Symptomatic Effect of a Low-Dose Antacid Regimen in Reflux Oesophagitis

Weberg, R.; Berstad, Arnold

doi:10.3109/00365528909093066

Cited by 58 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the drug is not suitable for severe cases [65]. Though the endoscopic healing rate for erosive GERD by frequent dosing of antacid has been reported to be no better than placebo [67,68], the relief rate for GERD symptoms is significantly better than that of a placebo [63,69]. Antacid is a neutralizer of acid and is effective immediately.…”

Section: Cq: Is An Acid Suppressant Effective For the Treatment Of Gerd?mentioning

confidence: 99%

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015

et al. 2016

View full text Add to dashboard Cite

As an increase in gastroesophageal reflux disease (GERD) has been reported in Japan, and public interest in GERD has been increasing, the Japanese Society of Gastroenterology published the Evidence-based Clinical Practice Guidelines for GERD (1st edition) in 2009. Six years have passed since its publication, and there have been a large number of reports in Japan concerning the epidemiology, pathophysiology, treatment, and Barrett's esophagus during this period. By incorporating the contents of these reports, the guidelines were completely revised, and a new edition was published in October 2015. The revised edition consists of eight items: epidemiology, pathophysiology, diagnosis, internal treatment, surgical treatment, esophagitis after surgery of the upper gastrointestinal tract, extraesophageal symptoms, and Barrett's esophagus. This paper summarizes these guidelines, particularly the parts related to the treatment for GERD. In the present revision, aggressive proton pump inhibitor (PPI) maintenance therapy is recommended for severe erosive GERD, and on-demand therapy or continuous maintenance therapy is recommended for mild erosive GERD or PPI-responsive non-erosive GERD. Moreover, PPI-resistant GERD (insufficient symptomatic improvement and/or esophageal mucosal break persisting despite the administration of PPI at a standard dose for 8 weeks) is defined, and a standard-dose PPI twice a day, change in PPI, change in the PPI timing of dosing, addition of a prokinetic drug, addition of rikkunshito (traditional Japanese herbal medicine), and addition of histamine H2-receptor antagonist are recommended for its treatment. If no improvement is observed even after these treatments, pathophysiological evaluation with esophageal impedancepH monitoring or esophageal manometry at an expert facility for diseases of the esophagus is recommended.

show abstract

Section: Cq: Is An Acid Suppressant Effective For the Treatment Of Gerd?mentioning

confidence: 99%

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015

et al. 2016

View full text Add to dashboard Cite

show abstract

“…They provide rapid but only transient symptom relief and do not heal esophagitis or prevent GERD complications. 104,105 Sucralfate is not absorbed through the gastrointestinal mucosa and forms a glue-like material when it reacts with the gastric acid. This material sticks to erosions and exudates forming a protective layer.…”

Section: Cytoprotective Agents and Antacidsmentioning

confidence: 99%

Therapeutic Strategies for Laryngeal Manifestations of Gastroesophageal Reflux Disease

Yüksel

Vaezi

2013

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

Gastroesophageal reflux disease is increasingly associated with ear, nose, and throat symptoms, including laryngitis. Many patients are unaware of the gastroesophageal etiology of their symptoms. A variety of criteria are used to diagnose this condition, including laryngoscopy, esophagogastroduodenoscopy, and the use of ambulatory pH and impedance monitoring. However, no test serves as the gold standard for the diagnosis given their lack of sensitivity and specificity for reflux disease. Numerous trials have assessed the role of proton pump inhibitor therapy in patients with laryngopharyngeal reflux and most have revealed no benefit to acid suppression over placebo. Despite many uncertainties there has been some progress regarding the role of acid-suppressive therapy as well as other agents in this unique group of patients. In this review we explore therapeutic options and their rationale for patients with laryngeal signs and symptoms.

show abstract

“…Antacids, such as magnesium hydroxide, aluminium hydroxide and calcium carbonate, were considered the treatment of choice for acid-related disorders before the advent of more potent acid suppression drugs [30]. Antacids provide rapid symptom relief, but the effect is short lived, and they do not adequately heal erosive esophagitis or prevent GERD-related complications.…”

Section: Antacids and Mucosal Protective Agentsmentioning

confidence: 99%

Gastroesophageal reflux disease

Fock

Poh

2010

J Gastroenterol

View full text Add to dashboard Cite

GERD is a common chronic gastrointestinal disorder, and its prevalence in Asia is increasing. Classical symptoms of heartburn and regurgitation are common presentations. There is no standard criterion for the diagnosis of GERD, and 24-h pH monitoring lacks sensitivity in NERD. Furthermore, diagnostic studies for gastroesophageal reflux disease have several limitations. A short course of PPI is often used in clinical practice as a diagnostic test for gastroesophageal reflux disease. Elderly patients with GERD usually present with atypical manifestations, and they tend to develop more severe disease. PPI remains the mainstay of treatment for GERD. In a subset of patients who wish to discontinue maintenance treatment, anti-reflux surgery is a therapeutic option.

show abstract

Symptomatic Effect of a Low-Dose Antacid Regimen in Reflux Oesophagitis

Cited by 58 publications

References 15 publications

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015

Therapeutic Strategies for Laryngeal Manifestations of Gastroesophageal Reflux Disease

Gastroesophageal reflux disease

Contact Info

Product

Resources

About