Symptomatic Respiratory Syncytial Virus Infection in Previously Healthy Young Adults Living in a Crowded Military Environment

O’Shea, Matthew K.; Ryan, Margaret A. K.; Hawksworth, Anthony W.; Alsip, Bryan; Gray, Gregory C.

doi:10.1086/431591

Cited by 60 publications

(61 citation statements)

References 33 publications

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“…The clinical significance of such RSV RNA detection in COPD patients, and whether such RNA represents replication-competent RSV virions remain to be elucidated. More recent studies [25,26] based on RT-PCR provide additional data on the incidence of RSV infection in adults among healthy young persons such as military recruits and those presenting with respiratory illness to the emergency department.…”

Section: Diagnosis Of Respiratory Syncytial Virus Infection In Adultsmentioning

confidence: 99%

Respiratory syncytial virus infection in adults

Murata¹

2008

Current Opinion in Pulmonary Medicine

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Section: Diagnosis Of Respiratory Syncytial Virus Infection In Adultsmentioning

confidence: 99%

Respiratory syncytial virus infection in adults

Murata¹

2008

Current Opinion in Pulmonary Medicine

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“…Not surprisingly, we found rates of ILIs to be 2-16 times higher among the recruits compared to the non-recruits depending on the service, immunization group, analysis cohort, and year of study. Previous studies of the recruit population have reported significant burden of respiratory disease and outbreaks of disease, due primarily to adenovirus, influenza, respiratory syncytial virus, and bacterial infections [14,18,[40][41][42][43]. The high burden and mixing of a variety of respiratory pathogens in this setting may alter the protective effect of vaccines.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the trivalent live attenuated vs. inactivated influenza vaccines among U.S. military service members

Eick¹,

Wang²,

Hughes³

et al. 2009

Vaccine

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“…40 % of infected adults missed work and the average duration of the RSV illness, 10 days, was twice that of acute respiratory infections from other viruses. Among military recruits, RSV is also a major cause of acute respiratory illness and causes ward confinement at rates similar to that of influenza (O'Shea et al 2005). The morbidity and mortality associated with RSV in adults is greatest in those with comorbidities.…”

Section: Burden Of Rsv Disease: Industrialized Countriesmentioning

confidence: 99%

Clinical and Epidemiologic Features of Respiratory Syncytial Virus

Hall

Simões

Anderson

2013

Current Topics in Microbiology and Immunology

129

135

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Since its discovery in 1955, respiratory syncytial virus (RSV) has consistently been noted to be the single most important cause of lower respiratory tract illness in infants <1 year of age. RSV also causes repeat infections and significant disease throughout life. In addition to the young child, persons with compromised immune, pulmonary or cardiac systems, and the elderly have significant risk from infection. Though RSV causes the full spectrum of acute respiratory illnesses, it is most notably associated with signs and symptoms of increased airway resistance manifested as wheezing and, in the young child, diagnosed as bronchiolitis. In temperate climates, RSV occurs as yearly outbreaks usually between late fall and early spring lasting 3-4 months in a community. The timing of outbreaks varies between years and in the same year between regions and even between nearby communities. RSV can be a serious nosocomial pathogen in high risk individuals but nosocomial transmission that can often be prevented with meticulous attention to good infection control practices. High risk groups include the premature infants and persons of any age with compromised cardiac, pulmonary, or immune systems. Risk factors for infection include increased number of children in the household and day care center attendance. There are reasonable estimates of the sizable burden of RSV disease in infants and young children and the elderly but less data on disease in older children, the role of RSV in later reactive airway disease (see chapter by M.T. Lotz et al. , this volume), and RSV-associated mortality in developing countries. The available data on burden of disease suggests there are at least four potential target populations for a vaccine, the young infant, young children >4-6 months of age, pregnant women, and the elderly. A link between infection in the young infant and later reactive airway disease and mortality in developing countries is needed. Each target population has different vaccine safety and efficacy concerns and may warrant a different type of vaccine.

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Symptomatic Respiratory Syncytial Virus Infection in Previously Healthy Young Adults Living in a Crowded Military Environment

Cited by 60 publications

References 33 publications

Respiratory syncytial virus infection in adults

Respiratory syncytial virus infection in adults

Comparison of the trivalent live attenuated vs. inactivated influenza vaccines among U.S. military service members

Clinical and Epidemiologic Features of Respiratory Syncytial Virus

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