Symptoms of gastro‐oesophageal reflux disease and the severity of obstructive sleep apnoea syndrome are not related in sleep disorders center patients

Kim, H.-N.; Vorona, Robert Daniel; Winn, M. P.; Doviak, Michael; Johnson, David A.; Ware, J. Catesby

doi:10.1111/j.1365-2036.2005.02447.x

Cited by 53 publications

(36 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, we found no association between AHI or ArI and severity of nocturnal GER which would be expected if obstructive respiratory events were precipitating nocturnal GER events. These findings are consistent with some, but not all, previous studies [37,38]. The only studies that have reported a relationship between AHI and severity of GER have used symptoms [12] or endoscopic findings [39] to define GER severity, rather than pH monitoring, as was used in the present study.…”

Section: Mechanism Of Nocturnal Ger In Osasupporting

confidence: 94%

Mechanisms of nocturnal gastroesophageal reflux events in obstructive sleep apnea

et al. 2010

View full text Add to dashboard Cite

Upper airway obstructive and nocturnal GER events are not directly related. The relatively low P (b) in these OSA patients raises the possibility of weakening of the gastroesophageal junction from repetitive strain associated with obstructed breathing events. The favourable effect of CPAP on nocturnal GER is possibly due to an increase in nadir P (b) and decrease in the duration for which the LES relaxes during swallow-induced and transient LESR.

show abstract

Section: Mechanism Of Nocturnal Ger In Osasupporting

confidence: 94%

Mechanisms of nocturnal gastroesophageal reflux events in obstructive sleep apnea

et al. 2010

View full text Add to dashboard Cite

show abstract

“…This is consistent with fi ndings of multiple studies in the past which showed lack of association between overall AHI and nGER severity. [16][17][18] The most recent study by Shepherd and Orr reported such fi nding by documenting the nGER by esophageal pH monitoring during polysomnography and suggested that obesity rather than AHI may have a greater role in the relationship between OSA and nGER. 17 This prompted us to perform further subgroup analyses, which revealed that the BMI of our patients with moderate-severe OSA (mean = 34.17 kg/m 2 ) was much higher than those with mild OSA (mean = 28.98 kg/m 2 ).…”

Section: Discussionmentioning

confidence: 98%

Effect of CPAP Therapy on Symptoms of Nocturnal Gastroesophageal Reflux among Patients with Obstructive Sleep Apnea

Tamanna

Campbell

Warren

et al. 2016

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Study Objectives: Nocturnal gastroesophageal reflux (nGER) is common among patients with obstructive sleep apnea (OSA). Previous studies demonstrated that continuous positive airway pressure (CPAP) reduces symptoms of nGER. However, improvement in nGER symptoms based on objective CPAP compliance has not been documented. We have examined the polysomnographic characteristics of patients with nGER and OSA and looked for association of OSA severity and CPAP compliance with improvement in nGER symptoms. Methods: We interviewed 85 veterans with OSA to assess their daytime sleepiness (Epworth Sleepiness scale [ESS]) and nGER symptom frequency after their polysomnography and polysomnographic data were reviewed. At 6 months' follow-up, ESS score, nGER score, and CPAP machine compliance data were reassessed. Data from 6 subjects were dropped from final analysis due to their initiation of new medication for nGER symptom since the initial evaluation. Results: Sixty-two of 79 (78%) patients complained of nGER symptoms during initial visit. At baseline, nGER score was correlated with sleep efficiency (r = 0.43), and BMI correlated with the severity of OSA (r = 0.41). ESS and nGER improved (p < 0.0001) in all patients after 6 months, but more significantly in CPAP compliant patients. A minimum CPAP compliance of 25% was needed to achieve any benefit in nGER improvement. Conclusions: Nocturnal gastroesophageal reflux is common among patients with OSA which increases sleep disruption and worsens the symptoms of daytime sleepiness. CPAP therapy may help improve the symptoms of both nocturnal acid reflux and daytime sleepiness, but adherence to CPAP is crucial to achieve this benefit. Keywords: OSA, obstructive sleep apnea, GERD, nocturnal reflux, CPAP Citation: Tamanna S, Campbell D, Warren R, Ullah MI. Effect of CPAP therapy on symptoms of nocturnal gastroesophageal reflux among patients with obstructive sleep apnea.

show abstract

“…Whilst most of the aforementioned studies did not control for sleep apnea, several recent studies have suggested that sleep apnea is not the underlying cause for GERD [51,52]. GERD and sleep apnea are two common disorders that share similar risk factors and thus may coexist in the same subject.…”

Section: Sleep Apneamentioning

confidence: 95%

The Pathophysiological Mechanisms of GERD in the Obese Patient

Fass

2008

Dig Dis Sci

View full text Add to dashboard Cite

Obesity has increased dramatically in the last 30 years, affecting 33% of the adult population in the United States. Increase in body mass index has been shown to be associated with the increase in the prevalence of gastroesophageal reflux disease (GERD) symptoms, esophageal mucosal injury, and GERD complications. The putative mechanisms responsible for the close relationship between GERD and increased body mass index include increased intragastric pressure, increased gastroesophageal pressure gradient, esophageal motor and sensory abnormalities, increase in prevalence of hiatal hernia, increase in serum female hormonal levels, diet, and increase in comorbidities. Whilst the current efforts are to focus on one major underlying mechanism, it is highly likely that multiple factors contribute to the increased prevalence of GERD in the obese patient.

show abstract

Symptoms of gastro‐oesophageal reflux disease and the severity of obstructive sleep apnoea syndrome are not related in sleep disorders center patients

Cited by 53 publications

References 30 publications

Mechanisms of nocturnal gastroesophageal reflux events in obstructive sleep apnea

Mechanisms of nocturnal gastroesophageal reflux events in obstructive sleep apnea

Effect of CPAP Therapy on Symptoms of Nocturnal Gastroesophageal Reflux among Patients with Obstructive Sleep Apnea

The Pathophysiological Mechanisms of GERD in the Obese Patient

Contact Info

Product

Resources

About