Symptomatic Rathke's cleft cyst

Yoshida, Jun; Kobayashi, Tatsuya; Kageyama, Naoki; Kanzaki, Masaki

doi:10.3171/jns.1977.47.3.0451

Cited by 113 publications

(11 citation statements)

References 18 publications

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“…Craniopharyngiomas are derived from remainders of the squamous cells of the craniopharyngeal duct [4]. This almost mutual origin explains the possible mixed forms of Rathke's cleft cyst and craniopharyngioma that were reported by Yoshida et al [5]. Our case had OKUDA et al Table 2.…”

Section: Discussionsupporting

confidence: 50%

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A Boy with Rathke's Cleft Cyst

Okada¹,

Hashimoto²,

Koga³

et al. 1993

Clin Pediatr Endocrinol

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Abstract. We report a 13-year-old boy with Rathke's cleft cyst who had diabetes insipidus (DI), visual disturbance, and GH deficiency. He was admitted to our hospital in 1988 because of polyuria and visual disturbance. He had homonymous hemianopsia and DI; however, the brain computed tomography (CT) was normal. He received 1-deamino-8-D-arginine vasopressin (DDAVP) therapy. In 1989, he was found to have GH deficiency and GH treatment was started. In 1991, a 1.2 cm sized mass was found in the sella area by magnetic resonance imaging (MRI) and removed by microscopic transsphenoidal surgery. Histological examination revealed a Rathke's cleft cyst with craniopharyngioma.In spite of visual disturbance at the first visit, no mass had been found in the brain by CT or MRI during the first two years of GH treatment. However, the mixed form of Rathke's cleft cyst and craniopharyngioma had grown rapidly and was subsequently detected by MRI. He has to be followed up very carefully by MRI for a long period.

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Section: Discussionsupporting

confidence: 50%

“…Small, asymptomatic Rathke's cleft cysts are relatively common, found in 13 to 33% of cases at autopsy [6]. The clinical symptoms of Rathke's cleft cysts are usually the result of a local mass effect [5].…”

Section: Discussionmentioning

confidence: 99%

A Boy with Rathke's Cleft Cyst

Okada¹,

Hashimoto²,

Koga³

et al. 1993

Clin Pediatr Endocrinol

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“…Most RCC are asymptomatic and require no intervention. The first symptomatic RCC was reported by Goldzeiher in 1913 [4].…”

Section: Introductionmentioning

confidence: 97%

Rathke’s cleft cyst presenting as bilateral abducens nerve palsy

et al. 2009

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We present a patient with a Rathke's cleft cyst who presented with rapidly progressive bilateral 6th nerve palsy. A 20-year-old woman with a history of cleft palate, hypertension, and hydronephrotic kidneys presented with a one month history of headache, associated with dizziness and diplopia on horizontal gaze. Examination was significant for profound bilateral 6th nerve palsies. Magnetic resonance imaging showed a hypodense mass that filled the sella and compressed the right cavernous sinus without contacting the optic chiasm. Pituitary function was normal. An endoscopic, transnasal transsphenoidal resection of the lesion was performed; microscopic examination revealed a Rathke's cleft cyst. Surgical excision resulted in near complete resolution of the bilateral 6th nerve palsy. Rathke's cleft cysts are an unusual cause of bilateral sixth nerve palsy and represent a potential cause of cranial neuropathy.

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“…Their cyst walls are composed of epithelial cells and there is fluid with high protein concentration inside the cyst [1,2]. RCCs are found to arise from embryonic remnants of Rathke's pouch and are typically located at the pars intermedia between the adenohypophysis and the neurohypophysis [3,4]. Although they are reported in as many as 3-22% of all autopsy studies, they are seldom symptomatic during life [5,6].…”

Section: Introductionmentioning

confidence: 99%