Communication systems are traditionally designed to have tight transmitter-receiver synchronization. This requirement has negligible overhead in the high-SNR regime. However, in many applications, such as wireless sensor networks, communication needs to happen primarily in the energy-efficient regime of low SNR, where requiring tight synchronization can be highly suboptimal.In this paper, we model the noisy channel with synchronization errors as a duplication/deletion/substitution channel. For this channel, we propose a new communication scheme that requires only loose transmitter-receiver synchronization. We show that the proposed scheme is asymptotically optimal for the Gaussian channel with synchronization errors in terms of energy efficiency as measured by the rate per unit energy. In the process, we also establish that the lack of synchronization causes negligible loss in energy efficiency. We further show that, for a general discrete memoryless channel with synchronization errors and a general input cost function admitting a zero-cost symbol, the rate per unit cost achieved by the proposed scheme is within a factor two of the informationtheoretic optimum.I. INTRODUCTION Traditionally, data transmission in a communication system is based on tight synchronization between the transmitter and the receiver. This tight synchronization is usually achieved through either of two strategies. In the first strategy, synchronization is achieved through periodic transmission of pilot signals, followed by transmission of information over the synchronized channel (see, e.g., [1, Chapter 6.3]). In the second strategy, data bits are differentially encoded and then modulated (e.g., differential pulse-positionmodulation) [1, Chapter 4.3.2], which implicitly achieves tight synchronization.The above strategies work well at high signal-to-noise ratios (SNRs) as the energy overhead of achieving tight synchronization is negligible compared to that of data transmission. However, in many applications, such as wireless sensor networks, space communication, or in general any communication system requiring high energy efficiency, communication by necessity has to primarily take place in the low-SNR regime (due to the concavity of the power-rate function). In such scenarios, the energy overhead to achieve tight synchronization becomes significant and can render the aforementioned strategies highly suboptimal in terms of energy efficiency. In fact, requiring tight transmitter-receiver synchronization can have arbitrarily large loss in performance in terms of energy efficiency (see Example 3 in Section III).To mitigate this, in this paper, we develop and analyze a framework to perform data transmission while only requiring loose synchronization between the transmitter and the receiver. To focus on the energyefficiency aspect, we choose the rate per unit cost (with energy being a prime example of the cost) as our performance metric. We model synchronization errors through channel duplications/deletions-an approach introduced in [2]...