Symptom burden, psychological distress, and symptom management status in hospitalized patients with advanced cancer: a multicenter study in China

He, Yi; Pang, Ying; Su, Zhongge; Zhou, Yijun; Wang, Y.; Lu, Yuefeng; Jiang, Yu; Han, Xinkun; Song, Lihua; Wang, L.; Li, Z.; Lv, Xiao; Wang, Y.; Yao, Jingyu; Liu, X.; Zhou, Xiaoyi; He, Shuangzhi; Zhang, Y.; Li, J.; Wang, B.; Tang, Lili

doi:10.1016/j.esmoop.2022.100595

Cited by 15 publications

(18 citation statements)

References 36 publications

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“…Furthermore, distant metastasis, emotional distress, depression, and cognitive impairment are independently predictive of SI. Consistent with our previous research, 27% of the advanced cancer patients who participated in this study reported a high multidimensional symptom burden [ 41 ]. Lage et al propose that 40.2% of advanced cancer patients have functional impairment accompanied by severe physical and psychological symptoms [ 42 ].…”

Section: Resultssupporting

confidence: 91%

Suicidal ideation in Chinese patients with advanced breast cancer: a multi-center mediation model study

Zhang,

He,

Pang

et al. 2024

BMC Psychol

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Purpose The pathways underpinning suicide ideation (SI) and certain physical and psychological factors in patients with advanced breast cancer remain unclear. This study develops and validates a mediation model that delineates the associations between several multidimensional variables and SI in Chinese patients with advanced breast cancer. Methods Patients with advanced breast cancer (n = 509) were recruited as study participants from 10 regional cancer centers across China from August 2019 to December 2020. Participants were required to complete five questionnaires using an electronic patient-reported outcomes (ePRO) system: 9 item- Patient Health Questionnaire (PHQ-9), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), 5-level EQ-5D (EQ-5D-5L), and MD Anderson Symptom Inventory (MDASI). Risk factors for SI were identified using multivariable logistic regression, and inputted into serial multiple mediation models to elucidate the pathways linking the risk factors to SI. Results SI prevalence was 22.8% (116/509). After adjusting for covariates, depression (odds ratio [OR] = 1.384), emotional distress (OR = 1.107), upset (OR = 0.842), and forgetfulness (OR = 1.236) were identified as significant independent risk factors (all p < 0.05). The ORs indicate that depression and distress have the strongest associations with SI. Health status has a significant indirect effect (OR=-0.044, p = 0.005) and a strong total effect (OR=-0.485, p < 0.001) on SI, mediated by insomnia severity and emotional distress. Conclusions There is a high SI prevalence among Chinese patients with advanced breast cancer. Our analysis revealed predictive pathways from poor health to heightened SI, mediated by emotional distress and insomnia. Regular management of distress and insomnia can decrease suicide risk in this vulnerable population.

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Section: Resultssupporting

confidence: 91%

Suicidal ideation in Chinese patients with advanced breast cancer: a multi-center mediation model study

Zhang,

He,

Pang

et al. 2024

BMC Psychol

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“…Cancer is a serious disease that is largely refractory and has a long course or treatment cycle. Throughout the cancer trajectory, patients with advanced cancer have experienced a variety of physical and psychological symptoms 4 . Patients’ spirituality is also seriously affected during the disease course.…”

Section: Introductionmentioning

confidence: 99%

Exploring the spiritual needs of patients with advanced cancer in China: a qualitative study

Cheng,

Chen,

Duan

et al. 2024

Sci Rep

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This qualitative study aimed to gain a deep understanding of the spiritual needs of patients with advanced cancer. A qualitative study using semi-structured interviews was conducted. The interviews were audio-recorded, transcribed verbatim, and subjected to thematic analysis. Two researchers coded the interviews independently in NVivo 12 plus and developed major themes and subthemes by inductive and constant comparison. This study was conducted in the inpatient ward of a tertiary cancer hospital in Hunan Province, Chinese Mainland. Eligible participants with advanced cancer were recruited using the purposive sampling method. The sample size was determined by data saturation. All interviews were conducted face-to-face individually from May 2021 to July 2021. A total of 13 patients with advanced cancer patients were interviewed. Six themes were identified, namely being treated as normal and independent individuals, receiving and giving love, seeking inner peace, connecting with spiritual sources, finding meaning and purpose, and preparing for death. Different categories of spiritual needs of patients with advanced cancer were identified in this study. Healthcare professionals need to develop interventions that aim to meet patients’ spiritual needs.

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“… 2 Numerous reports indicate that patients with advanced cancer experience various symptoms due to treatment in addition to the cancer itself. 3 , 4 Patients with advanced cancer have reported fatigue (72%), pain (67%), sleep impairment (45%), anxiety (30%), and depression (35%). 5 Symptoms in patients with advanced cancer were related to higher mortality, a longer length of hospital stay, an increased readmission rate, lower quality of life, and a lower ability to participate in activities of daily living 6 , 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Symptom profiles and related factors among patients with advanced cancer: A latent profile analysis

Hu,

Zhao,

Sun

et al. 2023

Asia-Pacific Journal of Oncology Nursing

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Symptom burden, psychological distress, and symptom management status in hospitalized patients with advanced cancer: a multicenter study in China

Cited by 15 publications

References 36 publications

Suicidal ideation in Chinese patients with advanced breast cancer: a multi-center mediation model study

Suicidal ideation in Chinese patients with advanced breast cancer: a multi-center mediation model study

Exploring the spiritual needs of patients with advanced cancer in China: a qualitative study

Symptom profiles and related factors among patients with advanced cancer: A latent profile analysis

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