Symptoms of colorectal cancer contributes to its localization and advancement

Abstract

<b>Introduction:</b> Colorectal cancer is one of the most common cancers occurring in Poland. Unfortunately, this cancer is most often diagnosed at the time of great advancement. This is caused by the appearance of specific symptoms only in the late stages of cancer. Also, such low detection of early stages of adenocarcinoma may be caused by disregarding of slight symptoms. <br/>Purpose:</b> To analyse symptoms in patients with colorectal cancer and correlate with chosen clinical-pathological parameters. <br/>Materials and methods:</b> The study group consisted of 46 patients diagnosed with colorectal cancer. Information on symptoms associated with cancer (subjective and objective) have been selected from patients' medical history. The presence of these symptoms was correlated with the age and sex of patients, tumor location, histological type of cancer, grade of histological malignancy (G), stage of tumor (T stage), presence of lymph node metastases and distant metastases. <br/><b>Results:</b> It has been shown that the presence of pain complaints described by the patient are associated with the occurrence of cancer in the colon. The painfulness and pathological resistance diagnosed by the physician are more often associated with cancer located in the colon. In the case of tumors located in the rectum, faecal admixtures appear more frequently. It has also been shown that the presence of admixtures of blood and mucus in the stool is associated with more advanced local tumors, infiltrating pericolorectal tissues (T3 + T4). <br/><b>Conclusions:</b> Familiarity with clinical symptoms of colorectal cancer could make patients more sensitive to more often screening for cancer. Analysis of these symptoms could indicate to the physician the location or stage of the cancer.

Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase

“…The World Health Organization (WHO) estimates that the numbers of patients with CRC and CRC-related deaths will increase by 77 and 80% by 2030 [ 2 ]. The high mortality rate of CRC patients results from late diagnosis, which is due to the lack of clear physical symptoms at early stages [ 3 ]. Early resection, as permitted by early detection, is optimal CRC treatment.…”

Knowledge, Attitudes, and Practices Related to Colorectal Cancer's Prevention and Early Detection Among Older Adults in Kuwait: A Cross-Sectional Study

“…Various factors, including the cancer site, size, and stage, influence the symptoms of CRC [ 7 ]. Bleeding and altered bowel habits are the most frequent, with pain and bowel obstruction also common [ 7 - 10 ].…”

“…Various factors, including the cancer site, size, and stage, influence the symptoms of CRC [ 7 ]. Bleeding and altered bowel habits are the most frequent, with pain and bowel obstruction also common [ 7 - 10 ]. These symptoms can vary based on the location and stage of the cancer, with pain being more associated with colon cancer and fecal admixtures with rectal cancer [ 7 ].…”

Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway

“…The incidence of breast cancer is increasing rapidly [1]. Of all cancers in women, breast cancer has the highest incidence rate and highest mortality rate [2]. Cancer remains a cause for concern despite the increase in physical and chemical therapies, and there are still many barriers to the treatment of breast cancer, such as adverse effects, arising from radiotherapy, surgery, and chemotherapy/hormonotherapy [3].…”

“…In the current study, we found in a screening test that the MeOH extract of L. cuneata exerted inhibitory effect on metabolic activity in MCF-7 human breast cancer cells, which led us to perform further phytochemical analysis and identify the bioactive compound(s) responsible for these effects. Bioassay-guided fractionation and chemical investigation of the MeOH extract led to the isolation of nine compounds (four lignan glycosides (1)(2)(3)(4), three flavonoid glycosides (5)(6)(7), and two phenolic compounds (8 and 9)). The structures of the isolated compounds were identified by LC-MS analysis and their spectroscopic data and physical data were compared with previously reported values.…”