Sympatho-inhibitory baroreflex in conscious rabbits: simultaneous recordings of sympathetic and aortic nerve activity

Tafil-Klawe, Małgorzata; Klawe, Jacek J.; Majcherczyk, S; Trzebski, A

doi:10.1016/0165-1838(89)90150-1

Cited by 11 publications

(10 citation statements)

References 10 publications

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“…Their results did not include the baroreceptor sensitivity assessment. Nonetheless, the sympathetic system activation, which includes manifestations such as the HR increase, is known to be associated with a lower BRS (4,5,6). Our results of lower BRS being associated with worse outcome are therefore consistent with the pervious results which indicated an association between sympathetic activation and unfavourable outcome after SAH.…”

Section: Discussionsupporting

confidence: 91%

“…Besides the occurrence of cardiovascular complications, other mechanisms may explain the association between decreased BRS and poor outcome, in particular, the consequences of increased activity of the sympathetic system which is known to be associated with lower BRS (4,5,6). Indeed, sympathetic activation is associated with increased platelet aggregation, hyperglycaemia, inflammation and increase of the blood-brain barrier's permeability (29).…”

Section: Discussionmentioning

confidence: 99%

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Baroreflex Impairment After Subarachnoid Hemorrhage Is Associated With Unfavorable Outcome

Nasr

Gaio

Czosnyka

et al. 2018

Stroke

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Baroreflex Impairment After Subarachnoid Hemorrhage Is Associated With Unfavorable Outcome

Nasr

Gaio

Czosnyka

et al. 2018

Stroke

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“…Unilateral electrical stimulation of the nucleus tractus solitarius increased CBF in rats with cervical cordotomy and vagotomy (79), whereas lesions within the nucleus tractus solitarius impaired CA (51). In addition, stimulation of baroreceptors influences cerebral vasomotion (34,111,112). Sinoaortic denervation eliminates cerebral vasodilatation during marked acute hypertension (112), and, during baroreflex deactivation, there are elevations in efferent sympathetic activity in the cervical sympathetic trunk (111).…”

Section: Dynamic Systemic Vascular Regulation (Arterial Baroreflex)mentioning

confidence: 99%

“…In addition, stimulation of baroreceptors influences cerebral vasomotion (34,111,112). Sinoaortic denervation eliminates cerebral vasodilatation during marked acute hypertension (112), and, during baroreflex deactivation, there are elevations in efferent sympathetic activity in the cervical sympathetic trunk (111). Moreover, hemorrhage-induced baroreceptor deactivation causes mild cerebral vasoconstriction (34).…”

Section: Dynamic Systemic Vascular Regulation (Arterial Baroreflex)mentioning

confidence: 99%

Cerebral blood flow during exercise: mechanisms of regulation

Ogoh

Ainslie

2009

Journal of Applied Physiology

436

366

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The response of cerebral vasculature to exercise is different from other peripheral vasculature; it has a small vascular bed and is strongly regulated by cerebral autoregulation and the partial pressure of arterial carbon dioxide (Pa(CO(2))). In contrast to other organs, the traditional thinking is that total cerebral blood flow (CBF) remains relatively constant and is largely unaffected by a variety of conditions, including those imposed during exercise. Recent research, however, indicates that cerebral neuronal activity and metabolism drive an increase in CBF during exercise. Increases in exercise intensity up to approximately 60% of maximal oxygen uptake produce elevations in CBF, after which CBF decreases toward baseline values because of lower Pa(CO(2)) via hyperventilation-induced cerebral vasoconstriction. This finding indicates that, during heavy exercise, CBF decreases despite the cerebral metabolic demand. In contrast, this reduced CBF during heavy exercise lowers cerebral oxygenation and therefore may act as an independent influence on central fatigue. In this review, we highlight methodological considerations relevant for the assessment of CBF and then summarize the integrative mechanisms underlying the regulation of CBF at rest and during exercise. In addition, we examine how CBF regulation during exercise is altered by exercise training, hypoxia, and aging and suggest avenues for future research.

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“…11 Aengevaeren et al compared 2 groups: 11 master athletes to the cerebral vasculature is available from data in rabbits showing an increase in sympathetic activity recorded in the sympathetic cervical trunk after baroreflex deactivation. 34 Sympathetic activity has been shown to increase the cerebrovascular vasomotor tone, 35,36 which is the main parameter influencing CA. 37 Vagal activity has also been shown to affect cerebral circulation and CA 33,38,39 and is more associated with BRS than sympathetic activity.…”

Section: Inverse Correlation Between Brs and Camentioning

confidence: 99%