Symptom Characteristics and Psychosomatic Profiles in Different Spectrum of Gastroesophageal Reflux Disease

Lim, Chul-Hyun; Choi, Myung‐Gyu; Baeg, Myong Ki; Moon, Sung Jin; Kim, Jin Su; Park, Jae Myung; Lee, In Seok; Kim, Sang Woo; Choi, Kyu Yong

doi:10.5009/gnl.2014.8.2.165

Cited by 13 publications

(11 citation statements)

References 27 publications

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“…In the group of the GERD patients with concomitant obesity the sharp increase of depression level was found 8 , comparing with both the standard and the second group (20±3.72 points at the first group and 14.72±3.3 -at the second group according to the Beck's scale, that corresponds to moderate depression level and significantly higher than in healthy individuals) (p<0.05). Also, the patients had high level of anxiety, which reached 41.28±5.82 points for personal anxiety and 40.36±6.68 points for reactive one in the first group and 40.12±7.18 points for personal anxiety and 38.24±8.3 for reactive anxiety in the second group.…”

Section: Resultsmentioning

confidence: 94%

The features of psycho-vegetative disorders and their role in the pathogenesis of gastroesophageal reflux disease with obesity

Oparin

Korniienko

Oparin³

et al. 2015

Bangladesh J Med Sci

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Abstract:Background: Gastroesophageal reflux disease (GERD) is a disease of the XXI century, affecting the population in the developed countries. There is a clear tendency to increasing of gastroesophageal reflux disease among people of young age. Aim: The aim of the study is to determine the characteristics and role of psychosomatic and vegetative state disorders in the pathogenesis of GERD with concomitant obesity. Materials and methods: 50 young patients with GERD were examined during the study. Depending on the presence or absence of concomitant obesity, two groups were formed. They underwent pH-metery, ultrasonic scanning. State of psychosomatic, vegetative statuses and quality of life we determined by the questionnaires of Beck, Spielberg, Sheehan, Wayne. Results: During the ultrasound examination we determined the esophageal opening diameter, the thickness of esophageal wall, the esophagus width in the lower one third of the esophagus differed significantly in 2 groups of patients (p<0.05). In the group of the GERD patients with concomitant obesity the sharp increase of depression level was found, comparing with both the standard and the second group (p<0.05). It wasn't found the significant difference amount other figures of vegetative and psychosomatic statuses in 2 groups of patients (p>0.05). The patients with GERD of both groups had significantly higher level of motor-evacuation and psycho-vegetative disorders comparing with healthy people (p<0.05). Conclusion: GERD patients have pronounced motor-evacuation disorders and significantly greater manifestations of psycho-vegetative disorders which were more pronounced in gastroesophageal reflux disease patients with concomitant obesity.

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Section: Resultsmentioning

confidence: 94%

The features of psycho-vegetative disorders and their role in the pathogenesis of gastroesophageal reflux disease with obesity

Oparin

Korniienko

Oparin³

et al. 2015

Bangladesh J Med Sci

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“…The antioxidant protection factor (AOP) was assessed according to the level of the serum catalase activity determined with the aid of the standard set of IBL reagents (production Germany), as well as according to the diameter of the celiac trunk and the blood flow velocity in it, since the protective function of the oesophageal mucosa is provided by normal regeneration of the epithelium and adequate state of local blood flow [14,15].…”

Section: Methodsmentioning

confidence: 99%

Peculiarities of State of Protection and Aggression Factors in Patients With Diabetes Mellitus Type Ii and Gastroesophageal Reflux Disease

Kudriavtsev

Oparin

2020

EUREKA: Health Sciences

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Diabetes mellitus is one of the most serious problems of the clinical medicine. This is determined by the fact that it is followed by multisystemic affects, as well as complications on the side of other organs and systems, among which a special place is occupied by gastroesophageal reflux disease. As for the combination and mutual influence of diabetes mellitus and gastroesophageal reflux disease, this issue has not been studied yet, the data of modern literature are not complete and quite contradictory. The aim of the study: to investigate the state of the factors of aggression and protection of the oesophageal mucosa in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease without associated pathology. Method. There were two groups of patients under observation. The first group included 45 patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease (26 men and 19 women). The second group included 38 patients with gastroesophageal reflux disease without associated pathology – 20 men and 18 women. By sex, age, body weight, Helicobacter pylori infection, smoking and alcohol consumption, both groups were comparable. The surveillance program included determining the compensation ratio of carbohydrate metabolism and the state of the factor. The antioxidant protection factor was assessed by the level of catalase activity in the blood serum, as well as by the diameter of the celiac trunk and the blood flow velocity in it. Statistical processing of the obtained data was carried out with the aid of the program WINDOWS STATISTIKA 6.0. For all types of analysis, differences were considered statistically significant with p<0.05. Results. During the study, we found that in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease, as well as in patients with gastroesophageal reflux disease without associated pathology, the level of pH-metry was reduced, but with varying measures of confidence. At the same time, we found that patients with GERD without associated pathology had a decrease in the blood flow velocity in the celiac trunk. Concurrently, we ascertained that the decrease in the blood flow velocity in patients of both groups reduced the diameter of the celiac trunk. Conclusions. In patients with diabetes mellitus type II, concomitant gastroesophageal reflux disease has a subtle clinical presentation that is affected by a significant decline in mucosal sealing protection factors. In patients with GERD without associated pathology, typical clinical manifestations, accompanied by inflammation, acid regurgitation and dyspepsia, are more vivid.

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“…A link of GERD and psychopathological features has already been demonstrated by several studies. [14][15][16][17] We analyzed the data from the patients with refractory GERD symptoms in order to acquire their psychological characteristics, which may be helpful for making diagnosis and clinical strategy.…”

Section: Discussionmentioning

confidence: 99%

The psychological results of 438 patients with persisting GERD symptoms by Symptom Checklist 90-Revised (SCL-90-R) questionnaire

2018

Medicine

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Persisting gastroesophageal reflux disease (GERD) symptoms affect mental state and social activities and mental disorders likewise play a crucial role on GERD symptoms. The aim of this study was to analyze the data of Symptom Checklist by 90-Revised (SCL-90-R) questionnaire in patients with persisting GERD symptom and to explore the impact of psychological factors on them.The patients accepted SCL-90-R questionnaire survey, following endoscopy, high-resolution manometry (HRM) and ambulatory impedance-pH monitoring. Based on these results, we divided patients into different groups. The result of SCL-90-R was also compared by degree of acid reflux, symptoms, symptom duration, and gender.The data from 438 patients were analyzed. All patients were divided into reflux esophagitis (RE) (63, 14.38%); nonerosive gastroesophageal disease (NERD) (106, 24.20%); functional heartburn (FH) (123, 28.08%), and hypersensitive esophagus (HE) (67, 15.29%); depression (DES) (5, 1.14%); hypertensive (10, 3.42%); weak peristalsis (14, 3.20%); achalasia (50, 11.42%). There were significant differences between varied groups judging by DEP, anxiety (ANX), paranoia ideation (PAR), psychoticism (PSY), and global severity index (GSI) domains (all P < .05). The patients with ≥2 years symptom duration presented more scores in DEP, ANX, and PSY (all P < .05). Compared to typical symptoms (n = 185), GERD typical plus atypical symptoms (n = 253) had higher scores of somatization (SOM), ANX, PSY and GSI (all P < .05). Women were found to have significantly higher scores than men in all domains (all P < .05).Our results find significant differences between varied patients with different diagnosis in DEP, ANX, PAR, PSY domains, and GSI. Long symptom duration, typical plus atypical symptoms, and female are more risky for psychological disorders.Abbreviations: ANX = anxiety, DEP = depression, DES = diffuse esophageal spasm, FH = functional heartburn, GERD = gastroesophageal reflux disease, GSI = global severity index, HE = hypersensitive esophagus, HOS = hostility, HRM = highresolution manometry, I-S = interpersonal sensitivity, NERD = nonerosive gastroesophageal disease, O-C = obsessive-compulsive behavior, PAR = paranoia ideation, PHOB = phobic anxiety, PPI = proton pump inhibitor, PSY = psychoticism, RE = reflux esophagitis, SCL-90-R = Symptom Checklist-90-R, SOM = somatization.

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Symptom Characteristics and Psychosomatic Profiles in Different Spectrum of Gastroesophageal Reflux Disease

Cited by 13 publications

References 27 publications

The features of psycho-vegetative disorders and their role in the pathogenesis of gastroesophageal reflux disease with obesity

The features of psycho-vegetative disorders and their role in the pathogenesis of gastroesophageal reflux disease with obesity

Peculiarities of State of Protection and Aggression Factors in Patients With Diabetes Mellitus Type Ii and Gastroesophageal Reflux Disease

The psychological results of 438 patients with persisting GERD symptoms by Symptom Checklist 90-Revised (SCL-90-R) questionnaire

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