Synaptic facilitation requires paired activation of convergent pathways in the neocortex

Baranyi, Attila; Fehér, O.

doi:10.1038/290413a0

Cited by 104 publications

(30 citation statements)

References 21 publications

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“…3, B and C, qualitatively agree with past electrophysiological results that suggest short microstimulation produces complex and long-lasting effects on cortical networks (Berman et al 1991;Butovas and Schwarz 2003;Butovas et al 2006;Chung and Ferster 1998;Contreras et al 1997;Burkhalter 1996, 1999). We next wanted to further explore the link between our behavioral data, and these other studies by modeling the effect of microstimulation on MT activity that would account for our experimental observations.…”

Section: Modeling the Time Course Of A Single Microstimulation Pulsesupporting

confidence: 80%

“…Several studies have previously examined the temporal spread of microstimulation on cortical activity, both in vitro Burkhalter 1996, 1999) and in anesthetized, in vivo preparations (Berman et al 1991;Butovas and Schwarz 2003;Butovas et al 2006;Chung and Ferster 1998;Contreras et al 1997). These studies showed that microstimulation induced long-lasting suppression in neural activity, potentially mediated by GABA B receptor synaptic inhibition (Butovas et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to these behavioral studies, neural activity measured in response to microstimulation in both in vitro and in vivo preparations has usually been characterized as a short excitatory response followed by a long period of inhibition (Berman et al 1991;Butovas and Schwarz 2003;Butovas et al 2006;Chung and Ferster 1998;Contreras et al 1997;Burkhalter 1996, 1999). Thus microstimulation can produce a "temporal spread" of neural activity that is fundamentally different from normal neurophysiological responses.…”

Section: Introductionmentioning

confidence: 99%

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Behavioral Time Course of Microstimulation in Cortical Area MT

Masse

Cook

2010

Journal of Neurophysiology

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Masse NY, Cook EP. Behavioral time course of microstimulation in cortical area MT. J Neurophysiol 103: 334 -345, 2010. First published October 28, 2009 doi:10.1152/jn.91022.2008. Electrical stimulation of the brain is a valuable research tool and has shown therapeutic promise in the development of new sensory neural prosthetics. Despite its widespread use, we still do not fully understand how current passed through a microelectrode interacts with functioning neural circuits. Past behavioral studies have suggested that weak electrical stimulation (referred to as microstimulation) of sensory areas of cortex produces percepts that are similar to those generated by normal sensory stimuli. In contrast, electrophysiological studies using in vitro or anesthetized preparations have shown that neural activity produced by brief microstimulation is radically different and longer lasting than normal responses. To help reconcile these two aspects of microstimulation, we examined the temporal properties that microstimulation has on visual perception. We found that brief application of subthreshold microstimulation in the middle temporal (MT) area of visual cortex produced smaller and longer-lasting effects on motion perception compared with an equivalent visual stimulus. In agreement with past electrophysiological studies, a computer simulation reproduced our behavioral effects when the time course of a single microstimulation pulse was modeled with three components: an immediate fast strong excitatory component, followed by a weaker inhibitory component, and then followed by a long duration weak excitatory component. Overall, these results suggest the behavioral effects of microstimulation in our experiments were caused by the unique and long-lasting temporal effects microstimulation has on functioning cortical circuits. I N T R O D U C T I O NElectrical microstimulation of the brain is an important research tool for establishing causality between neural activity and behavior (for reviews, see Cohen and Newsome 2004;Romo and Salinas 1999) and serves as the basis for supplying sensory inputs in neural prosthetics (Bradley et al. 2005;Fernandez et al. 2005;Girvin 1988;McIntyre and Grill 2000;Middlebrooks et al. 2005;Normann et al. 1999;Tehovnik and Slocum 2007;Troyk et al. 2003). Both of these applications rely on the assumption that microstimulation can generate percepts that are reasonably similar to those produced by naturally occurring stimuli.Many past behavioral studies suggest that microstimulation of cortical sensory areas is equivalent to natural inputs in its ability to influence sensory perception (Bisley et al. 2001;Carey et al. 2005;Celebrini and Newsome 1995;de Lafuente and Romo 2005;DeAngelis and Newsome 2004;Ditterich et al. 2003;Hanks et al. 2006;Liu and Newsome 2005;Murasugi et al. 1993;Nichols and Newsome 2002;Romo et al. 1998Romo et al. , 2000Salzman et al. 1990Salzman et al. , 1992Uka and DeAngelis 2006). In these experiments, however, microstimulation was usually applied for hundreds of milliseconds to s...

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Section: Modeling the Time Course Of A Single Microstimulation Pulsesupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Behavioral Time Course of Microstimulation in Cortical Area MT

Masse

Cook

2010

Journal of Neurophysiology

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“…The PAS-induced changes in MEP amplitude last at least 60 min, are input specific, and are blocked by an NMDA receptor antagonist (Stefan et al, 2000(Stefan et al, , 2002Ridding and Taylor, 2001;Wolters et al, 2003). These characteristics are consistent with the properties of LTP/D as defined in recordings from single neurons or populations of neurons in slice preparations of animal M1 (Baranyi and Feher, 1981;Hess and Donoghue, 1994;Castro-Alamancos et al, 1995;. According to these similarities, the term associative LTP/D-like plasticity was introduced to refer to the PAS-induced changes in MEP amplitude in the human studies (Stefan et al, 2000;Wolters et al, 2003).…”

Section: Discussionsupporting

confidence: 59%

Learning Modifies Subsequent Induction of Long-Term Potentiation-Like and Long-Term Depression-Like Plasticity in Human Motor Cortex

Ziemann¹,

Iliać²,

Pauli³

et al. 2004

J. Neurosci.

531

484

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“…In contrast, a Hebbian stimulation protocol mimics the synchronization of cortical inputs, from the same or different cortical areas, leading thus to a suprathreshold depolarization of SONs. Studies performed in other brain structures report that non-Hebbian protocols either fail (Baranyi and Fehér, 1981;Gustafsson et al, 1987) or induce plasticity with lower magnitude than Hebbian protocols (Alonso et al, 1990;Urban and Barrionuevo, 1996). Therefore, we investigated whether LTP and LTD induced by Hebbian protocols displayed larger synaptic efficacy changes than those induced by non-Hebbian protocols.…”

mentioning

confidence: 99%

Bidirectional Activity-Dependent Plasticity at Corticostriatal Synapses

Fino¹,

Głowiński²,

Venance³

2005

J. Neurosci.

223

267

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Corticostriatal projections originate from the entire cerebral cortex and provide the major source of glutamatergic inputs to the basal ganglia. Despite the importance of corticostriatal connections in sensorimotor learning and cognitive functions, plasticity forms at these synapses remain strongly debated. Using a corticostriatal slice preserving the connections between the somatosensory cortex and the target striatal cells, we report the induction of both non-Hebbian and Hebbian forms of long-term potentiation (LTP) and long-term depression (LTD) on striatal output neurons (SONs). LTP and LTD can be induced selectively by different stimulation patterns (highfrequency trains vs low-frequency pulses) and were evoked with similar efficiency in non-Hebbian and Hebbian modes. Combination of LTP-LTD and LTD-LTP sequences revealed that bidirectional plasticity occurs at the same SONs and provides efficient homeostatic mechanisms leading to a resetting of corticostriatal synapses avoiding synaptic saturation. The effect of temporal relationship between cortical stimulation and SON activity was assessed using spike-timing-dependent plasticity (STDP) protocols. An LTP was observed when an action potential was triggered in the striatal neuron before the cortical stimulus, and, conversely, an LTD was induced when the striatal neuron discharge was triggered after the cortical stimulation. Such STDP was reversed when compared with those described so far in other mammalian brain structures. This mechanism may be essential for the role of the striatum in learning of motor sequences in which sensory and motor events are associated in a precise time sequence.

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Synaptic facilitation requires paired activation of convergent pathways in the neocortex

Cited by 104 publications

References 21 publications

Behavioral Time Course of Microstimulation in Cortical Area MT

Behavioral Time Course of Microstimulation in Cortical Area MT

Learning Modifies Subsequent Induction of Long-Term Potentiation-Like and Long-Term Depression-Like Plasticity in Human Motor Cortex

Bidirectional Activity-Dependent Plasticity at Corticostriatal Synapses

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