The features of psycho-vegetative disorders and their role in the pathogenesis of gastroesophageal reflux disease with obesity

Oparin, A.G.; Korniienko, Daria; Oparin, Aleksey; Lavrova, N.V.; Dvoyashkina, Julia; Khomenko, Ludmila

doi:10.3329/bjms.v14i2.20272

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…In its turn, this article studied and revealed the presence of a higher level of depression in patients with comorbid pathology compared to isolated one, and anxiety -in GERD with insomnia. In addition, the quality of life in patients with GERD was studied [2,23]. At the same time, we have shown that the combination of GERD with NCD and insomnia significantly reduces the indicators of the SF-36 scale, in comparison with isolated pathology.…”

Section: Discussionmentioning

confidence: 97%

Mechanisms of Autonomic Dysfunction Realization During Comorbid Gastroesophageal Reflux Disease and Neurocirculatory Dystonia With Insomnia Among Young People

Oparin

Balaklytska

Khomenko

2020

EUREKA: Health Sciences

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The aim of the study: to optimize diagnostics and treatment of comorbid gastroesophageal reflux disease (GERD) and concomitant neurocirculatory dystonia (NCD) with insomnia among young people by studying autonomic dysfunction and mechanisms of its realization. Methods. The study was conducted in three groups of patients, homogeneous by gender and age. The first group included patients with GERD and insomnia, the second group counted those with NCD and insomnia, and the third group consisted of GERD with NCD and insomnia. We studied the quality of life (SF-36), quality of sleep (PSQI), the presence and severity of depression (PHQ-9), psychosomatic condition (Spielberger-Khanin scale), and determined the presence and severity of autonomic dysfunction syndrome (Wayne questionnaire), acidity of the stomach, ultrasound examination of the esophagus and stomach. Results. The first group revealed sympathicotonia and increase of gastric juice aggression (in the stomach body 0.89±0.05) and reactive (47.2 points) and personal anxiety (52.7 points), which suggests the advisability of use PPI (omeprazole 20 mg 2 times a day for 5 weeks), and melatonin 3 mg per night during 3 weeks. The second group showed parasympathicotonia predominant, a more pronounced decrease in vitality scale (31.5±4.2), and a moderate increase in indicators of reactive (44.0 points) and personal anxiety (46.5 points), which suggests the advisability of use 3 mg of melatonin per night during 3 weeks. The third group demonstrated predominance of parasympathicotonia, motor disorders, a decrease in alkalizing function of antrum (5.4±0.17), depression (81.8 %), and the greatest decrease in indicators of sleep quality (11.7) and quality of life, which suggests the advisability of use PPI (omeprazole 20 mg 2 times per day during 5 weeks), with prokinetics (domperidone 10 mg 3 times per day during 5 weeks), and melatonin 3 mg per night during 3 weeks. Conclusions. Autonomic dysfunction has a key influence on the main pathogenetic factors in the formation of both GERD and NCD and insomnia, and the type of autonomic tone determines the features of the clinical course of both isolated and combined pathology.

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Section: Discussionmentioning

confidence: 97%

Mechanisms of Autonomic Dysfunction Realization During Comorbid Gastroesophageal Reflux Disease and Neurocirculatory Dystonia With Insomnia Among Young People

Oparin

Balaklytska

Khomenko

2020

EUREKA: Health Sciences

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“…Among the many factors impacting the genesis of the motility and evacuation disorders in the upper gastrointestinal tract, disorders of neurohumoral regulation are of particular importance. Melatonin and serotonin play a special role in the mechanisms of these disorders [52,59]. The recent data on the effects these regulatory hormones have on gastrointestinal organs suggest an important role they play in the control over compensatory-adaptive processes and immune homeostasis in the gastric mucosa [60].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

Kamarchuk¹,

Pospelov²,

Harbuz³

et al. 2021

J. Breath Res.

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Significant progress in development of noninvasive diagnostic tools based on breath analysis can be expected if one employs a real-time detection method based on finding a spectral breath profile which would contain some energy characteristics of the analyzed gas mixture. Using the fundamental energy parameters of a quantum system, it is possible to determine with a high accuracy its quantitative and qualitative composition. Among the most efficient tools to measure energy characteristics of quantum systems are sensors based on Yanson point contacts. This paper reports the results of serotonin and melatonin detection as an example of testing the human hormonal background with point-contact sensors, which have already demonstrated their high efficiency in detecting carcinogenic strains of Helicobacter pylori and selective detection of complex gas mixtures. When comparing the values of serotonin and melatonin with the characteristic parameters of the spectral profile of the exhaled breath of each patient, high correlation dependences of the concentration of serotonin and melatonin with a number of characteristic parameters of the response curve of the point-contact sensor were found. The performed correlation analysis was complemented with the regression analysis. As a result, empiric regression relations were proposed to realize in practice the new non-invasive breath test for evaluation of the human hormonal background. Registration of the patient’s breath profile using point-contact sensors makes it possible to easily monitor the dynamics of changes in the human hormonal background and perform a quantitative evaluation of serotonin and melatonin levels in the human body in real time without invasive interventions (blood collection) and expensive equipment or reagents.

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Features of the quality of life in patients with a non-erosive form of gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease in young people

Oparin¹,

Семенова²,

Oparina³

2021

Shidnoevr. z. vnutr. simejnoi med.

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Chronic obstructive pulmonary disease (COPD) is most commonly associated with gastroesophageal reflux disease (GERD). There are practically no studies of the quality of life in young patients. The aim of our study is to study the characteristics of the quality of life of young patients with the combined course of GERD and COPD. We took two groups of patients. The first group with the presence of non-erosive GERD in combination with COPD I-II degree. The second group with isolated non-erosive GERD. The control group included practically healthy individuals. The quality of life of the subjects was determined using international standardized questionnaires GERD-Q, GIQLI, WHOQOL —BREF. It was found, that patients with GERD with concomitant COPD showed a significant decrease in the quality of life in comparison with patients with GERD without concomitant pathology and with the control group. Patients with GERD in combination with COPD mostly had a decrease in the quality of life in the physical and emotional spheres. Patients with isolated GERD had gastroenterological disorders dominate. Decrease in the quality of life in social spheres was significantly observed in both groups. The combined course of GERD and COPD have a degrade influence on quality of life.

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The features of psycho-vegetative disorders and their role in the pathogenesis of gastroesophageal reflux disease with obesity

Cited by 4 publications

References 8 publications

Mechanisms of Autonomic Dysfunction Realization During Comorbid Gastroesophageal Reflux Disease and Neurocirculatory Dystonia With Insomnia Among Young People

Mechanisms of Autonomic Dysfunction Realization During Comorbid Gastroesophageal Reflux Disease and Neurocirculatory Dystonia With Insomnia Among Young People

Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

Features of the quality of life in patients with a non-erosive form of gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease in young people

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