2021
DOI: 10.1101/2021.03.22.436517
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Symptomatic and Neurotrophic Effects of GABAA Receptor Positive Allosteric Modulation in a Mouse Model of Chronic Stress

Abstract: Chronic stress is a major risk factor for developing depressive disorders and animal models of stress recapitulate behavioral, cellular and molecular changes that are observed in human depression. Individuals exposed to chronic stress, or patients with MDD experience mood and cognitive dysfunctions. This is in part due to neuronal shrinkage in brain regions involved in several cognitive functions such as the prefrontal cortex (PFC) and the hippocampus (HPC). Also in the context of depression and chronic stress… Show more

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