Synchronization Of Autonomic Control Loops Of Blood Circulation In Patients With COVID-19

Skazkina, Viktoriia V.; Krasikova, N. S.; Borovkova, Ekaterina I.; Ishbulatov, Yurii M.; Gorshkov, A. Yu.; Korolev, A.I.; Дадаева, В.А.; Fedorovich, A.A.; Kuligin, A.V.; Драпкина, О. М.; Karavaev, Anatoly S.; Kiselev, Anton R.

doi:10.15275/rusomj.2021.0307

Cited by 9 publications

(19 citation statements)

References 24 publications

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“…After removing duplicates, 1585 results remained and were evaluated for title and abstract check. Therefore, 65 reports were considered in the full-text review stage, and 20 of those were included in the systematic review [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48], while 45 reports were excluded: 2 papers written in Russian [49,50], 5 conference papers [51][52][53][54][55], 3 comments [56][57][58], 4 case reports or case series [59][60][61][62], 2 literature reviews [63,64], 1 study protocol [65], 12 studies that did not perform a formal evaluation of autonomic functions [66][67][68][69][70][71][72][73][74][75]…”

Section: Study Selectionmentioning

confidence: 99%

“…Finally, 22 studies were included in this systematic review [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]94,95]. Details regarding the selection process are available in the PRISMA diagram (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…Reports assessed as eligible-Refs. [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. Reports added from other sources-Refs.…”

Section: Study Selectionmentioning

confidence: 99%

“…Studies included in the systematic review-Refs. [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]94,95]. Abbreviations: COVID-19, Coronavirus disease 2019.…”

Section: Study Selectionmentioning

confidence: 99%

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Autonomic Dysfunction during Acute SARS-CoV-2 Infection: A Systematic Review

Scala

Rizzo

Bellavia

et al. 2022

JCM

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Although autonomic dysfunction (AD) after the recovery from Coronavirus disease 2019 (COVID-19) has been thoroughly described, few data are available regarding the involvement of the autonomic nervous system (ANS) during the acute phase of SARS-CoV-2 infection. The primary aim of this review was to summarize current knowledge regarding the AD occurring during acute COVID-19. Secondarily, we aimed to clarify the prognostic value of ANS involvement and the role of autonomic parameters in predicting SARS-CoV-2 infection. According to the PRISMA guidelines, we performed a systematic review across Scopus and PubMed databases, resulting in 1585 records. The records check and the analysis of included reports’ references allowed us to include 22 articles. The studies were widely heterogeneous for study population, dysautonomia assessment, and COVID-19 severity. Heart rate variability was the tool most frequently chosen to analyze autonomic parameters, followed by automated pupillometry. Most studies found ANS involvement during acute COVID-19, and AD was often related to a worse outcome. Further studies are needed to clarify the role of autonomic parameters in predicting SARS-CoV-2 infection. The evidence emerging from this review suggests that a complex autonomic nervous system imbalance is a prominent feature of acute COVID-19, often leading to a poor prognosis.

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Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

“…Reports assessed as eligible-Refs. [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]. Reports added from other sources-Refs.…”

Section: Study Selectionmentioning

confidence: 99%

“…Studies included in the systematic review-Refs. [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]94,95]. Abbreviations: COVID-19, Coronavirus disease 2019.…”

Section: Study Selectionmentioning

confidence: 99%

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Autonomic Dysfunction during Acute SARS-CoV-2 Infection: A Systematic Review

Scala

Rizzo

Bellavia

et al. 2022

JCM

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“…Finally, future research should consider assessing both linear and non-linear measures of HRV and BPV, which can be a promising field for exploring autonomic cardiac loops of circulation in MG patients. Several studies have shown that such methods were useful tools for clinical practice, in particular, in patients with cardiovascular events (hypertension, myocardial infarction) [51][52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Association of Cardiac Autonomic Responses with Clinical Outcomes of Myasthenia Gravis: Short-Term Analysis of the Heart-Rate and Blood Pressure Variability

Zawadka‐Kunikowska

Rzepiński²,

Tafil-Klawe

et al. 2022

JCM

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Introduction: The aim of the study was to assess cardiac and autonomic function in patients with myasthenia gravis (MG) and to explore its relationship with disease outcomes. Methods: Thirty-eight patients with an MG were enrolled (median age 40.5 years; median disease duration 5.5 years). Cardiovascular parameters, baroreflex sensitivity (BRS), spectral indices of short-term heart rate (HRV), and systolic blood pressure variability (SBPV) were compared with age- and gender-matched controls (n = 30). Cardiac autonomic function was assessed during the response to standing (tilt) and deep breathing tests (expiration/inspiration ratio-E/I). Results: HR and BP responses to the tilt test were similar in both groups. MG patients, as compared to controls, were characterized by altered SBPV at rest, significantly reduced HR response to the deep breathing test (p < 0.001), increased sympathovagal balance after tilt (delta LF/HF-RRI, p = 0.037), and lower values of BRS (p = 0.007) and hemodynamic parameters, i.e., cardiac index, index contractility, left ventricular work index, at rest and during tilt. There was no association between disease duration and autonomic parameters. Disease severity, as determined by MGFA (Myasthenia Gravis Foundation of America) corrected for age and sex, was an independent predictor of diminished vagal tone (E/I ratio) and increased sympathetic response to tilt (delta LF/HF-RRI) as measured with HRV. Lower BRS was associated with greater disease severity and older age. Hemodynamic parameters were predominantly predicted by age and sex. Conclusion: Our results confirm cardiac autonomic dysfunction among MG patients with predominant parasympathetic impairment. Clinicians should consider evaluation of autonomic balance in MG patients with, or at risk for, cardiovascular disease.

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