Synchronous cervical minimal deviation adenocarcinoma, gastric type adenocarcinoma and lobular endocervical glandular hyperplasia along with stil in peutz-jeghers syndrome: eliciting oncogenesis pathways

Neyaz, Azfar; Husain, Nuzhat; Deodhar, Manish; Khurana, Rohini; Shukla, Saumya; Arora, Arushi

doi:10.5146/tjpath.2017.01406

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…High-risk human papillomavirus (HR-HPV) is currently indicated to be associated in the carcinogenesis of ADC of UC 16 . There is lack of targeted therapy in CC due to poor understanding of signaling pathways underlying CC development and progression.…”

Section: Discussionmentioning

confidence: 99%

Cyclin D1 protein affecting global women’s health by regulating HPV mediated adenocarcinoma of the uterine cervix

Tripathi

Rath

Jawanjal

et al. 2019

Sci Rep

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Adenocarcinoma (ADC) of the uterine cervix (UC) is a rare form of cervical cancer (CC) caused due to the infection of Human Papilloma Virus (HPV). Cyclin D1 is one of the downstream targets of aberrantly activated Notch signaling, contribute to the etiology of CC. However, little is known about the role of Cyclin D1 in the modulation of cervical ADC and is controversial. The purpose of this study is to determine the role of Cyclin D1 protein and to elucidate the combined analysis with Notch signaling proteins in HPV associated ADCs of CC. A total of 60 biopsy samples (40 normal and 20 ADCs of CC) were analyzed for the expression of Cyclin D1 in HPV associated ADCs via immunohistochemistry and by immunoblotting. HPV-16 positive ADC patients showed a strong association with the Cyclin D1 expression (p = 0.007). The significant mean difference (p = 0.0001) and the pairwise comparison between Cyclin D1/JAG1 (p = 0.0001), and Cyclin D1/Notch-3 (p = 0.0001) were observed. The above Notch signaling proteins showed their synergistic role in modulating Cyclin D1 which in-turn regulates HPV-16 associated ADC of the uterine cervix (UC), affecting women’s global health.

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Section: Discussionmentioning

confidence: 99%

Cyclin D1 protein affecting global women’s health by regulating HPV mediated adenocarcinoma of the uterine cervix

Tripathi

Rath

Jawanjal

et al. 2019

Sci Rep

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“…A comprehensive literature search produced 1564 publications; 46 studies were identified that focused on lobular endocervical glandular hyperplasia/gastric-type adenocarcinoma in patients with Peutz-Jeghers syndrome. Thirty-eight (83%) were case reports/case series that met the inclusion criteria and were included in the analysis 13 14 16 19–53. The remaining eight studies were original research (five) or reviews (three) and were excluded from the analysis.…”

Section: Resultsmentioning

confidence: 99%

Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines

Gordhandas

Kahn

Sassine

et al. 2021

Int J Gynecol Cancer

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ObjectivesTo perform a systematic review of gastric-type adenocarcinoma of the cervix and lobular endocervical glandular hyperplasia (a possible precursor lesion) in Peutz-Jeghers syndrome, and to analyze data from the literature, along with our institutional experience, to determine recommendations for screening and detection.MethodsA comprehensive literature searc and retrospective search of pathology records at our institutio were conducted. Articles were screened by two independent reviewers. Case reports/series on lobular endocervical glandular hyperplasia/gastric-type adenocarcinoma of the cervix in Peutz-Jeghers syndrome were included. Demographic, clinical, and radiologic information was collected.ResultsA total of 1564 publications were reviewed; 38 met the inclusion criteria. Forty-nine were included in the analysis (43 from the literature, 6 from our institution). Forty-three reported on gastric-type adenocarcinoma alone, 4 on lobular endocervical glandular hyperplasia alone, and 2 on concurrent lobular endocervical glandular hyperplasia/gastric-type adenocarcinoma. Median age at diagnosis was 17 (range, 4–52) for patients with lobular endocervical glandular hyperplasia alone and 35 (range, 15–72) for those with gastric-type adenocarcinoma. The most common presenting symptoms were abdominal/pelvic pain and vaginal bleeding/discharge. Imaging was reported for 27 patients; 24 (89%) had abnormal cervical features. Papanicolaou (Pap) smear prior to diagnosis was reported for 12 patients; 6 (50%) had normal cytology, 4 (33%) atypical glandular cells, and 2 (17%) atypical cells not otherwise specified. Patients with gastric-type adenocarcinoma (n=45) were treated with surgery alone (n=16), surgery/chemotherapy/radiation (n=11), surgery/chemotherapy (n=9), surgery/radiation (n=5), or radiation/chemotherapy (n=4). Twelve (27%) of 45 patients recurred; median progression-free survival was 10 months (range, 1–148). Twenty patients (44%) died; median overall survival was 26 months (range, 2–156). Thirteen patients (27%) were alive with no evidence of disease.ConclusionsGastric-type adenocarcinoma in Peutz-Jeghers syndrome is associated with poor outcomes and short progression-free and overall survival. Screening recommendations, including pathognomonic symptom review and physical examination, with a low threshold for imaging and biopsy, may detect precursor lesions and early-stage gastric-type adenocarcinoma, leading to better outcomes in this high-risk population.PROSPERO registration numberCRD42019118151

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“… 8 Neyaz et al described the case of a Peutz–Jeghers syndrome associated with a composite synchronous cervical neoplasia comprising precursor LEGH, MDA and gastric-type adenocarcinoma (GTA) along with a serous tubal intraepithelial lesion (STIL) in the right fallopian tube. 9 …”

Section: Discussionmentioning

confidence: 99%

“…8 Neyaz et al described the case of a Peutz-Jeghers syndrome associated with a composite synchronous cervical neoplasia comprising precursor LEGH, MDA and gastric-type adenocarcinoma (GTA) along with a serous tubal intraepithelial lesion (STIL) in the right fallopian tube. 9 Peng et al reported the case of 33-year-old female patient with Peutz-Jeghers syndrome (PJS) with both cervical micro-deviation adenocarcinoma (MDA) and gastrictype adenocarcinoma (GTA). According to the analysis of immunohistochemical indexes such as MUC6, CK7, p16, ER, PgR, CEA, HIK1083 and CK20 in the two pathological areas, it proved the continuity between gastric adenocarcinoma and MDA, supporting the hypothesis that GTA originated from MDA de-differentiation.…”

Section: Dovepressmentioning

confidence: 99%

Pathology Behind Constant Watery Vaginal Discharge: A Rare Case of Uterine Cervical Minimal Deviation Adenocarcinoma

Xie¹,

Zhou²,

Chen³

et al. 2021

CMAR

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Minimal deviation adenocarcinoma (MDA) of uterine cervix is a rare malignant disease with rather poorer prognosis partially due to the early misdiagnosis. Hence, better understanding of early-stage symptoms is critical. We report a case of a 39-year-old woman came to hospital with a chief complaint of "a watery vaginal discharge for 9 months". She was further diagnosed as having uterine cervical minimal deviation adenocarcinoma in cervical LEEP specimen and MDA stage IIIC1 (FIGO 2018 staging-after correction) in post-hysterectomy histopathology. Currently, the definitive treatment is hysterectomy with adjuvant therapy based on staging. This article gives concise symptoms, history, and images of MDA colposcopy finding and histopathology, through the whole process of diagnosis and treatment for future clinical reference.

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Synchronous cervical minimal deviation adenocarcinoma, gastric type adenocarcinoma and lobular endocervical glandular hyperplasia along with stil in peutz-jeghers syndrome: eliciting oncogenesis pathways

Cited by 6 publications

References 8 publications

Cyclin D1 protein affecting global women’s health by regulating HPV mediated adenocarcinoma of the uterine cervix

Cyclin D1 protein affecting global women’s health by regulating HPV mediated adenocarcinoma of the uterine cervix

Gastric-type adenocarcinoma of the cervix in patients with Peutz-Jeghers syndrome: a systematic review of the literature with proposed screening guidelines

Pathology Behind Constant Watery Vaginal Discharge: A Rare Case of Uterine Cervical Minimal Deviation Adenocarcinoma

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