Sympathetic predominance is associated with impaired endothelial progenitor cells and tunneling nanotubes in controlled-hypertensive patients

Cavanagh, Elena M.V. de; González, Sergio; Inserra, Felipe; Forcada, Pedro; Castellaro, Carlos; Chiabaut-Svane, Jorge; Obregon, S.; Casarini, María Jesús; Kempny, Pablo; Kotliar, C.

doi:10.1152/ajpheart.00955.2013

Cited by 16 publications

(9 citation statements)

References 38 publications

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“…Associations have been demonstrated between increased oxidative stress and enhanced susceptibility of brain tissue to oxidative damage 41 and between increased EPC level and sympathetic under-activity/parasympathetic over-activity. 42 Our results not only support that EPCs play a potential role in vascular repair and tissue healing 43 but also imply that the vascular and neuronal repair mediators proportionally compensate for the loss of brain volume as PD progresses. In the future, interactions between oxidative stress and brain microstructures should be studied directly using animal models.…”

Section: Discussionsupporting

confidence: 67%

Association Between Autonomic Impairment and Structural Deficit in Parkinson Disease

Chen

et al. 2016

Medicine

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Patients with Parkinson disease (PD) have impaired autonomic function and altered brain structure. This study aimed to evaluate the relationship of gray matter volume (GMV) determined by voxel-based morphometry (VBM) to autonomic impairment in patients with PD.Whole-brain VBM analysis was performed on 3-dimensional T1-weighted images in 23 patients with PD and 15 sex- and age-matched healthy volunteers. The relationship of cardiovascular autonomic function (determined by survey) to baroreflex sensitivity (BRS) (determined from changes in heart rate and blood pressure during the early phase II of the Valsalva maneuver) was tested using least-squares regression analysis. The differences in GMV, autonomic parameters, and clinical data were correlated after adjusting for age and sex.Compared with controls, patients with PD had low BRS, suggesting worse cardiovascular autonomic function, and smaller GMV in several brain locations, including the right amygdala, left hippocampal formation, bilateral insular cortex, bilateral caudate nucleus, bilateral cerebellum, right fusiform, and left middle frontal gyri. The decreased GMVs of the selected brain regions were also associated with increased presence of epithelial progenitor cells (EPCs) in the circulation.In patients with PD, decrease in cardiovascular autonomic function and increase in circulating EPC level are associated with smaller GMV in several areas of the brain. Because of its possible role in the modulation of the circulatory EPC pool and baroreflex control, the left hippocampal formation may be a bio-target for disease-modifying therapy and treatment monitoring in PD.

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Section: Discussionsupporting

confidence: 67%

Association Between Autonomic Impairment and Structural Deficit in Parkinson Disease

Chen

et al. 2016

Medicine

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“…EPCs CD34+/CD133+ increase with the RR, protecting patients from the possibility of a new coronary syndrome. 36 As demonstrated, their title varies in relation to the levels of norepinephrine 37 and, accordingly, an increase in inverse proportion to norepinephrine levels occurs. Their action maintains healthy vascular endothelium, especially from damage induced by oxidative stress.…”

Section: Discussionmentioning

confidence: 96%

Thoughts modulate the expression of inflammatory genes and may improve the coronary blood flow in patients after a myocardial infarction

Lin

Marinova

Rubino

et al. 2018

Journal of Traditional and Complementary Medicine

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BackgroundMental stress is one of the main risk factors for cardiovascular disease. Meditation and music listening are two techniques that are able to counteract it through the activation of specific brain areas, eliciting the so-called Relaxing Response (RR). Epidemiological evidence reveals that the RR practice has a beneficial prognostic impact on patients after myocardial infarction. We aimed to study the possible molecular mechanisms of RR underlying these findings.MethodsWe enrolled 30 consecutive patients after myocardial infarction and 10 healthy controls. 10 patients were taught to meditate, 10 to appreciate music and 10 did not carry out any intervention and served as controls. After training, and after 60 days of RR practice, we studied the individual variations, before and after the relaxation sessions, of the vital signs, the electrocardiographic and echocardiographic parameters along with coronary flow reserve (CFR) and the carotid's intima media thickness (IMT). Neuro-endocrine-immune (NEI) messengers and the expression of inflammatory genes (p53, Nuclear factor Kappa B (NfKB), and toll like receptor 4 (TLR4)) in circulating peripheral blood mononuclear cells were also all observed.ResultsThe RR results in a reduction of NEI molecules (p < 0.05) and oxidative stress (p < 0.001). The expression of the genes p53, NFkB and TLR4 is reduced after the RR and also at 60 days (p < 0.001). The CFR increases with the relaxation (p < 0.001) and the IMT regressed significantly (p < 0.001) after 6 months of RR practice.ConclusionsThe RR helps to advantageously modulate the expression of inflammatory genes through a cascade of NEI messengers improving, over time, microvascular function and the arteriosclerotic process.

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“…TNT-mediated communication between MSCs and renal tubular cells with extensive spontaneous intercellular exchange of cytoplasmic material contributes to renal physiology (Plotnikov et al, 2010; Domhan et al, 2011; de Cavanagh et al, 2014), as has been shown by MSC-derived EVs (Grange et al, 2014; Gu et al, 2016). Similarly, the regulation of TNTs between neural stem cells and brain microvascular endothelial cells could rescue brain function (Wang et al, 2016).…”

Section: Tnts and Evs: Implications In Regenerative/repair Processesmentioning

confidence: 99%

Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links

Nawaz

Fatima

2017

Front. Mol. Biosci.

105

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The process of intercellular communication seems to have been a highly conserved evolutionary process. Higher eukaryotes use several means of intercellular communication to address both the changing physiological demands of the body and to fight against diseases. In recent years, there has been an increasing interest in understanding how cell-derived nanovesicles, known as extracellular vesicles (EVs), can function as normal paracrine mediators of intercellular communication, but can also elicit disease progression and may be used for innovative therapies. Over the last decade, a large body of evidence has accumulated to show that cells use cytoplasmic extensions comprising open-ended channels called tunneling nanotubes (TNTs) to connect cells at a long distance and facilitate the exchange of cytoplasmic material. TNTs are a different means of communication to classical gap junctions or cell fusions; since they are characterized by long distance bridging that transfers cytoplasmic organelles and intracellular vesicles between cells and represent the process of heteroplasmy. The role of EVs in cell communication is relatively well-understood, but how TNTs fit into this process is just emerging. The aim of this review is to describe the relationship between TNTs and EVs, and to discuss the synergies between these two crucial processes in the context of normal cellular cross-talk, physiological roles, modulation of immune responses, development of diseases, and their combinatory effects in tissue repair. At the present time this review appears to be the first summary of the implications of the overlapping roles of TNTs and EVs. We believe that a better appreciation of these parallel processes will improve our understanding on how these nanoscale conduits can be utilized as novel tools for targeted therapies.

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Sympathetic predominance is associated with impaired endothelial progenitor cells and tunneling nanotubes in controlled-hypertensive patients

Cited by 16 publications

References 38 publications

Association Between Autonomic Impairment and Structural Deficit in Parkinson Disease

Association Between Autonomic Impairment and Structural Deficit in Parkinson Disease

Thoughts modulate the expression of inflammatory genes and may improve the coronary blood flow in patients after a myocardial infarction

Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links

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