lyophobicity, and then a snapshot of methods to generate SLPL interfaces is given. Specific focus is placed on recent achievements of constructing SLPL interfaces from zero to three dimensions. Following that, broad applications of SLPL interfaces in commercial areas will be introduced. Finally, a short summary and outlook for future challenges in this field is presented.

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Switchable Wettability of Thermo‐Responsive Biocompatible Nanofibrous Films Created by Electrospinning

Cited by 70 publications

References 48 publications

Core-Sheath Nanofibers as Drug Delivery System for Thermoresponsive Controlled Release

Core-Sheath Nanofibers as Drug Delivery System for Thermoresponsive Controlled Release

Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems

Superlyophilic Interfaces and Their Applications

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