Synchronization of estrus and ovulation in gilts with estradiol and prostaglandin F2α

Krealing, Robert R.; Rampacek, George B.

doi:10.1016/0093-691x(77)90227-8

Cited by 14 publications

(8 citation statements)

References 20 publications

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“…In previous reports, the progesterone levels declined to 1 ng/ml or less from 45 to 57 h following PGF2α treatment in pregnant pigs [4,5] or from 21 to 57 h in pseudopregnant pigs [5]. Estrus was observed 4 to 6 days after PGF2α administration in the pseudopregnant gilts, which is in agreement with previous reports on pregnant [4,6] and pseudopregnant [12,18,19] pigs. The present results demonstrated that exogenous PGF2α was effective in regressing the CLs of pseudopregnant gilts induced by EDP and causing synchronized estrus.…”

Section: Discussionsupporting

confidence: 81%

“…The CL of pseudopregnancy induced by these methods regresses rapidly after PGF2α administration as well as pregnancy [5]. Furthermore, the exhibited estrus [12,18,19] and fertility [12,13,18] after PGF2α treatment in pseudopregnancy are similar to those of pregnancy.The need for multiple administrations of estradiol to induce pseudopregnancy or PGF2α luteolysis has made this technique impractical for commercial application to estrus synchronization programs. Furthermore, induction of abortion and frequent administrations of drugs to control estrus are problems for animal welfare.…”

supporting

confidence: 50%

supporting

confidence: 50%

“…Pope and First [34] reported that uterine elongation appeared to result from treatment with estradiol-17β on Days 12 and 13 of the estrous cycle, which is similar to the increase seen in pregnant sows. In a previous report, the number of ovulated follicles was not affected by treatment with EB followed by PGF2α [19]. An increase in the placental weight associated with space and nutrition in the uterus results in an increase in fetal weight [35] and piglet birth weight [36].…”

Section: Discussionmentioning

confidence: 99%

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Estrus Synchronization with Pseudopregnant Gilts Induced by a Single Treatment of Estradiol Dipropionate

et al. 2010

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Abstract. The aims of this study were to determine whether a single treatment of estradiol dipropionate (EDP) could induce pseudopregnancy in gilts and to determine the effectiveness of PGF2α treatment on estrus synchronization in EDP-induced pseudopregnant gilts. In experiment 1, gilts were treated with 20 mg of EDP (n=11) or vehicle (n=5) on Day 12 (Day 0=onset of estrus). Establishment of pseudopregnancy was defined as a lack of estrus and maintenance of the plasma progesterone concentration above 1 ng/ml between Days 12 and 36. Nine of 11 gilts (82%) treated with EDP became pseudopregnant. The plasma estradiol-17β level was significantly higher in the EDP-treated gilts than in the control gilts until Day 29. In experiment 2, PGF2α was administered twice with a 24-h interval from Day 36 in pseudopregnant gilts (n=6) or Day 10 in cyclic gilts (control; n=5). Estrus after PGF2α treatment was observed in 83% of the pseudopregnant gilts. The interval from the day of the first PGF2α treatment to the onset of estrus and the peak of the LH surge was significantly shorter in the pseudopregnant gilts than in the control gilts. In experiment 3, six pseudopregnant gilts were bred by artificial insemination at the estrus after PGF2α treatment. The farrowing rate and average litter size did not differ between the PGF2α-treated pseudopregnant and cyclic gilts. These results indicate that a single treatment of EDP on Day 12 of the estrous cycle can induce pseudopregnancy in pigs and that a convenient protocol for administering PGF2α to EDP-induced pseudopregnant pigs is available for estrus synchronization programs in cyclic pigs. Key words: Estradiol dipropionate, Estrus control, Pig, Pseudopregnancy (J. Reprod. Dev. 56: [421][422][423][424][425][426][427] 2010) t is desirable to have female pigs in estrus at certain times to provide maximum use of intensive pork production facilities. Application of estrus synchronization programs enhances economic performance in the swine industry by reducing the labor required to detect estrus, facilitating the use of artificial insemination (AI) and assisting in batch farrowing. Therefore, being able to control the time of estrus in a breeding herd results in decreased reproductive efforts and costs.Artificially shortening or extending the luteal phase is important for control of the interestrous interval in cyclic animals. The corpus luteum (CL) of the cycling pig generally exhibits resistance to prostaglandin F2α (PGF2α)-induced luteolysis prior to Day 12 of the estrous cycle [1][2][3]. Consequently, multiple administrations of PGF2α in the early luteal phase are required to induce luteolysis of the functional CL and shorten the estrous cycle [2,3]. In contrast to the CL before Day 12 of the estrous cycle, the CL of the pregnant pig easily reacts to exogenous administration of PGF2α [4,5], and prompt estrus can be induced between 4 and 7 days after PGF2α treatment; however, exogenous administration of PGF2α is associated with abortion in pregnant pigs [4,6].In pigs, two phases of ...

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Section: Discussionsupporting

confidence: 81%

supporting

confidence: 50%

supporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

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Estrus Synchronization with Pseudopregnant Gilts Induced by a Single Treatment of Estradiol Dipropionate

et al. 2010

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“…Eight gilts were in the follicular phase (FOL; , six were in the luteal phase (LUT; Days 7-9), and the remaining five were ovariectomized (OVX; Day 0 = onset of estrus). In order to obtain gilts in the appropriate phase of the estrous cycle at the same time, estrus was synchronized according to the method of Kraeling and Rampacek [9], and gilts were slaughtered at the appropriate stage after the synchronized estrus. Ovariectomies were performed 25 days before the experiment started.…”

Section: Animalsmentioning

confidence: 99%

Influence of Stage of the Estrous Cycle on Insulin-Like Growth Factor-I Modulation of Luteinizing Hormone Secretion in the Gilt1

Whitley

Barb²,

Utley³

et al. 1995

Biology of Reproduction

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Follicular phase (FOL; Days 17-19; n = 8), luteal phase (LUT; Days 7-9; n = 6), and ovariectomized (OVX; n = 5) crossbred gilts were used (Day 0 = onset of estrus). Blood samples were collected via jugular vein cannula every 15 min for 2 h the day before pituitary collection. Serum was assayed for insulin-like growth factor (IGF)-I, IGF-I binding proteins (IGFBP), LH, estradiol (E2), and progesterone (P4). Anterior pituitary cells were dispersed, cultured, and challenged on Day 4 of culture (Day 0 = day of seeding) with 10(-7) M GnRH or IGF-I (10(-11), 10(-10), 10(-9), 10(-8), or 3 x 10(-8) M) individually or in combination. Serum E2 and P4 concentrations indicated that the animals were in the appropriate stage of the estrous cycle. Mean serum LH concentrations were greater (p < 0.0004) for OVX animals compared to FOL and LUT animals. Mean serum IGF-I concentrations were lower (p < 0.05) for OVX compared to FOL and LUT animals, while serum IGFBP were not different among animals. Basal LH secretion (control) was greater (p < 0.04) in OVX than in FOL or LUT cultures. Relative to control, 10(-11) M IGF-I increased (p < 0.02) LH secretion in FOL, LUT, and OVX cultures, and this response was greater (p < 0.05) in FOL and OVX than in LUT cultures. Only the 10(-11) M IGF-I enhanced basal LH secretion in LUT cultures. In addition, 10(-10) M IGF-I increased (p < 0.05) LH secretion in OVX cultures, and 10(-10) and 10(-9) M IGF-I stimulated (p < 0.05) LH secretion in FOL cultures, whereas basal LH secretion in all groups was unaffected (p > 0.05) by 10(-8) or 3 x 10(-8) M IGF-I. The GnRH-induced LH secretion was unaltered by IGF-I treatment. Results indicate that in vitro IGF-I treatment increased basal LH secretion, with reproductive status modulating LH response to IGF-I.

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Veterinary Uses of Prostaglandins

Cooper¹,

Hammond²,

Schultz³

1979

Practical Applications of Prostaglandins and Their Synthesis Inhibitors

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Synchronization of estrus and ovulation in gilts with estradiol and prostaglandin F2α

Cited by 14 publications

References 20 publications

Estrus Synchronization with Pseudopregnant Gilts Induced by a Single Treatment of Estradiol Dipropionate

Estrus Synchronization with Pseudopregnant Gilts Induced by a Single Treatment of Estradiol Dipropionate

Influence of Stage of the Estrous Cycle on Insulin-Like Growth Factor-I Modulation of Luteinizing Hormone Secretion in the Gilt1

Veterinary Uses of Prostaglandins

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