Sympatho-adrenal response to hypoglycaemia in infants

Stanek, Brigitte; Lischka, A; Hörtnagl, Helmut; Pollak, Arnold

doi:10.1007/bf00441414

Cited by 4 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 24 This was not supported by a study of human neonates, which demonstrated a marked noradrenergic response to hypoglycaemia. 25 However, in this latter study, hypoglycaemia was induced by abruptly discontinuing high rate glucose infusion and the only SGA infant studied had systemic complications, so the findings may not be applicable to spontaneously occurring hypoglycaemia in otherwise well SGA infants. Increased urinary excretion of catecholamines has been demonstrated for SGA infants during hypoglycaemia but, unfortunately, this particular study did not record plasma catecholamine concentrations.…”

Section: Resultsmentioning

confidence: 77%

Hormonal and metabolic response to hypoglycaemia in small for gestational age infants.

Hawdon

Weddell

Aynsley-Green

et al. 1993

Archives of Disease in Childhood

View full text Add to dashboard Cite

Little is known of the ability of hypoglycaemic infants who are small for gestational age (SGA) to mount the coordinated hormonal and metabolic counterregulatory response that is seen in healthy older subjects during glycopenia. This response was studied in 22 SGA infants (birth weight <10th centile) by measuring the blood concentrations of glucose, intermediary metabolites, and glucoregulatory hormones.Plasma non-esterified fatty acid and blood ketone body concentrations were low, even when blood glucose concentrations were low. Plasma insulin and glucagon varied widely (<1.0-53.1 mU/l and 16-6-87 1 pmol/, respectively). Concentrations of noradrenaline and glucagon were raised, but cortisol and adrenaline were lower than those found in hypoglycaemic adults. There was no relationship between the concentration of any hormone and blood glucose concentration.We postulate that hypoglycaemia and the failure to mobilise alternative fuels in some SGA infants is secondary both to a poorly coordinated counterregulatory hormone response and to a peripheral insensitivity to the actions of the hormones. Those infants, who fail to mount a counterregulatory response, should be identified by accurate and reliable blood glucose monitoring, and an adequate exogenous supply of energy, either enteral or parenteral, should be ensured.

show abstract

Section: Resultsmentioning

confidence: 77%

Hormonal and metabolic response to hypoglycaemia in small for gestational age infants.

Hawdon

Weddell

Aynsley-Green

et al. 1993

Archives of Disease in Childhood

View full text Add to dashboard Cite

show abstract

Developmental Considerations

Parker¹

1997

Endocrinology of Critical Disease

View full text Add to dashboard Cite

40 years neonatology

Pollak

2024

Wien Klin Wochenschr

View full text Add to dashboard Cite

Summary Background A complete review of the development of neonatology in the last 40 years would probably require a compendium with several volumes, to bring to view the remarkable improvements in survival rates and neurodevelopmental outcomes of ill babies in Austria, most industrial countries and to some extent worldwide. The challenge I had to solve here was to integrate my own contributions to the field of neonatology during this period and particularly the contributions of my team from the Division of Neonatology and Pediatric Intensive Care Medicine, Department of Pediatrics and Adolescence Medicine, Medical University Vienna where I was working first as an intern and resident and later had the privilege to become head of department. Aim This very personal review was conceived to showcase the milestones of neonatology where, in my opinion, our department made some meaningful contributions in research and clinical practice during the past 40 years. Methods A total of 10 areas of interest were selected which most likely influenced survival rates of preterm infants born at increasingly younger gestational ages and ameliorated long-term clinical and neurodevelopmental outcomes, including: 1) Construction and continuous modernization of neonatal intensive care units (NICUs). 2) Installation of the “Regionalization Program for NICUs in Vienna”. 3) Treatment of respiratory distress syndrome (RDS) of premature babies. 4) Fine tuning of glucose metabolism for growth and outcome. 5) Neurodevelopmental care. 6) Neonatal hematology. 7) Infection control. 8) The toxoplasma screening program. 9) The newborn screening program. 10) Quality control: the Vermont Oxford Neonatal Network (VONN). Results Over the past four decades advancements in research and technology have allowed a transformative development of neonatal medicine. Survival rates without increased morbidity for very premature infants with gestational ages reaching to what we consider nowadays the border of viability have constantly increased. In my professional life as a neonatologist in Austria I have had the possibility to support and shape some of these developments together with my team. Conclusion As we look ahead it is imperative to build upon the progress made, harnessing the power of science and technology to further improve the survival and quality of life for preterm infants in Austria and worldwide. At the same time, neonatology must continue to prioritize ethical reflection and education, fostering a culture of integrity, interdisciplinary collaboration, and the development of guidelines and protocols that uphold ethical standards while addressing the evolving needs and complexities of neonatal medicine.

show abstract

Sympatho-adrenal response to hypoglycaemia in infants

Cited by 4 publications

References 20 publications

Hormonal and metabolic response to hypoglycaemia in small for gestational age infants.

Hormonal and metabolic response to hypoglycaemia in small for gestational age infants.

Developmental Considerations

40 years neonatology

Contact Info

Product

Resources

About