Synaptonemal complex analysis of an X-autosome translocation-carrier in the domestic pig

Villagomez, Daf; Świtoński, M.; Singh, B. N.; Fisher, K S; Gustavsson, I.; Basrur, P.K.

doi:10.1186/1297-9686-23-s1-s222

Cited by 7 publications

(2 citation statements)

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“…In pigs, there are only 2 documented cases of an X-autosome reciprocal translocation as well as 2 cases of a Y-autosome reciprocal translocation [Gustavsson et al, 1989;Villagómez et al, 1991;Singh et al, 1994;Pinton et al, 2008;Barasc et al, 2012]. In humans, Y-autosome translocations are expected at a rate of 1/2,000, thus more than 100 cases are already documented [Nielsen and Rassmussen, 1976;Brisset, 2005].…”

Section: Discussionmentioning

confidence: 99%

Azoospermia and Testicular Hypoplasia in a Boar Carrier of a Novel Y-Autosome Translocation

Villagómez

Révay

Donaldson

et al. 2016

Sex Dev

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Few sex-autosome chromosome abnormalities have been documented in domestic animal species. In humans, Y-autosome chromosome abnormalities may occur at a rate of 1/2,000 live births, whereas in the domestic pig only 2 Y-autosome reciprocal translocations have been previously described. During a routine cytogenetic screening of young boars, we identified a new Y-autosome translocation carrier, which after puberty showed semen devoid of sperm and testicular hypoplasia with spermatogenesis arrest. Whole chromosome painting by FISH analysis corroborated the reciprocal nature of the chromosomal exchanges between the Y chromosome and SSC13. The possible causes for the observed meiotic arrest of the carrier are reviewed.

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Section: Discussionmentioning

confidence: 99%

Azoospermia and Testicular Hypoplasia in a Boar Carrier of a Novel Y-Autosome Translocation

Villagómez

Révay

Donaldson

et al. 2016

Sex Dev

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“…In cases involving translocations between autosomes, litter sizes have been found to be 30–50% smaller and in cases where the rearrangements have involved sex chromosomes and autosomes, the animals may have been completely sterile (G ustavsson et al 1989; V illagomez et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Two cases of reciprocal translocations in domestic pigs producing small litters

Mäkinen

Pitkänen

Andersson

1997

J Animal Breeding Genetics

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Two boars of Finnish Yorkshire breed were selected for chromosomal analysis because of their small litters. One had a complex three breakpoint reciprocal translocation where the small distal chromosome segments were fused in new combinations between autosomes 2,9 and 14. This boar with a 2n = 38,XY,t(2;9;14)(q23;q22;q25) karyotype had produced approximately 3.3 piglets per litter and its fertility was reduced by 70% compared to average of litter size in Finnish Yorkshire breed pigs. In another Finnish Yorkshire breed boar, the long arm of autosome 7 had broken and attached to the terminal end of autosome 15. The boar had a 2n = 38,XY, rcp(7q-;15q+)(q24;q26) karyotype. The average of piglets per litter sired by this boar was 5.2 and the litter size was reduced by approximately 50%. The chromosomal rearrangements t(2;9;14) was inherited by four of the boar's offspring studied from two whole litters having seven piglets altogether. Meiotic chromosomes were analysed conventionally from one male translocation carrier offspring of the t(2;9;14) boar. Total sperm count and progressive motility of spermatozoa were within normal limits in one male translocation carrier offspring of the t(2;9;14) boar and in the rcp(7q-;15q+) boar. The two reciprocal translocations seem to have arisen spontaneously in these two boars. ZUSAMMENFASSUNG: Zwei Fälle reziproker Translokationen bei Ebern mit kleinen Nachkommen Würfen Von zwei Finnischen Yorkshire Ebern hatte einer drei komplexe reziproke Translokationen, wo kurze distale Chromosomensegmente zu neuen Kombinatioenen zwischen Autosomen 2, 9 und 14 fusioniert waren. Der Eber mit 2n = 38,XY,t(2;9;14)(q23;q22;q25) Karyotyp hatte Nachkommenwürfe mit etwa 3.3 Ferkel weniger und 70% Fruchtbarkeit der bei dieser Rasse normalen. In einem anderen Eber war der lange Arm von Chromosom 7 gebrochen und am Ende von Chromosom 15: 2n = 38,XY, rcp(7q-; 15q+)(q24;q26) Karyotyp. Nachkommenwurfgröße war 5.2. Das chromosomale Rearrangement t(2;9;14) wurde an 4 Nachkommen in zwei Würfen mit zusammen 7 Ferkel vererbt. Meiotische Chromosomen wurden bei einem männlichen Translokationsträger dieser Nachkommen analysiert. Gesamtspermienenzahl und ihre Vorwärtsbewegung waren in normalen Grenzen bei diesem Nahkommen ebenso wie beim rcp(7q-;15q+) Eber. Die zwei reciproken Translokationen scheinen spontan entstanden zu sein.

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Morphometric evaluations of testicular tissues from azoospermic boars in Finnish Yorkshire and Landrace breeds

Kopp

Ijäs²,

Flyckt

et al. 2008

Theriogenology

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Synaptonemal complex analysis of an X-autosome translocation-carrier in the domestic pig

Cited by 7 publications

References 5 publications

Azoospermia and Testicular Hypoplasia in a Boar Carrier of a Novel Y-Autosome Translocation

Azoospermia and Testicular Hypoplasia in a Boar Carrier of a Novel Y-Autosome Translocation

Two cases of reciprocal translocations in domestic pigs producing small litters

Morphometric evaluations of testicular tissues from azoospermic boars in Finnish Yorkshire and Landrace breeds

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