Synbiotics of Bifidobacterium breve MCC1274 and lactulose enhances production of tryptophan metabolites in fermented human fecal communities

Hashikura, Nanami; Murakami, Ryuta; Sakurai, Tomonori; Horigome, Ayako; Toda, Kazuya; Xiao, Jin‐zhong; Odamaki, Toshitaka

doi:10.1016/j.foodres.2022.112308

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…In addition, the abundance of Bacteroidetes and E. coli continued to decrease when using tested synbiotics. Similarly, the abundance of Bifidobacterium in the synbiotic group (B. breve MCC1274 and lactulose) in fermented human fecal communities showed significantly higher numbers when compared with the other treatment group [9]. In another study, synbiotics (short-chain FOS or FOS, each combined with one of four probiotics, Lactobacillus fermentum ME-3, Lactobacillus plantarum WCFS1, Lactobacillus paracasei 8700:2, or Bifidobacterium longum 46 increased bifidobacteria and the Eubacterium rectale-Clostridium coccoides group but decreased levels of E. coli [77].…”

Section: Gut Microbiota Using Feces As a Representation By Real-time Pcrmentioning

confidence: 90%

“…The combination of prebiotics and probiotics is known as synbiotics. Human fecal fermentation, an in vitro method, is commonly used to evaluate the impact of the synbiotics on the growth, diversity, and metabolic activity of gut bacteria [9]. Changes in composition and function in the gut microbiota can also be examined using advanced molecular methods such as next-generation sequencing.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Synbiotic Lacticaseibacillus paracasei, Bifidobacterium breve, and Prebiotics on the Growth Stimulation of Beneficial Gut Microbiota

Kaewarsar,

Chaiyasut,

Lailerd

et al. 2023

Foods

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The gut microbiota is a complex community of microorganisms that plays a vital role in maintaining overall health, and is comprised of Lactobacillus and Bifidobacterium. The probiotic efficacy and safety of Lacticaseibacillus paracasei and Bifidobacterium breve for consumption were confirmed by in vitro experiments. The survival rate of the probiotics showed a significant decline in in vitro gut tract simulation; however, the survival rate was more than 50%. Also, the probiotics could adhere to Caco-2 cell lines by more than 90%, inhibit the pathogenic growths, deconjugate glycocholic acid and taurodeoxycholic acid through activity of bile salt hydrolase (BSH) proteins, and lower cholesterol levels by over 46%. Regarding safety assessment, L. paracasei and B. breve showed susceptibility to some antibiotics but resistance to vancomycin and were examined as γ-hemolytic strains. Anti-inflammatory properties of B. breve with Caco-2 epithelial cell lines showed the significantly highest value (p < 0.05) for interleukin-10. Furthermore, probiotics and prebiotics (inulin, fructooligosaccharides, and galactooligosaccharides) comprise synbiotics, which have potential effects on the increased abundance of beneficial microbiota, but do not affect the growth of harmful bacteria in feces samples. Moreover, the highest concentration of short chain fatty acid was of acetic acid, followed by propionic and butyric acid.

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Section: Gut Microbiota Using Feces As a Representation By Real-time Pcrmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%