Synaptic organization of tonic motor units in vertebrates

Гришин, С. Н.; Зиганшин, А. У.

doi:10.1134/s1990747814060014

Cited by 7 publications

(2 citation statements)

References 50 publications

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“…The article focused on the phasic muscles, and one should not forget about the various effects of purines in tonic motor units [ 104 ], data about which were only touched on in this review and require separate publication. As for the predominance of attention in the article to one purine, ATP, this is primarily to correct historical injustice, when for decades its own synaptic effects have not been fully recognized, giving exceptional preference to its metabolite—adenosine [ 105 ].…”

Section: Discussionmentioning

confidence: 99%

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Зиганшин

Khairullin

Hoyle

et al. 2020

IJMS

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A review of the data on the modulatory action of adenosine 5’-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission is presented. The effects of these endogenous modulators on pre- and post-synaptic processes are discussed. The contribution of purines to the processes of quantal and non-quantal secretion of acetylcholine into the synaptic cleft, as well as the influence of the postsynaptic effects of ATP and adenosine on the functioning of cholinergic receptors, are evaluated. As usual, the P2-receptor-mediated influence is minimal under physiological conditions, but it becomes very important in some pathophysiological situations such as hypothermia, stress, or ischemia. There are some data demonstrating the same in neuromuscular transmission. It is suggested that the role of endogenous purines is primarily to provide a safety factor for the efficiency of cholinergic neuromuscular transmission.

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Section: Discussionmentioning

confidence: 99%

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Зиганшин

Khairullin

Hoyle

et al. 2020

IJMS

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“…At the same time, the above studies did not attach special importance to the types of skeletal muscle examined. It is known that several types of phase skeletal muscle fibers are distinguished from which "slow" and "fast" are distinguished in all classifications [47,48]. It is understandable that these muscles differing in their very function-maintaining pose ("slow" muscles) and performing subtle movements ("fast")-are made to react differently to temperature changes which is observed in practice [49][50][51].…”

Section: Rodent Skeletal Musclesmentioning

confidence: 99%

Temperature-Dependent Effects of ATP on Smooth and Skeletal Muscles

Зиганшин¹,

Гришин²

2019

Adenosine Triphosphate in Health and Disease

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ATP acting via different subtypes of P2X and P2Y receptors induces contractions or relaxation of mammalian smooth muscles, while in skeletal muscles, ATP can pre-and postsynaptically modulate effect of acetylcholine. It was shown that effects of ATP on both types of the muscle are significantly changed when the temperature shifts from physiological condition. For example, contractile responses of rodent urinary bladder and vas deferens mediated by P2X receptors are markedly increased with the decrease of the temperature. Similarly, in frog skeletal muscles, ATP-induced inhibition of acetylcholine release became more pronounced at low temperatures. In case of mammalian skeletal muscle, effect of temperature on ATPinduced responses depends on the type of muscle-slow and fast. In this chapter, we will discuss temperature-dependent effects of ATP on different muscle contractility and their possible mechanisms.

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Neuromuscular transmission in Ca2+-free extracellular solution

Гришин

2016

Biochem. Moscow Suppl. Ser. A

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Synaptic organization of tonic motor units in vertebrates

Cited by 7 publications

References 50 publications

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Temperature-Dependent Effects of ATP on Smooth and Skeletal Muscles

Neuromuscular transmission in Ca2+-free extracellular solution

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