Symptom correlates of eye tracking dysfunction

Bosch, Robert J. van den; Rozendaal, Nico; Mol, J.M.F.

doi:10.1016/0006-3223(87)90092-8

Cited by 19 publications

(17 citation statements)

References 20 publications

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“…The number of catch-up saccades, reflecting efforts to refoveate the target once the eyes have fallen behind, and RMS error did not distinguish these groups at a statistically significant level. These schizophrenia and MTFS findings complement those of other researchers who have reported that putative indices of frontal lobe functioning correlate with pursuit eye tracking performance~Bartfai, Levander, Nyback, Berggren, & Schalling, 1985;Grawe & Levander, 1995;Litman et al, 1991;Malaspina et al, 1994;Scarone, Gambini, Hafele, Bellodi, & Smeraldi, 1987;van den Bosch, Rozendaal, & Mol, 1987!. …”

Section: Multivariate Phenotypesupporting

confidence: 32%

Identifying psychophysiological risk for psychopathology: Examples from substance abuse and schizophrenia research

Iacono

1998

Psychophysiology

101

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A problem confronting the search for psychopathology-related genes concerns the difficulty identifying gene carriers. Psychiatric diagnosis provides imperfect identification of affected individuals, and unaffected gene carriers go undetected. Psychophysiological measures may assist molecular genetic investigations by indicating genetic susceptibility for psychopathology, thus increasing the probability of identifying affected and unaffected gene carriers. Research strategies based on these premises are applied to the study of psychoactive substance use disorders and schizophrenia. Data are presented illustrating (1) that individual differences in inhibitory control involving autonomic and antisaccade eye movement measures and the P3 component of the event-related potential may be sensitive to susceptibility for substance use disorders, and (2) that eye tracking variables may identify genetic risk for schizophrenia.

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Section: Multivariate Phenotypesupporting

confidence: 32%

Identifying psychophysiological risk for psychopathology: Examples from substance abuse and schizophrenia research

Iacono

1998

Psychophysiology

101

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“…SPEM dysfunction, it has been argued, reflects abnormal disinhibition that may also be responsible for schizophrenic attention disorder (Holzman 1987). Studies of SPEM using questionnaire-selected subjects have been somewhat equivocal in their results; whether an association with psychosis proneness was found depended on the scale used (Simons and Katkin 1985; van den Bosch et al 1987). Nevertheless the measure does seem to be maintaining its place as a potential risk indicator for at least some aspect of the vulnerability to schizophrenia, in some families (Clementz et al 1992; Iacono et al 1992).…”

Section: Searching For Endophenotypesmentioning

confidence: 99%

Single Indicator of Risk for Schizophrenia: Probable Fact or Likely Myth?

Claridge

1994

Schizophrenia Bulletin

197

123

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The longitudinal followup strategy in high-risk research is being increasingly complemented by the use of psychosis-proneness scales to select subjects for study who might be vulnerable to schizophrenia and who show differences on laboratory measures that could act as endophenotypic markers for use in genetic investigations. Three types of experimental paradigm have been adopted, drawn from cognitive psychology, psychophysiology, and the neuropsychology of hemisphere function. Results adopting each of these approaches are examined, alongside recent factor-analytic evidence that psychosis-proneness scales currently in use tap up to four different components that map onto the clinical heterogeneity of schizophrenia (and possibly other forms of psychosis). No one of these components clearly emerges as, or points to, a single indicator of risk, though some aspect of neurocognitive functioning seems a likely candidate. Even so, it is argued, the clinical expression of vulnerability must be due to a convergence in an individual of several components of risk since individually (and notably so for "susceptibility to positive symptoms") they are very common in the healthy population. In evaluating the evidence, attention is drawn to two crucially different ways that investigators in schizophrenia research have construed the notion of continuity (1) as subclinical defect (or forme fruste of disease) having varying expression or (2) as biologically based personality dimensions that simultaneously describe the dispositions to aberrations of function leading to degree of illness. It is noted that the model of continuity chosen can significantly shape the way the results of risk research are interpreted and the theories of psychosis to which they give rise.

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“…[47][48][49][50] Nevertheless, several studies have reported a significant relationship between ETD and "psychotic-like" symptoms and/or perceptual abnormalities in clinical and normal populations. [51][52][53][54] For example, scores on the Perceptual Aberration Scale are significantly associated with pursuit quality among schizophrenic patients 55 and with pursuit variability among undergraduates. 56 One limitation of our study is that we selected our groups using an imperfect measure of schizotypy: the Perceptual Aberration Scale is thought to generate an admixture of schizotypes and an unknown proportion of individuals who experience perceptual anomalies for reasons unrelated to schizophrenia risk.…”

Section: Commentmentioning

confidence: 99%

Antisaccades and Smooth Pursuit Eye Tracking and Schizotypy

O’Driscoll

Lenzenweger²,

Holzman³

1998

Arch Gen Psychiatry

129

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Subjects with elevated Perceptual Aberration Scale scores have performance deficits on oculomotor tasks that have been linked to latent liability to schizophrenia, namely, smooth pursuit and antisaccade performance. The antisaccade errors in the schizotype group were primarily perseverations, a behavioral pattern often associated with frontal lobe dysfunction and observed in the performance of schizophrenic patients.

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Symptom correlates of eye tracking dysfunction

Cited by 19 publications

References 20 publications

Identifying psychophysiological risk for psychopathology: Examples from substance abuse and schizophrenia research

Identifying psychophysiological risk for psychopathology: Examples from substance abuse and schizophrenia research

Single Indicator of Risk for Schizophrenia: Probable Fact or Likely Myth?

Antisaccades and Smooth Pursuit Eye Tracking and Schizotypy

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