Sympathetic Postganglionic Mechanism

Burn, J. H.; Rand, M. J.

doi:10.1038/184163a0

Cited by 287 publications

(91 citation statements)

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“…The bath was bubbled with 02. Rabbit's and guinea-pig's atria were set up in the isolated organ bath, as described by Burn (1952 and with the sympathetic nerve were prepared as follows. Rabbits were stunned and killed, and quickly tied out on a table.…”

Section: Methodsmentioning

confidence: 99%

“…The bath was bubbled with 02. Rabbit's and guinea-pig's atria were set up in the isolated organ bath, as described by Burn (1952).…”

Section: Methodsmentioning

confidence: 99%

“…Both drugs abolished the accelerating action of acetylcholine in the presence of atropine, but they augmented the action of tyramine, and did not reduce that of amphetamine. In the vessels of the perfused rabbit ear they abolished the constrictor effect of nervous stimulation and of acetylcholine, but increased that of tyramine.The substance choline 2,6-xylyl ether (TM10; hereafter called choline xylyl ether) was synthesized by Hey, and Willey discovered that it blocked the response to stimulation of postganglionic adrenergic fibres without affecting the actions of added adrenaline or noradrenaline (Hey and Willey, 1954). This action was studied in greater detail by Exley (1957).…”

mentioning

confidence: 99%

“…The substance choline 2,6-xylyl ether (TM10; hereafter called choline xylyl ether) was synthesized by Hey, and Willey discovered that it blocked the response to stimulation of postganglionic adrenergic fibres without affecting the actions of added adrenaline or noradrenaline (Hey and Willey, 1954). This action was studied in greater detail by Exley (1957).…”

mentioning

confidence: 99%

“…The second pair of electrodes were placed around the stellate ganglion itself. The electrodes were of a pattern described by Burn and Rand (1959) with a channel in the holder through which a small amount of solution was constantly siphoned from the bath so that the portion of nerve stimulated was continually irrigated by fully oxygenated solution. The other end of the atria was tied to a spring lever.…”

mentioning

confidence: 99%

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The Action of Sympathetic Blocking Agents on Isolated and Innervated Atria and Vessels

Huković

1960

British Journal of Pharmacology and Chemotherapy

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A preparation is described of isolated rabbit atria with both vagus and sympathetic nerves. The action on it of bretylium and of choline 2,6-xylyl ether bromide (TM10) was studied. A concentration of breylium sufficient to abolish the response to sympathetic stimulation also depressed the response to vagal stimulation. The effect was reversible, though more easily with choline xylyl ether. Both drugs abolished the accelerating action of acetylcholine in the presence of atropine, but they augmented the action of tyramine, and did not reduce that of amphetamine. In the vessels of the perfused rabbit ear they abolished the constrictor effect of nervous stimulation and of acetylcholine, but increased that of tyramine.The substance choline 2,6-xylyl ether (TM10; hereafter called choline xylyl ether) was synthesized by Hey, and Willey discovered that it blocked the response to stimulation of postganglionic adrenergic fibres without affecting the actions of added adrenaline or noradrenaline (Hey and Willey, 1954). This action was studied in greater detail by Exley (1957). Recently bretylium, N-obromobenzyl-N-ethyl-NN-dimethylammonium ptoluene sulphonate, has been introduced by Boura, Green, McCoubrey, Laurence, Moulton, and Rosenheim (1959) as a substance having a similar action which can be used clinically. The action of these two substances on the isolated atria of the rabbit heart has been examined using in some experiments the sympathetically innervated preparation which has been recently described (Hukovid, 1959), and, in some, a doubly innervated preparation so that the vagal fibres or the sympathetic fibres could be stimulated at will. The substances have also been examined for their action on the perfused vessels of the rabbit ear. METHODSTn all experiments on the atria the solution used was: NaCl 9.0 g., KCl 0.42 g., CaCI2 0.24 g., dextrose 2.0 g. and NaHCO3 0.5 g. in 1 litre. The temperature of the bath was 30°. The bath was bubbled with 02. Rabbit's and guinea-pig's atria were set up in the isolated organ bath, as described by Burn (1952 and with the sympathetic nerve were prepared as follows. Rabbits were stunned and killed, and quickly tied out on a table. The skin was removed from the thorax and neck. The vagus nerve and the sympathetic chain of the right side were identified and tied. The trachea and the oesophagus were divided as they entered the thorax. The ventral wall of the chest was removed without disturbing the thymus and neighbouring tissues. The vertebral column was divided with strong scissors between the cervical and thoracic vertebrae. The main vessels were divided in front of the 3rd thoracic vertebra, and the vertebral column was again divided between the 2nd and 3rd thoracic vertebrae. All skeletal muscles were removed and the preparation was immersed in oxygenated solution at 30°. The preparation was left in this solution at least 5 min. The preparation was then cleaned again and fixed on the short part of an L-shaped rod, and then was again immersed in the solution where it remained. Th...

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Section: Methodsmentioning

confidence: 99%

“…The bath was bubbled with 02. Rabbit's and guinea-pig's atria were set up in the isolated organ bath, as described by Burn (1952).…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%