Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis

Yagi, Minami; Tanaka, Atsushi; Abe, Masanori; Namisaki, Tadashi; Yoshiji, Hitoshi; Takahashi, Atsushi; Ohira, Hiromasa; Komori, Atsumasa; Yamagiwa, Satoshi; Kikuchi, Kentaro; Tetsuya, Yasunaka; Takaki, Akinobu; Ueno, Yoshiyuki; Honda, Akira; Matsuzaki, Yasushi; Takikawa, Hajime

doi:10.1038/s41598-018-31063-8

Cited by 22 publications

(27 citation statements)

References 31 publications

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“…Inflammation is associated with decreased levels of albumin which may partly rebut the theory of an inflammatory aetiology of uraemic itch . Interestingly, a lower serum albumin was associated with itch scores in Japanese patients with biliary cholangitis …”

Section: Discussionsupporting

confidence: 91%

The course of chronic itch in hemodialysis patients: results of a 4‐year follow‐up study of GEHIS (German Epidemiological Hemodialysis Itch Study)

Plewig

Ofenloch

Mettang³

et al. 2019

Acad Dermatol Venereol

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Background Chronic itch (CI) is a frequent symptom in hemodialysis (HD) patients. Previous studies demonstrated great impairments of general well‐being and health‐related quality of life (HRQOL) as well as a higher mortality in those suffering from CI. Objective The German Epidemiological Hemodialysis Itch Study (GEHIS) is a representative cohort of HD patients in Germany. All patients were followed up 4 years later. The current analyses present data on the course of CI in HD patients, its associated factors including comorbidities, laboratory values and HRQOL. Methods We assessed sociodemographic data, routine laboratory values, comorbidities, HRQOL (SF‐12), depression and anxiety (HADS), sleep (duration and quality) and in those suffering from CI characteristics, intensity of CI and itch‐related quality of life (ItchyQoL). Those with CI were offered a dermatological examination and CI was classified according to the IFSI classification. Patients were asked if they had consulted a physician about CI. Results Of the patients who had suffered from CI in 2013 (n = 234), 90.5% (212) patients could be followed up. About 36.3% (n = 85) had died, 9.8% (n = 23) had received a kidney transplant in the meantime. A total of 52 HD patients still suffered from CI, in 52 CI had stopped. Those patients still suffering from CI (n = 52) reported a higher mean itch intensity, lower ItchyQoL, higher levels of anxiety and a lower mean sleeping time in 2013. On the other hand, those who did not suffer from CI anymore showed a significant increase of HRQOL compared to 2013. There was no significant difference in dialysis characteristics and laboratory values except for albumin. Only a minority of patients in HD had consulted a dermatologist because of CI (29.9%). Conclusion Our data demonstrate that CI is a persisting symptom in 50% of the HD patients and when it disappears HRQOL recovers. We confirm that CI is a disregarded symptom in HD patients.

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Section: Discussionsupporting

confidence: 91%

The course of chronic itch in hemodialysis patients: results of a 4‐year follow‐up study of GEHIS (German Epidemiological Hemodialysis Itch Study)

Plewig

Ofenloch

Mettang³

et al. 2019

Acad Dermatol Venereol

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“…In PSC, no medical treatment has been shown to be effective in the improvement of LT‐free survival . Furthermore, even if responses to treatment are excellent, patients with AILD frequently experience a variety of physical symptoms and psychological problems such as fatigue, pruritus, abdominal pain, and psychological anxiety, significantly reducing health‐related quality of life …”

Section: Introductionmentioning

confidence: 99%

“…3 Furthermore, even if responses to treatment are excellent, patients with AILD frequently experience a variety of physical symptoms and psychological problems such as fatigue, pruritus, abdominal pain, and psychological anxiety, significantly reducing health-related quality of life. [4][5][6][7][8] Estimation of prevalence of AILDs is critical to assess the burden of these diseases on public health. A number of epidemiological studies have been undertaken for AIH, [9][10][11][12][13][14][15][16][17][18][19] PBC, 13,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] and PSC [37][38][39][40][41][42][43] worldwide, and have shown that prevalence significantly varies depending on regions and ethnicities.…”

Section: Introductionmentioning

confidence: 99%

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Tanaka

Mori

Matsumoto

et al. 2019

Hepatology Research

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Aim Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) impose a significant burden on public health, and it is important to estimate their prevalence. We carried out a nationwide, hospital‐based, epidemiological survey of AIH, PBC, and PSC, and compared the results with those from previous surveys. Method We randomly selected health‐care facilities used in the survey from a list of all facilities in Japan. The selection rate was determined according to a stratification based on the facility characteristics and scale. We sent questionnaires to the selected facilities enquiring about the number and sex of patients with AILD who visited the facility in 2016. An identical survey was undertaken for AIH/PBC in 2004 and for PSC in 2007; we carried out a comparative analysis of these data. Results We selected 1793 departments from health centers all over Japan. Of them, 1078 (60.1%) responded to the questionnaires. The number of reported patients with AIH, PBC, and PSC was 8505, 10 847, and 906, respectively, and point prevalence was 23.9 (95% confidence interval, 23.3–24.5) for AIH (8.7 in 2004), 33.8 (33.0–34.6) for PBC (11.6 in 2004), and 1.80 (1.75–1.85) for PSC (0.95 in 2007) per 100 000 population. Male‐to‐female patient ratio of AILD was 1:4.3 for AIH (1:6.9 in 2004), 1:3.9 for PBC (1:7.1 in 2004), and 1:0.88 for PSC (1:1.4 in 2007). Conclusion The current study indicates an increasing trend of prevalence as well as male‐to‐female patient ratio of AILD in Japan.

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“…Health-related quality of life (HRQoL) is an academic discipline, and it has become a fast-growing medical discipline widely accepted by governments, agencies, and public health departments [1,2].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Patients with Primary Biliary Cholangitis: A Single-Center Experience in Serbia

Milovanović¹,

Popović²,

Lalosevic³

et al. 2020

Dig Dis

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Background: Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune disease, predominantly affecting middle-aged women, which may progress to end-stage liver disease. We aimed to assess the quality of life (QoL) in patients with PBC given that social, economic, and geographical factor also influence QoL. Methods: This study included patients with diagnosed PBC according to the European Association for the Study of the Liver guidelines, who were treated for at least 6 months in order to allow adequate time for the initial burden of symptoms to subside. We used the PBC-40 questionnaire validated in the Serbian language. Results: The mean total PBC-40 score was 89.4 ± 29.3. The overall frequency of moderate and severe involvement in each domain was as follows: 84.9% (n = 107) in “Symptoms,” 29.3% (n = 36) in “Itch,” 76.4% (n = 97) in “Fatigue,” 58.1% (n = 72) in “Cognitive,” 77.2% (n = 98) in “Social,” and 70.9% (n = 90) in “Emotional.” There was a statistically significant negative correlation of disease duration and albumin score with the Emotional domain score. Furthermore, this domain showed a significant positive correlation with the Mayo score. Conclusion: The present study demonstrates that patients with PBC have significant impairment in QoL with fatigue being the most prevalent symptom. The Social and Emotional domains were also significantly affected in these individuals, particularly in patients with peripheral edema who exhibited worse QoL that those who were euvolemic.

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Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis

Cited by 22 publications

References 31 publications

The course of chronic itch in hemodialysis patients: results of a 4‐year follow‐up study of GEHIS (German Epidemiological Hemodialysis Itch Study)

The course of chronic itch in hemodialysis patients: results of a 4‐year follow‐up study of GEHIS (German Epidemiological Hemodialysis Itch Study)

Increase trend in the prevalence and male‐to‐female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan

Quality of Life in Patients with Primary Biliary Cholangitis: A Single-Center Experience in Serbia

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