Symbiotic Photosynthetic Oxygenation within 3D-Bioprinted Vascularized Tissues

Maharjan, Sushila; Alva, Jacqueline; Cámara, Cassandra; Rubio, Andrés G.; Hernández, D.; Delavaux, Clément; Correa, Erandy; Romo, Mariana D.; Bonilla, Diana; Santiago, Mille Luis; Li, Wanlu; Cheng, Feng; Ying, Guoliang; Zhang, Yu Shrike

doi:10.1016/j.matt.2020.10.022

Cited by 79 publications

(66 citation statements)

References 65 publications

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“…Direct 3D printing of alginate hydrogel scaffolds largely followed a method previously reported with minor modifications. [ 49,50 ] The STL files of the digital models were fed into a 3D printer (Allevi 1) for creating the desired patterns. Following printing, the alginate scaffolds were immediately physically crosslinked in a cold CaCl 2 bath (2.5%) for 10 min, and then stored in water at 4 °C until use.…”

Section: Methodsmentioning

confidence: 99%

Freeze‐Casting with 3D‐Printed Templates Creates Anisotropic Microchannels and Patterned Macrochannels within Biomimetic Nanofiber Aerogels for Rapid Cellular Infiltration

John

McCarthy

Wang

et al. 2021

Adv Healthcare Materials

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A new approach is described for fabricating 3D poly(ε‐caprolactone) (PCL)/gelatin (1:1) nanofiber aerogels with patterned macrochannels and anisotropic microchannels by freeze‐casting with 3D‐printed sacrificial templates. Single layer or multiple layers of macrochannels are formed through an inverse replica of 3D‐printed templates. Aligned microchannels formed by partially anisotropic freezing act as interconnected pores between templated macrochannels. The resulting macro‐/microchannels within nanofiber aerogels significantly increase preosteoblast infiltration in vitro. The conjugation of vascular endothelial growth factor (VEGF)‐mimicking QK peptide to PCL/gelatin/gelatin methacryloyl (1:0.5:0.5) nanofiber aerogels with patterned macrochannels promotes the formation of a microvascular network of seeded human microvascular endothelial cells. Moreover, nanofiber aerogels with patterned macrochannels and anisotropic microchannels show significantly enhanced cellular infiltration rates and host tissue integration compared to aerogels without macrochannels following subcutaneous implantation in rats. Taken together, this novel class of nanofiber aerogels holds great potential in biomedical applications including tissue repair and regeneration, wound healing, and 3D tissue/disease modeling.

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Section: Methodsmentioning

confidence: 99%

Freeze‐Casting with 3D‐Printed Templates Creates Anisotropic Microchannels and Patterned Macrochannels within Biomimetic Nanofiber Aerogels for Rapid Cellular Infiltration

John

McCarthy

Wang

et al. 2021

Adv Healthcare Materials

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“…Microalgae[ 143 , 144 ] have also had representation within the bioprinting literature. Recent experimental evidence shows that the symbiotic coexistence of microalgae and mammalian cells in thick bioprinted tissue constructs is a feasible alternative for enabling a sustainable supply of oxygen within the constructs.…”

Section: Bioinks For Different Bioprinting Technologiesmentioning

confidence: 99%

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Pedroza-González¹,

Rodríguez-Salvador²,

Pérez-Benítez³

et al. 2024

IJB

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This scientometric analysis of 393 original papers published from January 2000 to June 2019 describes the development and use of bioinks for 3D bioprinting. The main trends for bioink applications and the primary considerations guiding the selection and design of current bioink components (i.e., cell types, hydrogels, and additives) were reviewed. The cost, availability, practicality, and basic biological considerations (e.g., cytocompatibility and cell attachment) are the most popular parameters guiding bioink use and development. Today, extrusion bioprinting is the most widely used bioprinting technique. The most reported use of bioinks is the generic characterization of bioink formulations or bioprinting technologies (32%), followed by cartilage bioprinting applications (16%). Similarly, the cell-type choice is mostly generic, as cells are typically used as models to assess bioink formulations or new bioprinting methodologies rather than to fabricate specific tissues. The cell-binding motif arginine-glycine-aspartate is the most common bioink additive. Many articles reported the development of advanced functional bioinks for specific biomedical applications; however, most bioinks remain the basic compositions that meet the simple criteria: Manufacturability and essential biological performance. Alginate and gelatin methacryloyl are the most popular hydrogels that meet these criteria. Our analysis suggests that present-day bioinks still represent a stage of emergence of bioprinting technology.

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“… Tissue engineering evolution: (A) from Petri dishes to biofabrication and organ-on-a-chip. (B) Milestones in bioprinting in the 21 st century ( Kwon et al, 2000 ; Landers et al, 2002 ; Wilson Jr and Boland, 2003 ; Dhariwala et al, 2004 ; Jakab et al, 2008 ; Norotte et al, 2009 ; Wu et al, 2011 ; Skardal et al, 2012 ; Nakayama, 2013 ; Hinton et al, 2015 ; Gao et al, 2015 ; Kang et al, 2016 ; Retting et al, 2016 ; D O’Connell et al, 2016 ; Gladman et al, 2016 ; Lee J. H. et al, 2017 ; Pyo et al, 2017 , 2017 ; Bernal et al, 2019 ; Skylar-Scott et al, 2019 ; Grigoryan et al, 2019 , 2021 ; Jodat et al, 2020 ; Chen et al, 2020 ; Urciuolo et al, 2020 ; Brassard et al, 2021 ; Maharjan et al, 2021 ; Markert et al, 2021 ; De Santis et al, 2021 ). (C) Milestones in Organ-on-Chip in the 21 st century ( Huh et al, 2010 ; Nakao et al, 2011 ; Franco and Gerhardt, 2012 ; Jang et al, 2013 ; Nguyen et al, 2013 ; Wei-Xuan et al, 2013 ; Bersini et al, 2014 ; Rigat-Brugarolas et al, 2014 ; Torisawa et al, 2014 ; Choi et al, 2015 ; Park et al, 2015 ; Miller and Shuler, 2016 ; Rosa et al, 2016 ; Wufuer et al, 2016 ; Zhang et al, 2017a , 2021 ; Lind et al, 2017 ; Vernetti et al, 2017 ; Wikswo et al, 2017 ; Ingber et al, 2018 ; Lee et al, 2018 ; Marturano-Kruik et al, 2018 ; Achberger et al,...…”

Section: Introductionmentioning

confidence: 99%

Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies

Celikkin

Presutti

Maiullari

et al. 2021

Front. Bioeng. Biotechnol.

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In the last decades, biomedical research has significantly boomed in the academia and industrial sectors, and it is expected to continue to grow at a rapid pace in the future. An in-depth analysis of such growth is not trivial, given the intrinsic multidisciplinary nature of biomedical research. Nevertheless, technological advances are among the main factors which have enabled such progress. In this review, we discuss the contribution of two state-of-the-art technologies–namely biofabrication and organ-on-a-chip–in a selection of biomedical research areas. We start by providing an overview of these technologies and their capacities in fabricating advanced in vitro tissue/organ models. We then analyze their impact on addressing a range of current biomedical challenges. Ultimately, we speculate about their future developments by integrating these technologies with other cutting-edge research fields such as artificial intelligence and big data analysis.

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Symbiotic Photosynthetic Oxygenation within 3D-Bioprinted Vascularized Tissues

Cited by 79 publications

References 65 publications

Freeze‐Casting with 3D‐Printed Templates Creates Anisotropic Microchannels and Patterned Macrochannels within Biomimetic Nanofiber Aerogels for Rapid Cellular Infiltration

Freeze‐Casting with 3D‐Printed Templates Creates Anisotropic Microchannels and Patterned Macrochannels within Biomimetic Nanofiber Aerogels for Rapid Cellular Infiltration

Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress

Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies

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