Symptoms and Signs Referable to the Basal Ganglia in Brain Tumor

Sciarra, D; Sprofkin, Bertram E.

doi:10.1001/archneurpsyc.1953.02320280038004

Cited by 30 publications

(7 citation statements)

References 7 publications

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“…In 1953 Sciarra and Sprofkin found an incidence of 2.1% in patients with cerebral tumors. 15 In 1966 Tolosa et al reported a frequency of 1%. 2 The occurrence of such movement disorders is less frequent in contemporary studies.…”

Section: Discussionmentioning

confidence: 99%

Parkinsonism in children resulting from mesencephalic tumors

Pohle

Krauss

1999

Mov. Disord.

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Section: Discussionmentioning

confidence: 99%

Parkinsonism in children resulting from mesencephalic tumors

Pohle

Krauss

1999

Mov. Disord.

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“…The overall outcome of the MD at the last follow up, without respect to therapeutic strategies, was as follows: hemichorea and hemichorea/ballismus disappeared in three patients (cases 4, 12, 13); myoclonus disappeared in one (case 17); tremor disappeared in three patients (cases 1,18,20), improved to some degree in five (cases 3,8,9,11,14), fluctuated in one (case 6), and did not change in two (cases 2, 5); hemidystonia improved to some degree in three patients (cases 7,17,19), fluctuated in one (case 2), did not change in one (case 8), and worsened in two (cases 10, 13). In patient 14 with a grade II astrocytoma of the right thalamus extending to the midbrain, contralateral tremor improved two years after interstitial radio- Figure 2 Axial enhanced CT scans ofpatient 19, 14 years after interstitial radiotherapy with '92Ir.…”

Section: Outcome In Relation To Type Of Movement Disordermentioning

confidence: 99%

Evaluation of the effect of treatment on movement disorders in astrocytomas of the basal ganglia and the thalamus.

Krauss

Braus

Mohadjer

et al. 1993

Journal of Neurology, Neurosurgery & Psychiatry

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Twenty patients with movement disorders associated with astrocytomas (grade I-IV according to the WHO tumour classification) of the basal ganglia and the thalamus were evaluated for the effects of treatment. Five patients had more than one movement disorder when the histological diagnosis was verified by stereotactic biopsy. Twelve had tremors, eight hemidystonia, three hemichorea, and one hemichorea/ballismus, and myoclonus respectively. Ten patients died during the follow up period, and for the surviving patients foilow up periods ranged from 6-21 years. The movement disorders changed over long periods of time related to therapeutic interventions. CSF shunt operations and percutaneous radiotherapy had no definite effect on the movement disorders. There was a moderate response to medical treatment in a few patients. Stereotactic aspiration of tumour cysts had a marked influence on the movement disorder in two patients, and functional stereotactic surgery abolished tumour induced tremor in one. Interstitial radiotherapy was performed in fifteen patients for treatment of the underlying neoplasm and resulted in different and variable alterations of the movement disorders. These differences may be explained by complex interactions involving structures affected primarily by the tumour, as weli as by secondary functional lesions of adjacent structures. ( Neurol Neurosurg Psychiatry 1993;56: 1113-1118 Movement disorders (MDs) in tumours of the basal ganglia and the thalamus have been described within a range from 1-9% in recent studies and from 4-33% in earlier ones.1-5The further course following treatment has been documented only rarely in patients with MDs due to basal ganglia and thalamic astrocytomas.620 This study deals with the clinical course and the change and outcome of MDs in relation to treatment of either the tumour responsible for them or of the symptomatic MDs themselves in twenty patients with basal ganglia and thalamic astrocytomas grade I-IV presenting with MDs at the time of biopsy. Methods A total of 225 patients had astrocytomas grades I-IV of the basal ganglia or the thalamus confirmed histologically by stereotactic biopsy between 1965-86 in the department of stereotaxy. Twenty were identified as having an MD at the time of biopsy.5 The patients were followed up and examined at various times with recent follow ups in 1989, 90 or 91. No follow up data concerning the tremor in patient 16 could be obtained. Some patients had serial film recordings over the years. Most of the long term surviving patients returned at regular intervals for control CT scans. In addition, the relatives, attending physicians and neurologists were interviewed to compile the data.Stereotactic biopsy was performed under local anaesthesia, except in the younger children. Tumour site, volume and the irradiation dosimetry were determined from CT data available since 1975. The RiechertMundinger stereotactic device in the computer-compatible version was used for stereotactic biopsy, interstitial implantation of radioactiv...

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“…The clinical presentation of PCNSL with movement disorders such as myoclonus, tic, chorea, or tremor uncommon. Sciarra and Sprofkin (1953) reported that 2.1% of patients with Parkinsonism had cerebral tumors and Tolosa and Vilato (1965) reported a frequency of 1%. Most of tumors which result in Parkinsonism involve the basal ganglia (Pramstaller et al 1999), supplementary motor area (Haussermann et al 2001), corpus callousm (Sánchez-Guerra et al 2001), or frontal lobe (Bucciarelli and Cavaliere 1991;Krauss et al 1995).…”

Section: Discussionmentioning

confidence: 99%