Symbiotic Relationships with Fungi: From Mutualism to Parasitism

El-Metwally, Mohammad Magdy; Mekawey, Amal A. I.; El-Halmouch, Y.; Naga, Nourhan G.

doi:10.1007/978-3-031-28307-9_15

Cited by 3 publications

(1 citation statement)

References 299 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to biofilm formation, P. aeruginosa possesses various virulence factors such as alginate, lipase, protease, chitinase, aminopeptidase, and elastase, which aid in microbial dissemination. Quorum sensing (QS) regulates this virulence behavior by the release of signaling molecules known as autoinducers 6 , 7 . Autoinducers support cell–cell communication and cross-talk between two different species that coexist in the same area 8 .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Pseudomonas aeruginosa quorum sensing by methyl gallate from Mangifera indica

Naga,

Zaki,

El-Badan

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Antipathogenic drugs are a potential source of therapeutics, particularly following the emergence of multiple drug-resistant pathogenic microorganisms in the last decade. The inhibition of quorum sensing (QS) is an advanced antipathogenic approach for suppression of bacterial virulence and dissemination. This study aimed to investigate the inhibitory effect of some Egyptian medicinal plants on the QS signaling system of Pseudomonas aeruginosa. Among the tested plants, Mangifera indica exhibited the highest quorum sensing inhibition (QSI) activity against Chromobacterium violaceum ATCC 12472. Four pure compounds were extracted and identified; of these, methyl gallate (MG) showed the most potent QSI. MG had a minimum inhibitory concentration (MIC) of 512 g/mL against P. aeruginosa strains PAO1, PA14, Pa21, Pa22, Pa23, Pa24, and PAO-JP2. The virulence factors of PAO1, PA14, Pa21, Pa22, Pa23, and Pa24 were significantly inhibited by MG at 1/4 and 1/2 sub-MICs without affecting bacterial viability. Computational insights were performed by docking the MG compound on the LasR receptor, and the QSI behavior of MG was found to be mediated by three hydrogen bonds: Trp60, Arg61, and Thr75. This study indicates the importance of M. indica and MG in the inhibition and modulation of QS and QS-related virulence factors in P. aeruginosa.

show abstract

Section: Introductionmentioning

confidence: 99%

Inhibition of Pseudomonas aeruginosa quorum sensing by methyl gallate from Mangifera indica

Naga,

Zaki,

El-Badan

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

An insight on the powerful of bacterial quorum sensing inhibition

Naga,

Shaaban,

El-Metwally

2024

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Bacteria have their own language through which they communicate with one another like all higher organisms. So, many researchers are working hard to identify and comprehend the components of this bacterial communication, known as quorum sensing (QS). In quorum sensing, bacteria use signaling molecules called autoinducers (AIs) to exchange information. Many natural compounds and extraction techniques have been intensively studied to disrupt bacterial signaling and examine their effectiveness for bacterial pathogenesis control. Quorum sensing inhibitors can interfere with QS and block the action of AI signaling molecules. Recent research indicates that quorum sensing inhibitors (QSIs) and quorum quenching enzymes (QQEs) show great promise in reducing the pathogenicity of bacteria and inhibiting biofilm synthesis. In addition, the effectiveness of QQEs and QSIs in experimental animal models was demonstrated. These are taken into account in the development of innovative medical devices, such as dressings and catheters, to prevent bacterial infections. The present review highlights this aspect with a prospective vision for its development and application.

show abstract