Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin

Mibielli, Marco Antonio; Nunes, Carlos Pereira; Scussel, Ari Boulanger; Neto, Mendel Suchmacher; Oliveira, Lisa; Geller, Mauro

doi:10.4236/pst.2014.21002

Cited by 9 publications

(3 citation statements)

References 15 publications

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“…In the last two decades, many studies concluded the effectiveness and safety of vitamin B and nucleotides (alone or in combination with vitamin B12) in combating neuropathic pain and regeneration of peripheral nerves, but no study was performed in L.R.S. patients [28]. Furthermore, unlike other combinations, PHSD contains vitamin D, with a complex role in the human body.…”

Section: Discussionmentioning

confidence: 99%

“…It has demonstrated the effectiveness of administering medications containing pyrimidine nucleotides (uridine triphosphate -U.T.P., cytidine monophosphate -C.M.P.) in reducing pain intensity associated with diabetic neuropathy, back pain, cervical pain, and trauma-compressive disorders [27], with neuro regenerative properties in the medium term [28]. The use of uridine and cytidine nucleotides associated with hydroxocobalamin had positive control of the intensity of chronic neuropathic low back pain, with a reduction in the consumption of rescue analgesics, thus improving and enhancing the quality of treatment [27,29], and in reducing the pain and improving the motor activity of the patients with alcoholic polyneuropathy [30].…”

Section: Introductionmentioning

confidence: 99%

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Quality of Life in Patients with Lumbosacral Radicular Syndrome and Complete Rehabilitation Program (PRISUM PHSD/1/2022)

2024

J Family Med Prim Care Open Acc

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Worldwide, Lumbosacral Radicular Syndrome (L.R.S.) represents one of the most common lumbar spine problems, inducing disability, reduced quality of life, and working capability. We performed a prospective, double-blind, randomized study in the Departments of Physical Medicine and Rehabilitation, Filantropia Hospital, Craiova, and Techirghiol Balneal and Rehabilitation Sanatorium from June to October 2022. We analyzed the effects of ProHumano+ SpineDinamic (PHSD) on the severity reduction of radicular pain and improvement of quality of life in patients with L.R.S. over three months. A total of 247 patients were randomly divided into two groups: Group 1 (151 patients) received 10 sessions of the rehabilitation program and PHSD (daily, three months), and Group 2 (96 patients) received ten sessions of the rehabilitation program and placebo (daily, three months). Conventional physical therapy (transcutaneous nerve stimulation, ultra-sound, and low-intensity laser treatment) and kinetic program represented the components of a rehabilitation program. Statistical analysis was performed using Microsoft Excel (Microsoft Corp., Redmond, WA, U.S.A.), together with the XLSTAT add-on (Addinsoft SARL, Paris, France). All patients had a favorable evolution, but the difference was significantly statistic for G1 patients. These results concluded that daily PHSD for three months naturally affected clinical and functional status in L.R.S.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients with Lumbosacral Radicular Syndrome and Complete Rehabilitation Program (PRISUM PHSD/1/2022)

2024

J Family Med Prim Care Open Acc

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“…В последующем было проведено двойное слепое рандомизированное сравнительное исследование с участием пациентов с ПБ, БС в области бедра и шеи нетравматического характера [23]. Все больные были рандомизированы на 2 группы: 40 пациентов 1-й группы (группа Д) получали комбинацию препаратов диклофенак-холестирамин 1 раз в сутки, 1,5 мг уридинтрифосфата (УТФ), 2,5 мг цитидинмонофосфата (ЦМФ) и 1 мг гидроксокобаламина 3 раза в сутки; 41 пациент 2-й группы получал 1,5 мг УТФ, 2,5 мг ЦМФ и 1 мг гидроксокобаламина 3 раза в сутки.…”

Section: эффективность витаминов группы в при пероральном назначенииunclassified

Neurotropic effect of B vitamins in the complex treatment of pain syndrome

Shavlovskaya

2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Combined vitamin preparations in therapeutic doses are used, along with simple analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), muscle and epidural blockade, for the relief of acute pain. It is recommended to use the B vitamin preparation neuromultivit. The tablet form of this preparation contains vitamin thiamine hydrochloride (100 mg), pyridoxine hydrochloride (200 mg), cyanocobalamin (0.2 mg), and injectable form includes thiamine hydrochloride (100mg), pyridoxine hydrochloride (100 mg), cyanocobalamin (1 mg). The efficacy of neuromultivit in a two stage scheme (intramuscular injections of 2 ml daily for 5-10 days with further injections 2-3 times a week for 2-3 weeks at the initial stage and 1 tablet 3 times a day for 4 weeks at the second stage) was shown.

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The results of an open observational study on multimodal effects of the efficacy and safety of supplement neurouridine in patients with nonspecific low back pain (MULTINEURO-1)

Yakupov¹,

Troshina²,

Kashapova³

et al. 2020

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin

Cited by 9 publications

References 15 publications

Quality of Life in Patients with Lumbosacral Radicular Syndrome and Complete Rehabilitation Program (PRISUM PHSD/1/2022)

Quality of Life in Patients with Lumbosacral Radicular Syndrome and Complete Rehabilitation Program (PRISUM PHSD/1/2022)

Neurotropic effect of B vitamins in the complex treatment of pain syndrome

The results of an open observational study on multimodal effects of the efficacy and safety of supplement neurouridine in patients with nonspecific low back pain (MULTINEURO-1)

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